Virus-specific delayed-type hypersensitivity (DTH). Cells mediating lymphocytic choriomeningitis virus-specific DTH reaction in mice

D. Moskophidis, L. Fang, J. Gossmann, R. Drjupin, J. Lohler, M. Bruns, F. Lehmann-Grube

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We had previously shown that the local lymphocytic choriomeningitis virus-induced delayed-type hypersensitivity (DTH) reaction in mice consists of two well delineated phases that are mediated by CD8+ and CD4+ T lymphocytes, respectively. These findings have been confirmed and extended by showing that the first CD8+ cell-dependent part of the response was enhanced by either the presence of CD4+ cells or systemic treatment with IL-2 and that it developed in the absence of detectable numbers of mononuclear phagocytes, whereas the later CD4+ cell part required monocytes or related elements. Furthermore, in the DTH reaction that was elicited with noninfectious viral Ag in mice previously immunized by infection, only the CD4+ cells participated. Thus, the two phases of the lymphocytic choriomeningitis-viral DTH reaction are principally different, which has to be taken into account when trying to assess the relevance of DTH during this virus infection.

Original languageEnglish (US)
Pages (from-to)1926-1934
Number of pages9
JournalJournal of Immunology
Volume144
Issue number5
StatePublished - Jan 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Moskophidis, D., Fang, L., Gossmann, J., Drjupin, R., Lohler, J., Bruns, M., & Lehmann-Grube, F. (1990). Virus-specific delayed-type hypersensitivity (DTH). Cells mediating lymphocytic choriomeningitis virus-specific DTH reaction in mice. Journal of Immunology, 144(5), 1926-1934.