Within the brain: The renin angiotensin system

Ladonya Jackson, Wael Eldahshan, Susan C. Fagan, Adviye Ergul

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

For many years, modulators of the renin angiotensin system (RAS) have been trusted by clinicians for the control of essential hypertension. It was recently demonstrated that these modulators have other pleiotropic properties independent of their hypotensive effects, such as enhancement of cognition. Within the brain, different components of the RAS have been extensively studied in the context of neuroprotection and cognition. Interestingly, a crosstalk between the RAS and other systems such as cholinergic, dopaminergic and adrenergic systems have been demonstrated. In this review, the preclinical and clinical evidence for the impact of RAS modulators on cognitive impairment of multiple etiologies will be discussed. In addition, the expression and function of different receptor subtypes within the RAS such as: Angiotensin II type I receptor (AT1R), Angiotensin II type II receptor (AT2R), Angiotensin IV receptor (AT4R), Mas receptor (MasR), and Mas-related-G protein-coupled receptor (MrgD), on different cell types within the brain will be presented. We aim to direct the attention of the scientific community to the plethora of evidence on the importance of the RAS on cognition and to the different disease conditions in which these agents can be beneficial.

Original languageEnglish (US)
Article number876
JournalInternational journal of molecular sciences
Volume19
Issue number3
DOIs
StatePublished - Mar 15 2018

Fingerprint

renin
angiotensins
Angiotensins
Renin-Angiotensin System
Renin
Modulators
brain
Brain
Cognition
cognition
Crosstalk
modulators
Proteins
Angiotensin I
Angiotensin Receptors
G-Protein-Coupled Receptors
cholinergics
adrenergics
Angiotensin II
Adrenergic Agents

Keywords

  • Aging
  • Alzhemiers disease (AD)
  • Angiotensin
  • Angiotensin AT1 receptor
  • Angiotensin AT2 receptor
  • Inflammation
  • Mas receptor
  • Mas-related-G protein coupled MrgD receptor
  • Microglia
  • Parkinson’s disease (PD)
  • Vascular cognitive impairment (VCI)

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Within the brain : The renin angiotensin system. / Jackson, Ladonya; Eldahshan, Wael; Fagan, Susan C.; Ergul, Adviye.

In: International journal of molecular sciences, Vol. 19, No. 3, 876, 15.03.2018.

Research output: Contribution to journalArticle

Jackson, Ladonya ; Eldahshan, Wael ; Fagan, Susan C. ; Ergul, Adviye. / Within the brain : The renin angiotensin system. In: International journal of molecular sciences. 2018 ; Vol. 19, No. 3.
@article{cb4e34ed612d436f87cfdae076e49885,
title = "Within the brain: The renin angiotensin system",
abstract = "For many years, modulators of the renin angiotensin system (RAS) have been trusted by clinicians for the control of essential hypertension. It was recently demonstrated that these modulators have other pleiotropic properties independent of their hypotensive effects, such as enhancement of cognition. Within the brain, different components of the RAS have been extensively studied in the context of neuroprotection and cognition. Interestingly, a crosstalk between the RAS and other systems such as cholinergic, dopaminergic and adrenergic systems have been demonstrated. In this review, the preclinical and clinical evidence for the impact of RAS modulators on cognitive impairment of multiple etiologies will be discussed. In addition, the expression and function of different receptor subtypes within the RAS such as: Angiotensin II type I receptor (AT1R), Angiotensin II type II receptor (AT2R), Angiotensin IV receptor (AT4R), Mas receptor (MasR), and Mas-related-G protein-coupled receptor (MrgD), on different cell types within the brain will be presented. We aim to direct the attention of the scientific community to the plethora of evidence on the importance of the RAS on cognition and to the different disease conditions in which these agents can be beneficial.",
keywords = "Aging, Alzhemiers disease (AD), Angiotensin, Angiotensin AT1 receptor, Angiotensin AT2 receptor, Inflammation, Mas receptor, Mas-related-G protein coupled MrgD receptor, Microglia, Parkinson’s disease (PD), Vascular cognitive impairment (VCI)",
author = "Ladonya Jackson and Wael Eldahshan and Fagan, {Susan C.} and Adviye Ergul",
year = "2018",
month = "3",
day = "15",
doi = "10.3390/ijms19030876",
language = "English (US)",
volume = "19",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

TY - JOUR

T1 - Within the brain

T2 - The renin angiotensin system

AU - Jackson, Ladonya

AU - Eldahshan, Wael

AU - Fagan, Susan C.

AU - Ergul, Adviye

PY - 2018/3/15

Y1 - 2018/3/15

N2 - For many years, modulators of the renin angiotensin system (RAS) have been trusted by clinicians for the control of essential hypertension. It was recently demonstrated that these modulators have other pleiotropic properties independent of their hypotensive effects, such as enhancement of cognition. Within the brain, different components of the RAS have been extensively studied in the context of neuroprotection and cognition. Interestingly, a crosstalk between the RAS and other systems such as cholinergic, dopaminergic and adrenergic systems have been demonstrated. In this review, the preclinical and clinical evidence for the impact of RAS modulators on cognitive impairment of multiple etiologies will be discussed. In addition, the expression and function of different receptor subtypes within the RAS such as: Angiotensin II type I receptor (AT1R), Angiotensin II type II receptor (AT2R), Angiotensin IV receptor (AT4R), Mas receptor (MasR), and Mas-related-G protein-coupled receptor (MrgD), on different cell types within the brain will be presented. We aim to direct the attention of the scientific community to the plethora of evidence on the importance of the RAS on cognition and to the different disease conditions in which these agents can be beneficial.

AB - For many years, modulators of the renin angiotensin system (RAS) have been trusted by clinicians for the control of essential hypertension. It was recently demonstrated that these modulators have other pleiotropic properties independent of their hypotensive effects, such as enhancement of cognition. Within the brain, different components of the RAS have been extensively studied in the context of neuroprotection and cognition. Interestingly, a crosstalk between the RAS and other systems such as cholinergic, dopaminergic and adrenergic systems have been demonstrated. In this review, the preclinical and clinical evidence for the impact of RAS modulators on cognitive impairment of multiple etiologies will be discussed. In addition, the expression and function of different receptor subtypes within the RAS such as: Angiotensin II type I receptor (AT1R), Angiotensin II type II receptor (AT2R), Angiotensin IV receptor (AT4R), Mas receptor (MasR), and Mas-related-G protein-coupled receptor (MrgD), on different cell types within the brain will be presented. We aim to direct the attention of the scientific community to the plethora of evidence on the importance of the RAS on cognition and to the different disease conditions in which these agents can be beneficial.

KW - Aging

KW - Alzhemiers disease (AD)

KW - Angiotensin

KW - Angiotensin AT1 receptor

KW - Angiotensin AT2 receptor

KW - Inflammation

KW - Mas receptor

KW - Mas-related-G protein coupled MrgD receptor

KW - Microglia

KW - Parkinson’s disease (PD)

KW - Vascular cognitive impairment (VCI)

UR - http://www.scopus.com/inward/record.url?scp=85044133306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044133306&partnerID=8YFLogxK

U2 - 10.3390/ijms19030876

DO - 10.3390/ijms19030876

M3 - Article

AN - SCOPUS:85044133306

VL - 19

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 3

M1 - 876

ER -