Vascular effects of free radicals generated by electrical stimulation.

F. S. Lamb, R. C. Webb

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Electrical field stimulation (9 V, 1.0 ms, 4 Hz) of isolated segments of rat tail arteries and dog coronary arteries inhibits contractile responses to exogenous norepinephrine and elevated potassium concentration. This inhibitory effect of electrical stimulation is blocked by various agents that alter oxygen metabolism: superoxide dismutase, catalase, glutathione, ascorbate, and dimethyl sulfoxide. The observations suggest that the inhibitory effect is due to an action of oxygen free radical metabolites that are generated by the electrical stimulation of the oxygen-rich buffer. These free radical metabolites have two actions: 1) they oxidize drugs in the experimental system, and 2) they exert a direct inhibitory action on vascular smooth muscle.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume247
Issue number5 Pt 2
StatePublished - Nov 1 1984

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Electric Stimulation
Free Radicals
Blood Vessels
Oxygen
Dimethyl Sulfoxide
Vascular Smooth Muscle
Catalase
Superoxide Dismutase
Glutathione
Tail
Reactive Oxygen Species
Coronary Vessels
Norepinephrine
Potassium
Buffers
Arteries
Dogs
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Physiology

Cite this

Vascular effects of free radicals generated by electrical stimulation. / Lamb, F. S.; Webb, R. C.

In: The American journal of physiology, Vol. 247, No. 5 Pt 2, 01.11.1984.

Research output: Contribution to journalArticle

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