Wnt signaling in dendritic cells: Its role in regulation of immunity and tolerance

Daniel Swafford, Santhakumar Manicassamy

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

A fundamental puzzle in immunology is how the immune system launches robust immunity against pathogens while maintaining a state of tolerance to the body's own tissues and the trillions of commensal microorganisms and food antigens that confront them every day. Innate immune cells, such as dendritic cells (DCs) and macrophages, play a fundamental role in this process. Emerging studies have highlighted that the Wnt signaling pathway, particularly in DCs, plays a major role in regulating tolerance versus immunity. Here, we review our current understanding of how Wnt-signaling shapes the immune response and, in addition, highlight unanswered questions, the solution of which will be imperative in the rational exploitation of this pathway in vaccine design and immune therapy.

Original languageEnglish (US)
Pages (from-to)303-310
Number of pages8
JournalDiscovery Medicine
Volume19
Issue number105
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Medicine(all)

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