TY - JOUR
T1 - Wnt signaling in dendritic cells
T2 - Its role in regulation of immunity and tolerance
AU - Swafford, Daniel
AU - Manicassamy, Santhakumar
N1 - Publisher Copyright:
© 2015, Discovery Medicine.
PY - 2015
Y1 - 2015
N2 - A fundamental puzzle in immunology is how the immune system launches robust immunity against pathogens while maintaining a state of tolerance to the body's own tissues and the trillions of commensal microorganisms and food antigens that confront them every day. Innate immune cells, such as dendritic cells (DCs) and macrophages, play a fundamental role in this process. Emerging studies have highlighted that the Wnt signaling pathway, particularly in DCs, plays a major role in regulating tolerance versus immunity. Here, we review our current understanding of how Wnt-signaling shapes the immune response and, in addition, highlight unanswered questions, the solution of which will be imperative in the rational exploitation of this pathway in vaccine design and immune therapy.
AB - A fundamental puzzle in immunology is how the immune system launches robust immunity against pathogens while maintaining a state of tolerance to the body's own tissues and the trillions of commensal microorganisms and food antigens that confront them every day. Innate immune cells, such as dendritic cells (DCs) and macrophages, play a fundamental role in this process. Emerging studies have highlighted that the Wnt signaling pathway, particularly in DCs, plays a major role in regulating tolerance versus immunity. Here, we review our current understanding of how Wnt-signaling shapes the immune response and, in addition, highlight unanswered questions, the solution of which will be imperative in the rational exploitation of this pathway in vaccine design and immune therapy.
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M3 - Article
C2 - 25977193
AN - SCOPUS:84940546828
SN - 1539-6509
VL - 19
SP - 303
EP - 310
JO - Discovery Medicine
JF - Discovery Medicine
IS - 105
ER -