Withdrawal of antiepileptic medications following epilepsy surgery

Anthony M Murro, Don W. King, Joseph R. Smith, Brian B. Gallagher, Herman F. Flanigin, David W. Loring, Gregory P Lee, Rebecca Campbell, Kimford Meador, Patricia H. Revolinski

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13 Scopus citations


We followed 104 patients to determine the prognosis for antiepileptic medication withdrawal following anterior temporal lobectomy for complex partial seizures. Thirty-nine of the 104 patients underwent a trial of complete medication withdrawal following a minimum 1-year seizure-free postoperative period. The likelihood of remaining seizure-free in these 39 patients was 77% at 1 year, 72% at 2 years, and 66% at 3 years. A prolonged duration of epilepsy prior to surgery significantly increased the risk for recurrent seizures. These findings suggest that patients who remain seizure-free following surgery for temporal lobe complex partial seizures have a good prognosis for remaining seizure-free following anti-epileptic medication withdrawal.

Original languageEnglish (US)
Pages (from-to)39-42
Number of pages4
JournalJournal of Epilepsy
Issue number1
StatePublished - Jan 1 1991


  • Anticonvulsants
  • Complex partial seizures
  • Epilepsy
  • Epilepsy surgery
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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    Murro, A. M., King, D. W., Smith, J. R., Gallagher, B. B., Flanigin, H. F., Loring, D. W., Lee, G. P., Campbell, R., Meador, K., & Revolinski, P. H. (1991). Withdrawal of antiepileptic medications following epilepsy surgery. Journal of Epilepsy, 4(1), 39-42. https://doi.org/10.1016/0896-6974(91)90121-X