Vitamin D for the treatment of respiratory diseases

Is it the end or just the beginning?

James Yawn, Lauren A. Lawrence, William Wise Crosby Carroll, Jennifer K. Mulligan

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

A large number of human, animal and in vitro studies have suggested that vitamin D3 (VD3) plays a critical role in inflammatory airway diseases such as asthma, chronic rhinosinusitis, and allergic rhinitis. VD3 acts upon a broad range of immune cells involved in the pathogenesis of these diseases including T-cells, dendritic cells (DCs), macrophages, and B-cells. In addition, VD3 can also regulate the functions of a number of non-immune cells including epithelial cells, fibroblasts, and smooth muscle cells. Given that VD3 has known effects on the immune system, it seems logical that supplementation with VD3 would prove efficacious in the treatment of these three diseases. While many studies, most of which are observational, have suggested that VD3 deficiency is associated with more severe disease, VD3 supplementation trials in humans have resulted in varied outcomes in terms of efficacy. In this review article we will discuss the role of VD3 in these three commonly associated respiratory diseases. We will explore the literature describing associations of VD3 deficiency with patient outcomes, cells in the respiratory microenvironment susceptible to VD3 regulation, conflicting results of VD3 supplementation trials, and potential gaps in our knowledge that may be limiting the widespread use of VD3 for the treatment of respiratory diseases such asthma, chronic rhinosinusitis and allergic rhinitis. This article is part of a Special Issue entitled '17th Vitamin D Workshop'.

Original languageEnglish (US)
Pages (from-to)326-337
Number of pages12
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume148
DOIs
StatePublished - Jan 1 2015

Fingerprint

Pulmonary diseases
Cholecalciferol
Vitamin D
Therapeutics
Avitaminosis
Asthma
Cells
T-cells
Macrophages
Immune system
Fibroblasts
Dendritic Cells
Smooth Muscle Myocytes
Muscle
Immune System
Animals
B-Lymphocytes
Epithelial Cells

Keywords

  • Asthma
  • Rhinitis
  • Sinusitis
  • Supplementation
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Vitamin D for the treatment of respiratory diseases : Is it the end or just the beginning? / Yawn, James; Lawrence, Lauren A.; Carroll, William Wise Crosby; Mulligan, Jennifer K.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 148, 01.01.2015, p. 326-337.

Research output: Contribution to journalReview article

@article{137a7b5bae044dfcad99f60dc237f6c9,
title = "Vitamin D for the treatment of respiratory diseases: Is it the end or just the beginning?",
abstract = "A large number of human, animal and in vitro studies have suggested that vitamin D3 (VD3) plays a critical role in inflammatory airway diseases such as asthma, chronic rhinosinusitis, and allergic rhinitis. VD3 acts upon a broad range of immune cells involved in the pathogenesis of these diseases including T-cells, dendritic cells (DCs), macrophages, and B-cells. In addition, VD3 can also regulate the functions of a number of non-immune cells including epithelial cells, fibroblasts, and smooth muscle cells. Given that VD3 has known effects on the immune system, it seems logical that supplementation with VD3 would prove efficacious in the treatment of these three diseases. While many studies, most of which are observational, have suggested that VD3 deficiency is associated with more severe disease, VD3 supplementation trials in humans have resulted in varied outcomes in terms of efficacy. In this review article we will discuss the role of VD3 in these three commonly associated respiratory diseases. We will explore the literature describing associations of VD3 deficiency with patient outcomes, cells in the respiratory microenvironment susceptible to VD3 regulation, conflicting results of VD3 supplementation trials, and potential gaps in our knowledge that may be limiting the widespread use of VD3 for the treatment of respiratory diseases such asthma, chronic rhinosinusitis and allergic rhinitis. This article is part of a Special Issue entitled '17th Vitamin D Workshop'.",
keywords = "Asthma, Rhinitis, Sinusitis, Supplementation, Vitamin D",
author = "James Yawn and Lawrence, {Lauren A.} and Carroll, {William Wise Crosby} and Mulligan, {Jennifer K.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/j.jsbmb.2015.01.017",
language = "English (US)",
volume = "148",
pages = "326--337",
journal = "Journal of Steroid Biochemistry and Molecular Biology",
issn = "0960-0760",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Vitamin D for the treatment of respiratory diseases

T2 - Is it the end or just the beginning?

AU - Yawn, James

AU - Lawrence, Lauren A.

AU - Carroll, William Wise Crosby

AU - Mulligan, Jennifer K.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - A large number of human, animal and in vitro studies have suggested that vitamin D3 (VD3) plays a critical role in inflammatory airway diseases such as asthma, chronic rhinosinusitis, and allergic rhinitis. VD3 acts upon a broad range of immune cells involved in the pathogenesis of these diseases including T-cells, dendritic cells (DCs), macrophages, and B-cells. In addition, VD3 can also regulate the functions of a number of non-immune cells including epithelial cells, fibroblasts, and smooth muscle cells. Given that VD3 has known effects on the immune system, it seems logical that supplementation with VD3 would prove efficacious in the treatment of these three diseases. While many studies, most of which are observational, have suggested that VD3 deficiency is associated with more severe disease, VD3 supplementation trials in humans have resulted in varied outcomes in terms of efficacy. In this review article we will discuss the role of VD3 in these three commonly associated respiratory diseases. We will explore the literature describing associations of VD3 deficiency with patient outcomes, cells in the respiratory microenvironment susceptible to VD3 regulation, conflicting results of VD3 supplementation trials, and potential gaps in our knowledge that may be limiting the widespread use of VD3 for the treatment of respiratory diseases such asthma, chronic rhinosinusitis and allergic rhinitis. This article is part of a Special Issue entitled '17th Vitamin D Workshop'.

AB - A large number of human, animal and in vitro studies have suggested that vitamin D3 (VD3) plays a critical role in inflammatory airway diseases such as asthma, chronic rhinosinusitis, and allergic rhinitis. VD3 acts upon a broad range of immune cells involved in the pathogenesis of these diseases including T-cells, dendritic cells (DCs), macrophages, and B-cells. In addition, VD3 can also regulate the functions of a number of non-immune cells including epithelial cells, fibroblasts, and smooth muscle cells. Given that VD3 has known effects on the immune system, it seems logical that supplementation with VD3 would prove efficacious in the treatment of these three diseases. While many studies, most of which are observational, have suggested that VD3 deficiency is associated with more severe disease, VD3 supplementation trials in humans have resulted in varied outcomes in terms of efficacy. In this review article we will discuss the role of VD3 in these three commonly associated respiratory diseases. We will explore the literature describing associations of VD3 deficiency with patient outcomes, cells in the respiratory microenvironment susceptible to VD3 regulation, conflicting results of VD3 supplementation trials, and potential gaps in our knowledge that may be limiting the widespread use of VD3 for the treatment of respiratory diseases such asthma, chronic rhinosinusitis and allergic rhinitis. This article is part of a Special Issue entitled '17th Vitamin D Workshop'.

KW - Asthma

KW - Rhinitis

KW - Sinusitis

KW - Supplementation

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=84925488491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925488491&partnerID=8YFLogxK

U2 - 10.1016/j.jsbmb.2015.01.017

DO - 10.1016/j.jsbmb.2015.01.017

M3 - Review article

VL - 148

SP - 326

EP - 337

JO - Journal of Steroid Biochemistry and Molecular Biology

JF - Journal of Steroid Biochemistry and Molecular Biology

SN - 0960-0760

ER -