Up-regulation of vascular cvclooxygenase-2 in diabetes mellitus

Zsolt Bagi, Nóra Erdei, Zoltán Papp, István Édes, Akos Koller

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Diabetes mellitus is associated with disturbed regulation in the microcircuiation. A low-grade vascular inflammation has been implicated in the development of diabetes-related vascular complications, but the underlying molecular mechanisms has not yet been fully elucidated. It is known that eyelooxy genase-2 (COX-2) plays a key role in prostaglandin biosynthesis during the development of inflammation. Recent studies revealed that in diabetes increased synthesis of various prostanoids. vio up-regulation of COX-2, interleres with the regulation of vasomotor function. In this review, we will summarize the current findings regarding the role of COX-2, and COX-2-derived prostanoids in the regulation of vascular lone, as well as the possible underlying mechanisms leading to COX-2 activation in diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)52-56
Number of pages5
JournalPharmacological Reports
Volume58
Issue numberSUPPL.
StatePublished - Dec 1 2006
Externally publishedYes

Keywords

  • Arteriolar tone
  • Cyclooxygenase-2
  • Diabetes mellitus
  • Prostacyclin
  • Thromhoxane A

ASJC Scopus subject areas

  • Pharmacology

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  • Cite this

    Bagi, Z., Erdei, N., Papp, Z., Édes, I., & Koller, A. (2006). Up-regulation of vascular cvclooxygenase-2 in diabetes mellitus. Pharmacological Reports, 58(SUPPL.), 52-56.