Abstract
The traditional anion gap [AG = Na - Cl - (total CO2)] mean value of 12 mean value of 12 mEq/L was established during the 1970s with analyzer methods that are no longer used widely: No studies have systematically compared mean AG values from analyzers in current use. We used data from the healthy subjects obtained from 27 clinical laboratories, 5 manufacturers, and 8 publications to compute mean AG values from 1970s analyzers and 8 current analyzers. We also compared mean AG values by evaluating Na, Cl, and total CO2 data from the College of American Pathologists Chemistry Surveys (1990- 1996). Data from healthy subjects showed that overall mean AG values of the 9 analyzers ranged from 5.9 to 12.4 mEq/L. The pooled (ie, average) AG SD was 2.3 mEq/L. We then used the data of the Surveys and the mean value from 1 analyzer to compute predicted mean values for the other 7 current analyzers. Almost all mean AG values predicted from the Surveys agreed (within 1.5 mEq/L) with mean values from healthy subjects. These results show that mean values of analyzers vary widely, indicating that analytic bias strongly influences the AG. The results should be a useful guide for the AG measurements that can be expected from different analyzers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 735-742 |
| Number of pages | 8 |
| Journal | American Journal of Clinical Pathology |
| Volume | 110 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1998 |
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Keywords
- Acid-base imbalance
- Anion gap
- Clinical chemistry
- Electrolyses
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Wide variation in serum anion gap measurements by chemistry analyzers. / Paulson, William D.; Roberts, William L.; Lurie, Aubrey A.; Koch, David D.; Butch, Anthony W.; Aguanno, James J.
In: American Journal of Clinical Pathology, Vol. 110, No. 6, 01.01.1998, p. 735-742.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Wide variation in serum anion gap measurements by chemistry analyzers
AU - Paulson, William D.
AU - Roberts, William L.
AU - Lurie, Aubrey A.
AU - Koch, David D.
AU - Butch, Anthony W.
AU - Aguanno, James J.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - The traditional anion gap [AG = Na - Cl - (total CO2)] mean value of 12 mean value of 12 mEq/L was established during the 1970s with analyzer methods that are no longer used widely: No studies have systematically compared mean AG values from analyzers in current use. We used data from the healthy subjects obtained from 27 clinical laboratories, 5 manufacturers, and 8 publications to compute mean AG values from 1970s analyzers and 8 current analyzers. We also compared mean AG values by evaluating Na, Cl, and total CO2 data from the College of American Pathologists Chemistry Surveys (1990- 1996). Data from healthy subjects showed that overall mean AG values of the 9 analyzers ranged from 5.9 to 12.4 mEq/L. The pooled (ie, average) AG SD was 2.3 mEq/L. We then used the data of the Surveys and the mean value from 1 analyzer to compute predicted mean values for the other 7 current analyzers. Almost all mean AG values predicted from the Surveys agreed (within 1.5 mEq/L) with mean values from healthy subjects. These results show that mean values of analyzers vary widely, indicating that analytic bias strongly influences the AG. The results should be a useful guide for the AG measurements that can be expected from different analyzers.
AB - The traditional anion gap [AG = Na - Cl - (total CO2)] mean value of 12 mean value of 12 mEq/L was established during the 1970s with analyzer methods that are no longer used widely: No studies have systematically compared mean AG values from analyzers in current use. We used data from the healthy subjects obtained from 27 clinical laboratories, 5 manufacturers, and 8 publications to compute mean AG values from 1970s analyzers and 8 current analyzers. We also compared mean AG values by evaluating Na, Cl, and total CO2 data from the College of American Pathologists Chemistry Surveys (1990- 1996). Data from healthy subjects showed that overall mean AG values of the 9 analyzers ranged from 5.9 to 12.4 mEq/L. The pooled (ie, average) AG SD was 2.3 mEq/L. We then used the data of the Surveys and the mean value from 1 analyzer to compute predicted mean values for the other 7 current analyzers. Almost all mean AG values predicted from the Surveys agreed (within 1.5 mEq/L) with mean values from healthy subjects. These results show that mean values of analyzers vary widely, indicating that analytic bias strongly influences the AG. The results should be a useful guide for the AG measurements that can be expected from different analyzers.
KW - Acid-base imbalance
KW - Anion gap
KW - Clinical chemistry
KW - Electrolyses
UR - http://www.scopus.com/inward/record.url?scp=0031795014&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031795014&partnerID=8YFLogxK
U2 - 10.1093/ajcp/110.6.735
DO - 10.1093/ajcp/110.6.735
M3 - Article
VL - 110
SP - 735
EP - 742
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 6
ER -