Withdrawal of antiepileptic medications following epilepsy surgery

Anthony M Murro, Don W. King, Joseph R. Smith, Brian B. Gallagher, Herman F. Flanigin, David W. Loring, Gregory P Lee, Rebecca Campbell, Kimford Meador, Patricia H. Revolinski

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

We followed 104 patients to determine the prognosis for antiepileptic medication withdrawal following anterior temporal lobectomy for complex partial seizures. Thirty-nine of the 104 patients underwent a trial of complete medication withdrawal following a minimum 1-year seizure-free postoperative period. The likelihood of remaining seizure-free in these 39 patients was 77% at 1 year, 72% at 2 years, and 66% at 3 years. A prolonged duration of epilepsy prior to surgery significantly increased the risk for recurrent seizures. These findings suggest that patients who remain seizure-free following surgery for temporal lobe complex partial seizures have a good prognosis for remaining seizure-free following anti-epileptic medication withdrawal.

Original languageEnglish (US)
Pages (from-to)39-42
Number of pages4
JournalJournal of Epilepsy
Volume4
Issue number1
DOIs
StatePublished - Jan 1 1991

Keywords

  • Anticonvulsants
  • Complex partial seizures
  • Epilepsy
  • Epilepsy surgery
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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