Urinary podocyte excretion as a marker for preeclampsia

Vesna D. Garovic, Steven J. Wagner, Stephen T. Turner, David W. Rosenthal, William J. Watson, Brian C. Brost, Carl H. Rose, Larisa P Gavrilova-Jordan, Paula Craigo, Kent R. Bailey, Johannes Achenbach, Mario Schiffer, Joseph P. Grande

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Objective: The objective of this study was to examine whether podocyturia, which is the urinary excretion of viable podocytes (glomerular epithelial cells), is present in urinary sediments of patients with preeclampsia. We also aimed to compare the test characteristics of podocyturia to those angiogenic factors that have been shown to play an important role in the pathogenesis of preeclampsia (s-Flt-1, PlGF, and endoglin). Study Design: Serum angiogenic factors were measured in 44 patients with preeclampsia and 23 normotensive control patients. In a patient subset (15 cases and 16 control patients), urinary proteinuria were identified and quantified on the basis of their expressions of podocyte-specific proteins. Results: Urinary podocyte excretion occurred in all patients with preeclampsia. The positive predictive value for the diagnosis of preeclampsia was greater for podocyturia than for any of the measured angiogenic factors. Conclusion: Podocyturia is a highly sensitive and specific marker for preeclampsia. It may contribute to the development of proteinuria in preeclampsia.

Original languageEnglish (US)
Pages (from-to)320.e1-320.e7
JournalAmerican Journal of Obstetrics and Gynecology
Volume196
Issue number4
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Fingerprint

Podocytes
Pre-Eclampsia
Angiogenesis Inducing Agents
Proteinuria
Epithelial Cells
Serum

Keywords

  • podocyte
  • podocyturia
  • preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Garovic, V. D., Wagner, S. J., Turner, S. T., Rosenthal, D. W., Watson, W. J., Brost, B. C., ... Grande, J. P. (2007). Urinary podocyte excretion as a marker for preeclampsia. American Journal of Obstetrics and Gynecology, 196(4), 320.e1-320.e7. https://doi.org/10.1016/j.ajog.2007.02.007

Urinary podocyte excretion as a marker for preeclampsia. / Garovic, Vesna D.; Wagner, Steven J.; Turner, Stephen T.; Rosenthal, David W.; Watson, William J.; Brost, Brian C.; Rose, Carl H.; Gavrilova-Jordan, Larisa P; Craigo, Paula; Bailey, Kent R.; Achenbach, Johannes; Schiffer, Mario; Grande, Joseph P.

In: American Journal of Obstetrics and Gynecology, Vol. 196, No. 4, 01.01.2007, p. 320.e1-320.e7.

Research output: Contribution to journalArticle

Garovic, VD, Wagner, SJ, Turner, ST, Rosenthal, DW, Watson, WJ, Brost, BC, Rose, CH, Gavrilova-Jordan, LP, Craigo, P, Bailey, KR, Achenbach, J, Schiffer, M & Grande, JP 2007, 'Urinary podocyte excretion as a marker for preeclampsia', American Journal of Obstetrics and Gynecology, vol. 196, no. 4, pp. 320.e1-320.e7. https://doi.org/10.1016/j.ajog.2007.02.007
Garovic VD, Wagner SJ, Turner ST, Rosenthal DW, Watson WJ, Brost BC et al. Urinary podocyte excretion as a marker for preeclampsia. American Journal of Obstetrics and Gynecology. 2007 Jan 1;196(4):320.e1-320.e7. https://doi.org/10.1016/j.ajog.2007.02.007
Garovic, Vesna D. ; Wagner, Steven J. ; Turner, Stephen T. ; Rosenthal, David W. ; Watson, William J. ; Brost, Brian C. ; Rose, Carl H. ; Gavrilova-Jordan, Larisa P ; Craigo, Paula ; Bailey, Kent R. ; Achenbach, Johannes ; Schiffer, Mario ; Grande, Joseph P. / Urinary podocyte excretion as a marker for preeclampsia. In: American Journal of Obstetrics and Gynecology. 2007 ; Vol. 196, No. 4. pp. 320.e1-320.e7.
@article{9bb92030ea6c42dfb7efc25262e69e77,
title = "Urinary podocyte excretion as a marker for preeclampsia",
abstract = "Objective: The objective of this study was to examine whether podocyturia, which is the urinary excretion of viable podocytes (glomerular epithelial cells), is present in urinary sediments of patients with preeclampsia. We also aimed to compare the test characteristics of podocyturia to those angiogenic factors that have been shown to play an important role in the pathogenesis of preeclampsia (s-Flt-1, PlGF, and endoglin). Study Design: Serum angiogenic factors were measured in 44 patients with preeclampsia and 23 normotensive control patients. In a patient subset (15 cases and 16 control patients), urinary proteinuria were identified and quantified on the basis of their expressions of podocyte-specific proteins. Results: Urinary podocyte excretion occurred in all patients with preeclampsia. The positive predictive value for the diagnosis of preeclampsia was greater for podocyturia than for any of the measured angiogenic factors. Conclusion: Podocyturia is a highly sensitive and specific marker for preeclampsia. It may contribute to the development of proteinuria in preeclampsia.",
keywords = "podocyte, podocyturia, preeclampsia",
author = "Garovic, {Vesna D.} and Wagner, {Steven J.} and Turner, {Stephen T.} and Rosenthal, {David W.} and Watson, {William J.} and Brost, {Brian C.} and Rose, {Carl H.} and Gavrilova-Jordan, {Larisa P} and Paula Craigo and Bailey, {Kent R.} and Johannes Achenbach and Mario Schiffer and Grande, {Joseph P.}",
year = "2007",
month = "1",
day = "1",
doi = "10.1016/j.ajog.2007.02.007",
language = "English (US)",
volume = "196",
pages = "320.e1--320.e7",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Urinary podocyte excretion as a marker for preeclampsia

