Weight loss in rats exposed to repeated acute restraint stress is independent of energy or leptin status

Ruth Babette Harris, Tiffany D. Mitchell, Jacob Simpson, Stephen M. Redmann, Bradley D. Youngblood, Donna H. Ryan

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Acute release of corticotropin-releasing factor (CRF) during repeated restraint (3-h restraint on each of 3 days) causes temporary hypophagia but chronic suppression of body weight in rats. Here we demonstrated that a second bout of repeated restraint caused additional weight loss, but continuing restraint daily for 10 days did not increase weight loss because the rats adapted to the stress. In these two studies serum leptin, which suppresses the endocrine response to stress, was reduced in restrained rats. Peripheral infusion of leptin before and during restraint did not prevent stress-induced weight loss, although stress-induced corticosterone release was suppressed. Restrained rats were hyperthermic during restraint, but there was no evidence that fever or elevated free interleukin-6 caused the sustained reduction in weight. Restraining food-restricted rats caused a small but significant weight loss. Food-restricted rats fed ad libitum after the end of restraint showed a blunted hyperphagia and slower rate of weight regain than their controls. These results indicate that repeated acute stress induces a chronic change in weight independent of stress-induced hypophagia and may represent a change in homeostasis initiated by repeated acute activation of the central CRF system.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume282
Issue number1 51-1
StatePublished - Jul 2 2002
Externally publishedYes

Fingerprint

Leptin
Weight Loss
Corticotropin-Releasing Hormone
Weights and Measures
Food
Hyperphagia
Corticosterone
Interleukin-6
Homeostasis
Fever
Body Weight
Serum

Keywords

  • Corticosterone
  • Corticotropin-releasing factor
  • Food intake
  • Food restriction

ASJC Scopus subject areas

  • Physiology

Cite this

Weight loss in rats exposed to repeated acute restraint stress is independent of energy or leptin status. / Harris, Ruth Babette; Mitchell, Tiffany D.; Simpson, Jacob; Redmann, Stephen M.; Youngblood, Bradley D.; Ryan, Donna H.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 282, No. 1 51-1, 02.07.2002.

Research output: Contribution to journalArticle

Harris, Ruth Babette ; Mitchell, Tiffany D. ; Simpson, Jacob ; Redmann, Stephen M. ; Youngblood, Bradley D. ; Ryan, Donna H. / Weight loss in rats exposed to repeated acute restraint stress is independent of energy or leptin status. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2002 ; Vol. 282, No. 1 51-1.
@article{cbed61883d60446092654eec12440472,
title = "Weight loss in rats exposed to repeated acute restraint stress is independent of energy or leptin status",
abstract = "Acute release of corticotropin-releasing factor (CRF) during repeated restraint (3-h restraint on each of 3 days) causes temporary hypophagia but chronic suppression of body weight in rats. Here we demonstrated that a second bout of repeated restraint caused additional weight loss, but continuing restraint daily for 10 days did not increase weight loss because the rats adapted to the stress. In these two studies serum leptin, which suppresses the endocrine response to stress, was reduced in restrained rats. Peripheral infusion of leptin before and during restraint did not prevent stress-induced weight loss, although stress-induced corticosterone release was suppressed. Restrained rats were hyperthermic during restraint, but there was no evidence that fever or elevated free interleukin-6 caused the sustained reduction in weight. Restraining food-restricted rats caused a small but significant weight loss. Food-restricted rats fed ad libitum after the end of restraint showed a blunted hyperphagia and slower rate of weight regain than their controls. These results indicate that repeated acute stress induces a chronic change in weight independent of stress-induced hypophagia and may represent a change in homeostasis initiated by repeated acute activation of the central CRF system.",
keywords = "Corticosterone, Corticotropin-releasing factor, Food intake, Food restriction",
author = "Harris, {Ruth Babette} and Mitchell, {Tiffany D.} and Jacob Simpson and Redmann, {Stephen M.} and Youngblood, {Bradley D.} and Ryan, {Donna H.}",
year = "2002",
month = "7",
day = "2",
language = "English (US)",
volume = "282",
journal = "American Journal of Physiology - Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "1 51-1",

}

TY - JOUR

T1 - Weight loss in rats exposed to repeated acute restraint stress is independent of energy or leptin status

AU - Harris, Ruth Babette

AU - Mitchell, Tiffany D.

AU - Simpson, Jacob

AU - Redmann, Stephen M.

AU - Youngblood, Bradley D.

AU - Ryan, Donna H.

PY - 2002/7/2

Y1 - 2002/7/2

N2 - Acute release of corticotropin-releasing factor (CRF) during repeated restraint (3-h restraint on each of 3 days) causes temporary hypophagia but chronic suppression of body weight in rats. Here we demonstrated that a second bout of repeated restraint caused additional weight loss, but continuing restraint daily for 10 days did not increase weight loss because the rats adapted to the stress. In these two studies serum leptin, which suppresses the endocrine response to stress, was reduced in restrained rats. Peripheral infusion of leptin before and during restraint did not prevent stress-induced weight loss, although stress-induced corticosterone release was suppressed. Restrained rats were hyperthermic during restraint, but there was no evidence that fever or elevated free interleukin-6 caused the sustained reduction in weight. Restraining food-restricted rats caused a small but significant weight loss. Food-restricted rats fed ad libitum after the end of restraint showed a blunted hyperphagia and slower rate of weight regain than their controls. These results indicate that repeated acute stress induces a chronic change in weight independent of stress-induced hypophagia and may represent a change in homeostasis initiated by repeated acute activation of the central CRF system.

AB - Acute release of corticotropin-releasing factor (CRF) during repeated restraint (3-h restraint on each of 3 days) causes temporary hypophagia but chronic suppression of body weight in rats. Here we demonstrated that a second bout of repeated restraint caused additional weight loss, but continuing restraint daily for 10 days did not increase weight loss because the rats adapted to the stress. In these two studies serum leptin, which suppresses the endocrine response to stress, was reduced in restrained rats. Peripheral infusion of leptin before and during restraint did not prevent stress-induced weight loss, although stress-induced corticosterone release was suppressed. Restrained rats were hyperthermic during restraint, but there was no evidence that fever or elevated free interleukin-6 caused the sustained reduction in weight. Restraining food-restricted rats caused a small but significant weight loss. Food-restricted rats fed ad libitum after the end of restraint showed a blunted hyperphagia and slower rate of weight regain than their controls. These results indicate that repeated acute stress induces a chronic change in weight independent of stress-induced hypophagia and may represent a change in homeostasis initiated by repeated acute activation of the central CRF system.

KW - Corticosterone

KW - Corticotropin-releasing factor

KW - Food intake

KW - Food restriction

UR - http://www.scopus.com/inward/record.url?scp=0036083642&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036083642&partnerID=8YFLogxK

M3 - Article

VL - 282

JO - American Journal of Physiology - Heart and Circulatory Physiology

JF - American Journal of Physiology - Heart and Circulatory Physiology

SN - 0363-6135

IS - 1 51-1

ER -