Will thallium-201 replace gallium-67 in salivary gland scintigraphy?

Ali Syed Arbab, Kiyoshi Koizumi, Sachiko Hiraike, Keiji Toyama, Takao Arai, Tsutomu Araki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We investigated and compared findings on combined 99m TC pertechnetate- 201 Tl with those of [ 99m Tc]pertechnetate- 67 Ga scintiscans to elucidate the advantages of 201 Tl in detecting various salivary glands disorders. Methods: We studied 23 patients: 6 had sialadenitis, 12 had benign tumors and 5 had malignant tumors. All but four patients had undergone [ 99m Tc]pertechnetate (before and after lemon stimulation), 201 Tl (early and delayed) and 67 Ga imaging. Results: Five of six sialadenitis patients showed various degrees of diffuse uptake of 99m Tc. All six except one showed early uptake without retention of 201 Tl on delayed imaging. The 67 Ga scan showed uptake in all patients except one. Nine of 12 benign tumors showed a cold defect on 99m Tc scans. Patients with Warthin's tumors and plasmacytoma showed increased 99m Tc uptake at the tumor with retention. The 201 Tl scan showed early uptake without retention in benign tumors except in three patients, two of whom had Warthin's tumor. Five of the benign tumors, however, were positive on 67 Ga scan. None of the malignant tumors showed any uptake of 99m Tc. The 201 Tl scan showed uptake with tumor retention on delayed images in three patients; three other patients also had positive 67 Ga scans. Overall, sensitivity and specificity of 201 Tl in detecting malignant tumors were 60% and 73%, respectively, with a negative predictive value of 85%. Sensitivity and specificity for 67 Ga were 60% and 47%, respectively, with a negative predictive value of 80%. Conclusion: In view of sensitivity, specificity and convenience of 201 Tl as well as future prospects for dual- isotope acquisition, 67 Ga may be replaced by 201 Tl in detecting salivary gland disorder.

Original languageEnglish (US)
Pages (from-to)1819-1823
Number of pages5
JournalJournal of Nuclear Medicine
Volume37
Issue number11
StatePublished - Nov 1 1996
Externally publishedYes

Fingerprint

Gallium
Thallium
Salivary Glands
Radionuclide Imaging
Sodium Pertechnetate Tc 99m
Neoplasms
Adenolymphoma
Sialadenitis
Sensitivity and Specificity
Plasmacytoma
Isotopes

Keywords

  • gallium-67
  • salivary glands
  • technetium-99m
  • thallium-201

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Arbab, A. S., Koizumi, K., Hiraike, S., Toyama, K., Arai, T., & Araki, T. (1996). Will thallium-201 replace gallium-67 in salivary gland scintigraphy? Journal of Nuclear Medicine, 37(11), 1819-1823.

Will thallium-201 replace gallium-67 in salivary gland scintigraphy? / Arbab, Ali Syed; Koizumi, Kiyoshi; Hiraike, Sachiko; Toyama, Keiji; Arai, Takao; Araki, Tsutomu.

In: Journal of Nuclear Medicine, Vol. 37, No. 11, 01.11.1996, p. 1819-1823.

Research output: Contribution to journalArticle

Arbab, AS, Koizumi, K, Hiraike, S, Toyama, K, Arai, T & Araki, T 1996, 'Will thallium-201 replace gallium-67 in salivary gland scintigraphy?', Journal of Nuclear Medicine, vol. 37, no. 11, pp. 1819-1823.
Arbab AS, Koizumi K, Hiraike S, Toyama K, Arai T, Araki T. Will thallium-201 replace gallium-67 in salivary gland scintigraphy? Journal of Nuclear Medicine. 1996 Nov 1;37(11):1819-1823.
Arbab, Ali Syed ; Koizumi, Kiyoshi ; Hiraike, Sachiko ; Toyama, Keiji ; Arai, Takao ; Araki, Tsutomu. / Will thallium-201 replace gallium-67 in salivary gland scintigraphy?. In: Journal of Nuclear Medicine. 1996 ; Vol. 37, No. 11. pp. 1819-1823.
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abstract = "We investigated and compared findings on combined 99m TC pertechnetate- 201 Tl with those of [ 99m Tc]pertechnetate- 67 Ga scintiscans to elucidate the advantages of 201 Tl in detecting various salivary glands disorders. Methods: We studied 23 patients: 6 had sialadenitis, 12 had benign tumors and 5 had malignant tumors. All but four patients had undergone [ 99m Tc]pertechnetate (before and after lemon stimulation), 201 Tl (early and delayed) and 67 Ga imaging. Results: Five of six sialadenitis patients showed various degrees of diffuse uptake of 99m Tc. All six except one showed early uptake without retention of 201 Tl on delayed imaging. The 67 Ga scan showed uptake in all patients except one. Nine of 12 benign tumors showed a cold defect on 99m Tc scans. Patients with Warthin's tumors and plasmacytoma showed increased 99m Tc uptake at the tumor with retention. The 201 Tl scan showed early uptake without retention in benign tumors except in three patients, two of whom had Warthin's tumor. Five of the benign tumors, however, were positive on 67 Ga scan. None of the malignant tumors showed any uptake of 99m Tc. The 201 Tl scan showed uptake with tumor retention on delayed images in three patients; three other patients also had positive 67 Ga scans. Overall, sensitivity and specificity of 201 Tl in detecting malignant tumors were 60{\%} and 73{\%}, respectively, with a negative predictive value of 85{\%}. Sensitivity and specificity for 67 Ga were 60{\%} and 47{\%}, respectively, with a negative predictive value of 80{\%}. Conclusion: In view of sensitivity, specificity and convenience of 201 Tl as well as future prospects for dual- isotope acquisition, 67 Ga may be replaced by 201 Tl in detecting salivary gland disorder.",
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