Understanding the coronary circulation through studies at the microvascular level

M. L. Marcus, W. M. Chilian, H. Kanatsuka, Kevin C Dellsperger, C. L. Eastham, K. G. Lamping

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

Studies of the coronary circulation have divided vascular resistances into three large components: large vessels, small resistance vessels, and veins. Studies of the epicardial microcirculation in the beating heart using stroboscopic illumination have suggested that resistance is more precisely controlled in different segments of the circulation. Measurements of coronary pressure in different sized arteries and arterioles have indicated that under normal conditions, 45-50% of total coronary vascular resistance resides in vessels larger than 100 μm. This distribution of vascular resistance can be altered in a nonuniform manner by a variety of physiological (autoregulation, increases in myocardial oxygen consumption, sympathetic stimulation) and pharmacological stimuli (norepinephrine, papaverine, dipyridamole, serotonin, vasopressin, nitroglycerin, adenosine, and endothelin). Studies of exchange of macromolecules in the microcirculation using fluorescent-labeled dextrans have also identified the size of the small pore (35-50 Å) in coronary microvessels that can be altered by myocardial ischemia. Studies of the coronary microcirculation have demonstrated that the control of vascular resistance is extremely complex, and mechanisms responsible for these heterogeneous responses need further examination.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalCirculation
Volume82
Issue number1
DOIs
StatePublished - Jan 1 1990

Fingerprint

Coronary Circulation
Vascular Resistance
Microcirculation
Papaverine
Dipyridamole
Endothelins
Nitroglycerin
Arterioles
Microvessels
Dextrans
Lighting
Vasopressins
Oxygen Consumption
Adenosine
Myocardial Ischemia
Veins
Serotonin
Norepinephrine
Homeostasis
Arteries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Marcus, M. L., Chilian, W. M., Kanatsuka, H., Dellsperger, K. C., Eastham, C. L., & Lamping, K. G. (1990). Understanding the coronary circulation through studies at the microvascular level. Circulation, 82(1), 1-7. https://doi.org/10.1161/01.CIR.82.1.1

Understanding the coronary circulation through studies at the microvascular level. / Marcus, M. L.; Chilian, W. M.; Kanatsuka, H.; Dellsperger, Kevin C; Eastham, C. L.; Lamping, K. G.

In: Circulation, Vol. 82, No. 1, 01.01.1990, p. 1-7.

Research output: Contribution to journalArticle

Marcus, ML, Chilian, WM, Kanatsuka, H, Dellsperger, KC, Eastham, CL & Lamping, KG 1990, 'Understanding the coronary circulation through studies at the microvascular level', Circulation, vol. 82, no. 1, pp. 1-7. https://doi.org/10.1161/01.CIR.82.1.1
Marcus ML, Chilian WM, Kanatsuka H, Dellsperger KC, Eastham CL, Lamping KG. Understanding the coronary circulation through studies at the microvascular level. Circulation. 1990 Jan 1;82(1):1-7. https://doi.org/10.1161/01.CIR.82.1.1
Marcus, M. L. ; Chilian, W. M. ; Kanatsuka, H. ; Dellsperger, Kevin C ; Eastham, C. L. ; Lamping, K. G. / Understanding the coronary circulation through studies at the microvascular level. In: Circulation. 1990 ; Vol. 82, No. 1. pp. 1-7.
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