Up-regulation of vascular cvclooxygenase-2 in diabetes mellitus

Zsolt Bagi, Nóra Erdei, Zoltán Papp, István Édes, Akos Koller

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Diabetes mellitus is associated with disturbed regulation in the microcircuiation. A low-grade vascular inflammation has been implicated in the development of diabetes-related vascular complications, but the underlying molecular mechanisms has not yet been fully elucidated. It is known that eyelooxy genase-2 (COX-2) plays a key role in prostaglandin biosynthesis during the development of inflammation. Recent studies revealed that in diabetes increased synthesis of various prostanoids. vio up-regulation of COX-2, interleres with the regulation of vasomotor function. In this review, we will summarize the current findings regarding the role of COX-2, and COX-2-derived prostanoids in the regulation of vascular lone, as well as the possible underlying mechanisms leading to COX-2 activation in diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)52-56
Number of pages5
JournalPharmacological Reports
Volume58
Issue numberSUPPL.
StatePublished - Dec 1 2006

Fingerprint

Prostaglandins
Blood Vessels
Diabetes Mellitus
Up-Regulation
Inflammation
Diabetes Complications

Keywords

  • Arteriolar tone
  • Cyclooxygenase-2
  • Diabetes mellitus
  • Prostacyclin
  • Thromhoxane A

ASJC Scopus subject areas

  • Pharmacology

Cite this

Bagi, Z., Erdei, N., Papp, Z., Édes, I., & Koller, A. (2006). Up-regulation of vascular cvclooxygenase-2 in diabetes mellitus. Pharmacological Reports, 58(SUPPL.), 52-56.

Up-regulation of vascular cvclooxygenase-2 in diabetes mellitus. / Bagi, Zsolt; Erdei, Nóra; Papp, Zoltán; Édes, István; Koller, Akos.

In: Pharmacological Reports, Vol. 58, No. SUPPL., 01.12.2006, p. 52-56.

Research output: Contribution to journalReview article

Bagi, Z, Erdei, N, Papp, Z, Édes, I & Koller, A 2006, 'Up-regulation of vascular cvclooxygenase-2 in diabetes mellitus', Pharmacological Reports, vol. 58, no. SUPPL., pp. 52-56.
Bagi Z, Erdei N, Papp Z, Édes I, Koller A. Up-regulation of vascular cvclooxygenase-2 in diabetes mellitus. Pharmacological Reports. 2006 Dec 1;58(SUPPL.):52-56.
Bagi, Zsolt ; Erdei, Nóra ; Papp, Zoltán ; Édes, István ; Koller, Akos. / Up-regulation of vascular cvclooxygenase-2 in diabetes mellitus. In: Pharmacological Reports. 2006 ; Vol. 58, No. SUPPL. pp. 52-56.
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