Using Raman spectroscopy to study the onset of labor

A pilot study

Elizabeth Vargis, C. Nathan Webb, B. C. Paria, Kelly Bennett, Jeff Reese, Ayman Al-Hendy, Anita Mahadevan-Jansen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Preterm birth is the second leading cause of neonatal mortality and leads to a myriad of complications like delayed development and cerebral palsy. Currently, there is no way to accurately predict preterm labor, making its prevention and treatment virtually impossible. While there are some at-risk patients, over half of all preterm births do not fall into any high-risk category. This study seeks to predict and prevent preterm labor by using Raman spectroscopy to detect changes in the cervix during pregnancy indicative of labor. Since Raman spectroscopy has been used to detect cancers in vivo in organs like the cervix and skin, it follows that spectra will change over the course of pregnancy. Previous studies have shown that fluorescence decreased during pregnancy and increased during post-partum exams to pre-pregnancy levels. We believe significant changes will occur in the Raman spectra obtained during the course of pregnancy. In this study, Raman spectra from the cervix of pregnant mice and women will be acquired. Specific changes that occur due to cervical softening or changes in hormonal levels will be observed to understand the likelihood that a female mouse or a woman will enter labor.

Original languageEnglish (US)
Title of host publicationAdvanced Biomedical and Clinical Diagnostic Systems IX
Volume7890
DOIs
StatePublished - May 2 2011
EventAdvanced Biomedical and Clinical Diagnostic Systems IX - San Francisco, CA, United States
Duration: Jan 23 2011Jan 25 2011

Other

OtherAdvanced Biomedical and Clinical Diagnostic Systems IX
CountryUnited States
CitySan Francisco, CA
Period1/23/111/25/11

Fingerprint

Labor Onset
Raman Spectrum Analysis
labor
pregnancy
Raman spectroscopy
Personnel
Pregnancy
Cervix Uteri
Premature Obstetric Labor
Premature Birth
Raman scattering
mice
Raman spectra
mortality
Infant Mortality
Cerebral Palsy
Skin
organs
softening
Fluorescence

Keywords

  • cervix
  • collagen
  • hormones
  • obstetrics

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Vargis, E., Webb, C. N., Paria, B. C., Bennett, K., Reese, J., Al-Hendy, A., & Mahadevan-Jansen, A. (2011). Using Raman spectroscopy to study the onset of labor: A pilot study. In Advanced Biomedical and Clinical Diagnostic Systems IX (Vol. 7890). [789019] https://doi.org/10.1117/12.881239

Using Raman spectroscopy to study the onset of labor : A pilot study. / Vargis, Elizabeth; Webb, C. Nathan; Paria, B. C.; Bennett, Kelly; Reese, Jeff; Al-Hendy, Ayman; Mahadevan-Jansen, Anita.

Advanced Biomedical and Clinical Diagnostic Systems IX. Vol. 7890 2011. 789019.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Vargis, E, Webb, CN, Paria, BC, Bennett, K, Reese, J, Al-Hendy, A & Mahadevan-Jansen, A 2011, Using Raman spectroscopy to study the onset of labor: A pilot study. in Advanced Biomedical and Clinical Diagnostic Systems IX. vol. 7890, 789019, Advanced Biomedical and Clinical Diagnostic Systems IX, San Francisco, CA, United States, 1/23/11. https://doi.org/10.1117/12.881239
Vargis E, Webb CN, Paria BC, Bennett K, Reese J, Al-Hendy A et al. Using Raman spectroscopy to study the onset of labor: A pilot study. In Advanced Biomedical and Clinical Diagnostic Systems IX. Vol. 7890. 2011. 789019 https://doi.org/10.1117/12.881239
Vargis, Elizabeth ; Webb, C. Nathan ; Paria, B. C. ; Bennett, Kelly ; Reese, Jeff ; Al-Hendy, Ayman ; Mahadevan-Jansen, Anita. / Using Raman spectroscopy to study the onset of labor : A pilot study. Advanced Biomedical and Clinical Diagnostic Systems IX. Vol. 7890 2011.
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