Voriconazole: A second-generation triazole

P. H. Chandrasekar, E. Manavathu

Research output: Contribution to journalReview article

97 Scopus citations

Abstract

Voriconazole, a derivative of fluconazole, is an antifungal triazole with expanded spectrum of activity against a variety of yeasts and filamentous fungi. It exhibits fungicidal activity against Aspergillus species. Preliminary data from animal models and clinical trials show promise in the treatment of candidiasis and aspergillosis. Of concern is the development of resistance to voriconazole and cross-resistance with other azoles. Voriconazole is a welcome addition to our limited armamentarium against potentially fatal fungal infections.

Original languageEnglish (US)
Pages (from-to)135-148
Number of pages14
JournalDrugs of Today
Volume37
Issue number2
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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