Why did coapt win while mitra-FR failed? Defining the appropriate patient population for MitraClip

Kimberly Atianzar; Ming Zhang; Zachary Newhart; Sameer Gafoor

doi:10.15420/icr.2018.40.1

Why did coapt win while mitra-FR failed? Defining the appropriate patient population for MitraClip

Kimberly Atianzar, Ming Zhang, Zachary Newhart, Sameer Gafoor

Cardiology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

In 2018, the world of functional mitral regurgitation changed with the presentation of two trials - Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation (MITRA-FR) and Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation (COAPT). The trials, which seemed to point in two different directions, raised significant questions for the field. This article looks at the differences in effective regurgitant area, guideline-directed medical therapy, patient selection, technical clues and other reasons why the trials had similar aims but very different findings.

Original language	English (US)
Pages (from-to)	45-47
Number of pages	3
Journal	Interventional Cardiology Review
Volume	14
Issue number	1
DOIs	https://doi.org/10.15420/icr.2018.40.1
State	Published - 2019

Keywords

COAPT
Congestive heart failure
Effective orifice area
Functional mitral regurgitation
Heart failure
MITRA-FR
Mitral regurgitation
Optimal medical therapy
Secondary mitral regurgitation

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.15420/icr.2018.40.1

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abstract = "In 2018, the world of functional mitral regurgitation changed with the presentation of two trials - Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation (MITRA-FR) and Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation (COAPT). The trials, which seemed to point in two different directions, raised significant questions for the field. This article looks at the differences in effective regurgitant area, guideline-directed medical therapy, patient selection, technical clues and other reasons why the trials had similar aims but very different findings.",

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