TY - JOUR
T1 - Use of urinary cotinine and questionnaires in the evaluation of infant exposure to tobacco smoke in epidemiologic studies
AU - Peterson, Edward L.
AU - Johnson, Christine C.
AU - Ownby, Dennis R.
N1 - Funding Information:
Supported by grant Al 24156 from the National institutes of Health and by the Fund for Henry Ford Hospital.
PY - 1997/8
Y1 - 1997/8
N2 - Exposure to environmental tobacco smoke is an important variable in many pediatric epidemiologic studies. We measured urinary cotinine, a specific metabolite of nicotine, in a population based cohort of children every other month from birth through two years of age. Extensive data regarding exposure to smokers (people in the home, in home and away from home day care, home visitors, visits to smokers) were collected monthly by way of home interviews. We evaluated, with multiple cotinine measurements as the gold standard, other measures of exposure that are more feasible to obtain in large scale studies. Comparing one cotinine to the average of multiple measurements, we found that 33.7% were in error in excess of 100 ng/mg, but 84% of the infants could be correctly classified into categories of low versus high. Parental smoking patterns had the highest predictive accuracy (fathers 67.0% and mothers 64.1%). Combining selected smoker categories (either parent, other home residents, outside day care workers) resulted in improved accuracy of 79.3%.
AB - Exposure to environmental tobacco smoke is an important variable in many pediatric epidemiologic studies. We measured urinary cotinine, a specific metabolite of nicotine, in a population based cohort of children every other month from birth through two years of age. Extensive data regarding exposure to smokers (people in the home, in home and away from home day care, home visitors, visits to smokers) were collected monthly by way of home interviews. We evaluated, with multiple cotinine measurements as the gold standard, other measures of exposure that are more feasible to obtain in large scale studies. Comparing one cotinine to the average of multiple measurements, we found that 33.7% were in error in excess of 100 ng/mg, but 84% of the infants could be correctly classified into categories of low versus high. Parental smoking patterns had the highest predictive accuracy (fathers 67.0% and mothers 64.1%). Combining selected smoker categories (either parent, other home residents, outside day care workers) resulted in improved accuracy of 79.3%.
KW - Children
KW - Cotinine
KW - Environmental tobacco smoke exposure
KW - Questionnaire
KW - Reliability
KW - Validity
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U2 - 10.1016/S0895-4356(97)00095-4
DO - 10.1016/S0895-4356(97)00095-4
M3 - Article
C2 - 9291877
AN - SCOPUS:0030852317
SN - 0895-4356
VL - 50
SP - 917
EP - 923
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
IS - 8
ER -