Zoledronate and ion-releasing resins impair dentin collagen degradation

A. Tezvergil-Mutluay, R. Seseogullari-Dirihan, V. P. Feitosa, Franklin Chi Meng Tay, T. F. Watson, D. H. Pashley, S. Sauro

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This study analyzed the amounts of solubilized telopeptides cross-linked carboxyterminal telopeptide of type I collagen (ICTP) and C-terminal crosslinked telopeptide of type I collagen (CTX) derived from matrix-metalloproteinases (MMPs) and cysteine cathepsins (CTPs) subsequent to application of a filler-free (Res.A) or an ion-releasing resin (Res.B) to ethylenediaminetetraacetic acid (EDTA)-demineralized dentin with or without zoledronate-containing primer (Zol-primer) pre-treatment. The chemical modification induced following treatments and artificial saliva (AS) storage was also analyzed through attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). Totally EDTA-demineralized specimens were infiltrated with Res.A or Res.B with or without Zol-primer pre-treatment, light-cured, and immersed in AS for up to 4 wk. ICTP release was reduced following infiltration with Res.B and further reduced when Res.B was used with Zol-primer; remarkable phosphate mineral uptake was attained after AS storage. CTX release was increased in Res.A- and Res.B-treated dentin. However, when Zol-primer was used with Res.A, the CTX release fell significantly compared to the other tested resin-infiltration methods. In conclusion, zoledronate offers an additional inhibitory effect to the ion-releasing resins in MMP-mediated collagen degradation. However, Zol-primer induces a modest reduction in CTX release only when used with resin-based systems containing no ion-releasing fillers.

Original languageEnglish (US)
Pages (from-to)999-1004
Number of pages6
JournalJournal of Dental Research
Volume93
Issue number10
DOIs
StatePublished - Jan 1 2014

Fingerprint

zoledronic acid
Dentin
Collagen
Artificial Saliva
Ions
Matrix Metalloproteinases
Edetic Acid
Cathepsins
Fourier Transform Infrared Spectroscopy
Collagen Type I
Minerals
Cysteine
Phosphates

Keywords

  • bisphosphonates
  • calcium phosphates
  • cathepsins
  • matrix metalloproteinase
  • phosphorylation
  • proteolysis

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Tezvergil-Mutluay, A., Seseogullari-Dirihan, R., Feitosa, V. P., Tay, F. C. M., Watson, T. F., Pashley, D. H., & Sauro, S. (2014). Zoledronate and ion-releasing resins impair dentin collagen degradation. Journal of Dental Research, 93(10), 999-1004. https://doi.org/10.1177/0022034514546043

Zoledronate and ion-releasing resins impair dentin collagen degradation. / Tezvergil-Mutluay, A.; Seseogullari-Dirihan, R.; Feitosa, V. P.; Tay, Franklin Chi Meng; Watson, T. F.; Pashley, D. H.; Sauro, S.

In: Journal of Dental Research, Vol. 93, No. 10, 01.01.2014, p. 999-1004.

Research output: Contribution to journalArticle

Tezvergil-Mutluay, A, Seseogullari-Dirihan, R, Feitosa, VP, Tay, FCM, Watson, TF, Pashley, DH & Sauro, S 2014, 'Zoledronate and ion-releasing resins impair dentin collagen degradation', Journal of Dental Research, vol. 93, no. 10, pp. 999-1004. https://doi.org/10.1177/0022034514546043
Tezvergil-Mutluay A, Seseogullari-Dirihan R, Feitosa VP, Tay FCM, Watson TF, Pashley DH et al. Zoledronate and ion-releasing resins impair dentin collagen degradation. Journal of Dental Research. 2014 Jan 1;93(10):999-1004. https://doi.org/10.1177/0022034514546043
Tezvergil-Mutluay, A. ; Seseogullari-Dirihan, R. ; Feitosa, V. P. ; Tay, Franklin Chi Meng ; Watson, T. F. ; Pashley, D. H. ; Sauro, S. / Zoledronate and ion-releasing resins impair dentin collagen degradation. In: Journal of Dental Research. 2014 ; Vol. 93, No. 10. pp. 999-1004.
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KW - phosphorylation

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