Update on stem cell therapy for cerebral palsy

James Edwin Carroll, Robert W. Mays

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Introduction: Due to the publicity about stem cell transplantation for the treatment of cerebral palsy, many families seek information on treatment, and many travel overseas for cell transplantation. Even so, there is little scientific confirmation of benefit, and therefore existing knowledge in the field must be summarized. Areas covered: This paper addresses the clinical protocols examining the problem, types of stem cells available for transplant, experimental models used to test the benefit of the cells, possible mechanisms of action, potential complications of cell treatment and what is needed in the field to help accelerate cell-based therapies. Expert opinion: While stem cells may be beneficial in acute injuries of the CNS the biology of stem cells is not well enough understood in chronic injuries or disorders such as cerebral palsy. More work is required at the basic level of stem cell biology, in the development of animal models, and finally in well-conceived clinical trials.

Original languageEnglish (US)
Pages (from-to)463-471
Number of pages9
JournalExpert Opinion on Biological Therapy
Volume11
Issue number4
DOIs
StatePublished - Apr 1 2011

Fingerprint

Cerebral Palsy
Cell- and Tissue-Based Therapy
Stem cells
Stem Cells
Cytology
Cell Transplantation
Wounds and Injuries
Expert Testimony
Stem Cell Transplantation
Clinical Protocols
Transplants
Action Potentials
Cell Biology
Theoretical Models
Therapeutics
Animal Models
Clinical Trials
Animals

Keywords

  • animal models
  • cerebral palsy
  • embryonic stem cells
  • induced pluripotent stem cells
  • mesenchymal cells
  • multipotent adult progenitor cells
  • stem cells
  • transplantation

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry
  • Drug Discovery

Cite this

Update on stem cell therapy for cerebral palsy. / Carroll, James Edwin; Mays, Robert W.

In: Expert Opinion on Biological Therapy, Vol. 11, No. 4, 01.04.2011, p. 463-471.

Research output: Contribution to journalReview article

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