Withdrawal of antiepileptic medications following epilepsy surgery

Anthony M Murro, Don W. King, Joseph R. Smith, Brian B. Gallagher, Herman F. Flanigin, David W. Loring, Gregory P Lee, Rebecca Campbell, Kimford Meador, Patricia H. Revolinski

Research output: Contribution to journalArticle

13 Scopus citations


We followed 104 patients to determine the prognosis for antiepileptic medication withdrawal following anterior temporal lobectomy for complex partial seizures. Thirty-nine of the 104 patients underwent a trial of complete medication withdrawal following a minimum 1-year seizure-free postoperative period. The likelihood of remaining seizure-free in these 39 patients was 77% at 1 year, 72% at 2 years, and 66% at 3 years. A prolonged duration of epilepsy prior to surgery significantly increased the risk for recurrent seizures. These findings suggest that patients who remain seizure-free following surgery for temporal lobe complex partial seizures have a good prognosis for remaining seizure-free following anti-epileptic medication withdrawal.

Original languageEnglish (US)
Pages (from-to)39-42
Number of pages4
JournalJournal of Epilepsy
Issue number1
Publication statusPublished - Jan 1 1991



  • Anticonvulsants
  • Complex partial seizures
  • Epilepsy
  • Epilepsy surgery
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Murro, A. M., King, D. W., Smith, J. R., Gallagher, B. B., Flanigin, H. F., Loring, D. W., ... Revolinski, P. H. (1991). Withdrawal of antiepileptic medications following epilepsy surgery. Journal of Epilepsy, 4(1), 39-42. https://doi.org/10.1016/0896-6974(91)90121-X