Vasopressin casts light on the suprachiasmatic nucleus

Takahiro Tsuji, Andrew J. Allchorne, Meng Zhang, Chiharu Tsuji, Vicky A. Tobin, Rafael Pineda, Androniki Raftogianni, Javier Eduardo Stern, Valery Grinevich, Gareth Leng, Mike Ludwig

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Key points: A subpopulation of retinal ganglion cells expresses the neuropeptide vasopressin. These retinal ganglion cells project predominately to our biological clock, the suprachiasmatic nucleus (SCN). Light-induced vasopressin release enhances the responses of SCN neurons to light. It also enhances expression of genes involved in photo-entrainment of biological rhythms. Abstract: In all animals, the transition between night and day engages a host of physiological and behavioural rhythms. These rhythms depend not on the rods and cones of the retina, but on retinal ganglion cells (RGCs) that detect the ambient light level in the environment. These project to the suprachiasmatic nucleus (SCN) of the hypothalamus to entrain circadian rhythms that are generated within the SCN. The neuropeptide vasopressin has an important role in this entrainment. Many SCN neurons express vasopressin, and it has been assumed that the role of vasopressin in the SCN reflects the activity of these cells. Here we show that vasopressin is also expressed in many retinal cells that project to the SCN. Light-evoked vasopressin release contributes to the responses of SCN neurons to light, and enhances expression of the immediate early gene c-fos in the SCN, which is involved in photic entrainment of circadian rhythms.

Original languageEnglish (US)
Pages (from-to)3497-3514
Number of pages18
JournalJournal of Physiology
Volume595
Issue number11
DOIs
StatePublished - Jun 1 2017

Fingerprint

Suprachiasmatic Nucleus
Vasopressins
Retinal Ganglion Cells
Light
Circadian Rhythm
Neuropeptides
Neurons
Biological Clocks
Retinal Cone Photoreceptor Cells
Retinal Rod Photoreceptor Cells
Vertebrate Photoreceptor Cells
Immediate-Early Genes
Periodicity
Hypothalamus
Gene Expression

Keywords

  • electrophysiology
  • microdialysis
  • retinal ganglion cells
  • suprachiasmatic nucleus
  • vasopressin

ASJC Scopus subject areas

  • Physiology

Cite this

Tsuji, T., Allchorne, A. J., Zhang, M., Tsuji, C., Tobin, V. A., Pineda, R., ... Ludwig, M. (2017). Vasopressin casts light on the suprachiasmatic nucleus. Journal of Physiology, 595(11), 3497-3514. https://doi.org/10.1113/JP274025

Vasopressin casts light on the suprachiasmatic nucleus. / Tsuji, Takahiro; Allchorne, Andrew J.; Zhang, Meng; Tsuji, Chiharu; Tobin, Vicky A.; Pineda, Rafael; Raftogianni, Androniki; Stern, Javier Eduardo; Grinevich, Valery; Leng, Gareth; Ludwig, Mike.

In: Journal of Physiology, Vol. 595, No. 11, 01.06.2017, p. 3497-3514.

Research output: Contribution to journalArticle

Tsuji, T, Allchorne, AJ, Zhang, M, Tsuji, C, Tobin, VA, Pineda, R, Raftogianni, A, Stern, JE, Grinevich, V, Leng, G & Ludwig, M 2017, 'Vasopressin casts light on the suprachiasmatic nucleus', Journal of Physiology, vol. 595, no. 11, pp. 3497-3514. https://doi.org/10.1113/JP274025
Tsuji T, Allchorne AJ, Zhang M, Tsuji C, Tobin VA, Pineda R et al. Vasopressin casts light on the suprachiasmatic nucleus. Journal of Physiology. 2017 Jun 1;595(11):3497-3514. https://doi.org/10.1113/JP274025
Tsuji, Takahiro ; Allchorne, Andrew J. ; Zhang, Meng ; Tsuji, Chiharu ; Tobin, Vicky A. ; Pineda, Rafael ; Raftogianni, Androniki ; Stern, Javier Eduardo ; Grinevich, Valery ; Leng, Gareth ; Ludwig, Mike. / Vasopressin casts light on the suprachiasmatic nucleus. In: Journal of Physiology. 2017 ; Vol. 595, No. 11. pp. 3497-3514.
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