AU - Garovic, Vesna D.

AU - Wagner, Steven J.

AU - Turner, Stephen T.

AU - Rosenthal, David W.

AU - Watson, William J.

AU - Brost, Brian C.

AU - Rose, Carl H.

AU - Gavrilova-Jordan, Larisa P

AU - Craigo, Paula

AU - Bailey, Kent R.

AU - Achenbach, Johannes

AU - Schiffer, Mario

AU - Grande, Joseph P.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Objective: The objective of this study was to examine whether podocyturia, which is the urinary excretion of viable podocytes (glomerular epithelial cells), is present in urinary sediments of patients with preeclampsia. We also aimed to compare the test characteristics of podocyturia to those angiogenic factors that have been shown to play an important role in the pathogenesis of preeclampsia (s-Flt-1, PlGF, and endoglin). Study Design: Serum angiogenic factors were measured in 44 patients with preeclampsia and 23 normotensive control patients. In a patient subset (15 cases and 16 control patients), urinary proteinuria were identified and quantified on the basis of their expressions of podocyte-specific proteins. Results: Urinary podocyte excretion occurred in all patients with preeclampsia. The positive predictive value for the diagnosis of preeclampsia was greater for podocyturia than for any of the measured angiogenic factors. Conclusion: Podocyturia is a highly sensitive and specific marker for preeclampsia. It may contribute to the development of proteinuria in preeclampsia.

AB - Objective: The objective of this study was to examine whether podocyturia, which is the urinary excretion of viable podocytes (glomerular epithelial cells), is present in urinary sediments of patients with preeclampsia. We also aimed to compare the test characteristics of podocyturia to those angiogenic factors that have been shown to play an important role in the pathogenesis of preeclampsia (s-Flt-1, PlGF, and endoglin). Study Design: Serum angiogenic factors were measured in 44 patients with preeclampsia and 23 normotensive control patients. In a patient subset (15 cases and 16 control patients), urinary proteinuria were identified and quantified on the basis of their expressions of podocyte-specific proteins. Results: Urinary podocyte excretion occurred in all patients with preeclampsia. The positive predictive value for the diagnosis of preeclampsia was greater for podocyturia than for any of the measured angiogenic factors. Conclusion: Podocyturia is a highly sensitive and specific marker for preeclampsia. It may contribute to the development of proteinuria in preeclampsia.

KW - podocyte

KW - podocyturia

KW - preeclampsia

UR - http://www.scopus.com/inward/record.url?scp=33947647864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947647864&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2007.02.007

DO - 10.1016/j.ajog.2007.02.007

M3 - Article

C2 - 17403404

AN - SCOPUS:33947647864

VL - 196

SP - 320.e1-320.e7

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 4

ER -