Unraveling the role of genetics in the pathogenesis of diabetic retinopathy

Ashok Kumar Sharma, Maria L. Valle, Connor Beveridge, Yutao Liu, Shruti Sharma

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Diabetic retinopathy (DR) is a microvascular disease of the retina and the leading cause of visual disability in diabetic patients. Genetic factors have shown to play a pivotal role in DR onset, and several candidate genes have been associated with its progression. A literature search was performed to identify the genes known to be associated with DR through linkage analysis, candidate gene association, and genome-wide association studies (GWAS). A further literature search was performed to discover their potential connection with various biological pathways. A total of 65 genes were found and several of these genes belong to major signaling pathways known to play a significant role in DR, including systemic inflammation, angiogenesis, and neurogenesis. A comprehensive analysis presented in this review will be helpful in unraveling the role of genetics in the pathogenesis of DR.

Original languageEnglish (US)
Pages (from-to)534-541
Number of pages8
JournalEye (Basingstoke)
Volume33
Issue number4
DOIs
StatePublished - Apr 1 2019

Fingerprint

Diabetic Retinopathy
Genes
Genome-Wide Association Study
Neurogenesis
Genetic Association Studies
Retina
Inflammation

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Unraveling the role of genetics in the pathogenesis of diabetic retinopathy. / Sharma, Ashok Kumar; Valle, Maria L.; Beveridge, Connor; Liu, Yutao; Sharma, Shruti.

In: Eye (Basingstoke), Vol. 33, No. 4, 01.04.2019, p. 534-541.

Research output: Contribution to journalReview article

Sharma, Ashok Kumar ; Valle, Maria L. ; Beveridge, Connor ; Liu, Yutao ; Sharma, Shruti. / Unraveling the role of genetics in the pathogenesis of diabetic retinopathy. In: Eye (Basingstoke). 2019 ; Vol. 33, No. 4. pp. 534-541.
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