Updates of the role of oxidative stress in the pathogenesis of ovarian cancer

Ghassan M. Saed, Michael Peter Diamond, Nicole M. Fletcher

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Clinical and epidemiological investigations have provided evidence supporting the role of reactive oxygen species (ROS) and reactive nitrogen species (RNS), collectively known as oxidative stress, in the etiology of cancer. Exogenous factors such as chronic inflammation, infection and hypoxia are major sources of cellular oxidative stress. Specifically, oxidative stress plays an important role in the pathogenesis, neoangiogenesis, and dissemination of local or distant ovarian cancer, as it is known to induce phenotypic modifications of tumor cells by cross talk between tumor cells and the surrounding stroma. Subsequently, the biological significance of the relationship between oxidative stress markers and various stages of epithelial ovarian cancer highlights potential therapeutic interventions as well as provides urgently needed early detection biomarkers. In the light of our scientific research and the most recent experimental and clinical observations, this review provides the reader with up to date most relevant findings on the role of oxidative stress in the pathogenesis of ovarian cancer and the possible therapeutic implications.

Original languageEnglish (US)
Pages (from-to)595-602
Number of pages8
JournalGynecologic Oncology
Volume145
Issue number3
DOIs
StatePublished - Jun 1 2017

Keywords

  • Chemoresistance
  • Genetic mutations
  • Hypoxia
  • Ovarian cancer
  • Oxidative stress
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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