Vitamins and nutrients as primary treatments in experimental brain injury: Clinical implications for nutraceutical therapies

Cole Vonder Haar, Todd C. Peterson, Kris M. Martens, Michael R. Hoane

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

With the numerous failures of pharmaceuticals to treat traumatic brain injury in humans, more researchers have become interested in combination therapies. This is largely due to the multimodal nature of damage from injury, which causes excitotoxicity, oxidative stress, edema, neuroinflammation and cell death. Polydrug treatments have the potential to target multiple aspects of the secondary injury cascade, while many previous therapies focused on one particular aspect. Of specific note are vitamins, minerals and nutrients that can be utilized to supplement other therapies. Many of these have low toxicity, are already FDA approved and have minimal interactions with other drugs, making them attractive targets for therapeutics. Over the past 20 years, interest in supplementation and supraphysiologic dosing of nutrients for brain injury has increased and indeed many vitamins and nutrients now have a considerable body of the literature backing their use. Here, we review several of the prominent therapies in the category of nutraceutical treatment for brain injury in experimental models, including vitamins (B2, B3, B6, B9, C, D, E), herbs and traditional medicines (ginseng, Gingko biloba), flavonoids, and other nutrients (magnesium, zinc, carnitine, omega-3 fatty acids). While there is still much work to be done, several of these have strong potential for clinical therapies, particularly with regard to polydrug regimens. This article is part of a Special Issue entitled SI:Brain injury and recovery.

Original languageEnglish (US)
Pages (from-to)114-129
Number of pages16
JournalBrain Research
Volume1640
DOIs
StatePublished - Jan 1 2016

Fingerprint

Dietary Supplements
Vitamins
Brain Injuries
Food
Therapeutics
Ginkgo biloba
Panax
Niacinamide
Riboflavin
Carnitine
Omega-3 Fatty Acids
Wounds and Injuries
Traditional Medicine
Flavonoids
Pharmaceutical Preparations
Magnesium
Minerals
Zinc
Edema
Oxidative Stress

Keywords

  • Minerals
  • Nutrients
  • Polytherapy
  • TBI
  • Vitamins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Vitamins and nutrients as primary treatments in experimental brain injury : Clinical implications for nutraceutical therapies. / Vonder Haar, Cole; Peterson, Todd C.; Martens, Kris M.; Hoane, Michael R.

In: Brain Research, Vol. 1640, 01.01.2016, p. 114-129.

Research output: Contribution to journalReview article

@article{39819d1a3cb3488889768e9ee43dd743,
title = "Vitamins and nutrients as primary treatments in experimental brain injury: Clinical implications for nutraceutical therapies",
abstract = "With the numerous failures of pharmaceuticals to treat traumatic brain injury in humans, more researchers have become interested in combination therapies. This is largely due to the multimodal nature of damage from injury, which causes excitotoxicity, oxidative stress, edema, neuroinflammation and cell death. Polydrug treatments have the potential to target multiple aspects of the secondary injury cascade, while many previous therapies focused on one particular aspect. Of specific note are vitamins, minerals and nutrients that can be utilized to supplement other therapies. Many of these have low toxicity, are already FDA approved and have minimal interactions with other drugs, making them attractive targets for therapeutics. Over the past 20 years, interest in supplementation and supraphysiologic dosing of nutrients for brain injury has increased and indeed many vitamins and nutrients now have a considerable body of the literature backing their use. Here, we review several of the prominent therapies in the category of nutraceutical treatment for brain injury in experimental models, including vitamins (B2, B3, B6, B9, C, D, E), herbs and traditional medicines (ginseng, Gingko biloba), flavonoids, and other nutrients (magnesium, zinc, carnitine, omega-3 fatty acids). While there is still much work to be done, several of these have strong potential for clinical therapies, particularly with regard to polydrug regimens. This article is part of a Special Issue entitled SI:Brain injury and recovery.",
keywords = "Minerals, Nutrients, Polytherapy, TBI, Vitamins",
author = "{Vonder Haar}, Cole and Peterson, {Todd C.} and Martens, {Kris M.} and Hoane, {Michael R.}",
year = "2016",
month = "1",
day = "1",
doi = "10.1016/j.brainres.2015.12.030",
language = "English (US)",
volume = "1640",
pages = "114--129",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",

}

TY - JOUR

T1 - Vitamins and nutrients as primary treatments in experimental brain injury

T2 - Clinical implications for nutraceutical therapies

AU - Vonder Haar, Cole

AU - Peterson, Todd C.

AU - Martens, Kris M.

AU - Hoane, Michael R.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - With the numerous failures of pharmaceuticals to treat traumatic brain injury in humans, more researchers have become interested in combination therapies. This is largely due to the multimodal nature of damage from injury, which causes excitotoxicity, oxidative stress, edema, neuroinflammation and cell death. Polydrug treatments have the potential to target multiple aspects of the secondary injury cascade, while many previous therapies focused on one particular aspect. Of specific note are vitamins, minerals and nutrients that can be utilized to supplement other therapies. Many of these have low toxicity, are already FDA approved and have minimal interactions with other drugs, making them attractive targets for therapeutics. Over the past 20 years, interest in supplementation and supraphysiologic dosing of nutrients for brain injury has increased and indeed many vitamins and nutrients now have a considerable body of the literature backing their use. Here, we review several of the prominent therapies in the category of nutraceutical treatment for brain injury in experimental models, including vitamins (B2, B3, B6, B9, C, D, E), herbs and traditional medicines (ginseng, Gingko biloba), flavonoids, and other nutrients (magnesium, zinc, carnitine, omega-3 fatty acids). While there is still much work to be done, several of these have strong potential for clinical therapies, particularly with regard to polydrug regimens. This article is part of a Special Issue entitled SI:Brain injury and recovery.

AB - With the numerous failures of pharmaceuticals to treat traumatic brain injury in humans, more researchers have become interested in combination therapies. This is largely due to the multimodal nature of damage from injury, which causes excitotoxicity, oxidative stress, edema, neuroinflammation and cell death. Polydrug treatments have the potential to target multiple aspects of the secondary injury cascade, while many previous therapies focused on one particular aspect. Of specific note are vitamins, minerals and nutrients that can be utilized to supplement other therapies. Many of these have low toxicity, are already FDA approved and have minimal interactions with other drugs, making them attractive targets for therapeutics. Over the past 20 years, interest in supplementation and supraphysiologic dosing of nutrients for brain injury has increased and indeed many vitamins and nutrients now have a considerable body of the literature backing their use. Here, we review several of the prominent therapies in the category of nutraceutical treatment for brain injury in experimental models, including vitamins (B2, B3, B6, B9, C, D, E), herbs and traditional medicines (ginseng, Gingko biloba), flavonoids, and other nutrients (magnesium, zinc, carnitine, omega-3 fatty acids). While there is still much work to be done, several of these have strong potential for clinical therapies, particularly with regard to polydrug regimens. This article is part of a Special Issue entitled SI:Brain injury and recovery.

KW - Minerals

KW - Nutrients

KW - Polytherapy

KW - TBI

KW - Vitamins

UR - http://www.scopus.com/inward/record.url?scp=84953455558&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84953455558&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2015.12.030

DO - 10.1016/j.brainres.2015.12.030

M3 - Review article

C2 - 26723564

AN - SCOPUS:84953455558

VL - 1640

SP - 114

EP - 129

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -