Vascular effects of free radicals generated by electrical stimulation.

F. S. Lamb, R. C. Webb

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Electrical field stimulation (9 V, 1.0 ms, 4 Hz) of isolated segments of rat tail arteries and dog coronary arteries inhibits contractile responses to exogenous norepinephrine and elevated potassium concentration. This inhibitory effect of electrical stimulation is blocked by various agents that alter oxygen metabolism: superoxide dismutase, catalase, glutathione, ascorbate, and dimethyl sulfoxide. The observations suggest that the inhibitory effect is due to an action of oxygen free radical metabolites that are generated by the electrical stimulation of the oxygen-rich buffer. These free radical metabolites have two actions: 1) they oxidize drugs in the experimental system, and 2) they exert a direct inhibitory action on vascular smooth muscle.

Original languageEnglish (US)
Pages (from-to)H709-H714
JournalThe American journal of physiology
Volume247
Issue number5 Pt 2
StatePublished - Nov 1 1984

ASJC Scopus subject areas

  • Physiology

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