Vaccines make good immune theater: Immunization as described in a three-act play

Research output: Contribution to journalArticle

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Abstract

The immune response evolved to provide protection against infectious diseases. Optimal development of a protective immune response by a vaccine should mimic the steps and processes elicited during the establishment of natural immunity. Microbial infection triggers innate responses to the infection, which progresses through a series of stages consistent with the development of the action in a drama. The action is mediated by defined cellular characters whose costumes are described in CD#s with a molecular text consisting of cytokines, chemokines, antibodies, and other proteins. The main characters for initiating this drama are the dendritic cell (DC) and the T cell. Optimal activation of the DC by infection or immunization promotes the development of a more effective immune response. Newer approaches mimic or manipulate the stageplay that Mother Nature developed to promote proper DC presentation of antigen to T cells to initiate immune protection from microbial infection. This review will provide an overview of the immune response and introduce some basic and new concepts of vaccine development.

Original languageEnglish (US)
Pages (from-to)35-45
Number of pages11
JournalInfectious Diseases in Clinical Practice
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

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ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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