Withdrawal of antiepileptic medications following epilepsy surgery

Anthony M Murro, Don W. King, Joseph R. Smith, Brian B. Gallagher, Herman F. Flanigin, David W. Loring, Gregory P Lee, Rebecca Campbell, Kimford Meador, Patricia H. Revolinski

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We followed 104 patients to determine the prognosis for antiepileptic medication withdrawal following anterior temporal lobectomy for complex partial seizures. Thirty-nine of the 104 patients underwent a trial of complete medication withdrawal following a minimum 1-year seizure-free postoperative period. The likelihood of remaining seizure-free in these 39 patients was 77% at 1 year, 72% at 2 years, and 66% at 3 years. A prolonged duration of epilepsy prior to surgery significantly increased the risk for recurrent seizures. These findings suggest that patients who remain seizure-free following surgery for temporal lobe complex partial seizures have a good prognosis for remaining seizure-free following anti-epileptic medication withdrawal.

Original languageEnglish (US)
Pages (from-to)39-42
Number of pages4
JournalJournal of Epilepsy
Volume4
Issue number1
DOIs
StatePublished - Jan 1 1991

Fingerprint

Anticonvulsants
Epilepsy
Seizures
Anterior Temporal Lobectomy
Temporal Lobe
Postoperative Period

Keywords

  • Anticonvulsants
  • Complex partial seizures
  • Epilepsy
  • Epilepsy surgery
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Murro, A. M., King, D. W., Smith, J. R., Gallagher, B. B., Flanigin, H. F., Loring, D. W., ... Revolinski, P. H. (1991). Withdrawal of antiepileptic medications following epilepsy surgery. Journal of Epilepsy, 4(1), 39-42. https://doi.org/10.1016/0896-6974(91)90121-X

Withdrawal of antiepileptic medications following epilepsy surgery. / Murro, Anthony M; King, Don W.; Smith, Joseph R.; Gallagher, Brian B.; Flanigin, Herman F.; Loring, David W.; Lee, Gregory P; Campbell, Rebecca; Meador, Kimford; Revolinski, Patricia H.

In: Journal of Epilepsy, Vol. 4, No. 1, 01.01.1991, p. 39-42.

Research output: Contribution to journalArticle

Murro, AM, King, DW, Smith, JR, Gallagher, BB, Flanigin, HF, Loring, DW, Lee, GP, Campbell, R, Meador, K & Revolinski, PH 1991, 'Withdrawal of antiepileptic medications following epilepsy surgery', Journal of Epilepsy, vol. 4, no. 1, pp. 39-42. https://doi.org/10.1016/0896-6974(91)90121-X
Murro AM, King DW, Smith JR, Gallagher BB, Flanigin HF, Loring DW et al. Withdrawal of antiepileptic medications following epilepsy surgery. Journal of Epilepsy. 1991 Jan 1;4(1):39-42. https://doi.org/10.1016/0896-6974(91)90121-X
Murro, Anthony M ; King, Don W. ; Smith, Joseph R. ; Gallagher, Brian B. ; Flanigin, Herman F. ; Loring, David W. ; Lee, Gregory P ; Campbell, Rebecca ; Meador, Kimford ; Revolinski, Patricia H. / Withdrawal of antiepileptic medications following epilepsy surgery. In: Journal of Epilepsy. 1991 ; Vol. 4, No. 1. pp. 39-42.
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