Urinary podocyte excretion as a marker for preeclampsia

Vesna D. Garovic, Steven J. Wagner, Stephen T. Turner, David W. Rosenthal, William J. Watson, Brian C. Brost, Carl H. Rose, Larisa P Gavrilova-Jordan, Paula Craigo, Kent R. Bailey, Johannes Achenbach, Mario Schiffer, Joseph P. Grande

Research output: Contribution to journalArticle

134 Scopus citations

Abstract

Objective: The objective of this study was to examine whether podocyturia, which is the urinary excretion of viable podocytes (glomerular epithelial cells), is present in urinary sediments of patients with preeclampsia. We also aimed to compare the test characteristics of podocyturia to those angiogenic factors that have been shown to play an important role in the pathogenesis of preeclampsia (s-Flt-1, PlGF, and endoglin). Study Design: Serum angiogenic factors were measured in 44 patients with preeclampsia and 23 normotensive control patients. In a patient subset (15 cases and 16 control patients), urinary proteinuria were identified and quantified on the basis of their expressions of podocyte-specific proteins. Results: Urinary podocyte excretion occurred in all patients with preeclampsia. The positive predictive value for the diagnosis of preeclampsia was greater for podocyturia than for any of the measured angiogenic factors. Conclusion: Podocyturia is a highly sensitive and specific marker for preeclampsia. It may contribute to the development of proteinuria in preeclampsia.

Original languageEnglish (US)
Pages (from-to)320.e1-320.e7
JournalAmerican Journal of Obstetrics and Gynecology
Volume196
Issue number4
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Keywords

  • podocyte
  • podocyturia
  • preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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  • Cite this

    Garovic, V. D., Wagner, S. J., Turner, S. T., Rosenthal, D. W., Watson, W. J., Brost, B. C., Rose, C. H., Gavrilova-Jordan, L. P., Craigo, P., Bailey, K. R., Achenbach, J., Schiffer, M., & Grande, J. P. (2007). Urinary podocyte excretion as a marker for preeclampsia. American Journal of Obstetrics and Gynecology, 196(4), 320.e1-320.e7. https://doi.org/10.1016/j.ajog.2007.02.007