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2020

Accumulation of kynurenine elevates oxidative stress and alters microRNA profile in human bone marrow stromal cells

Dalton, S., Smith, K., Singh, K., Kaiser, H., Kolhe, R., Mondal, A. K., Khayrullin, A., Isales, C. M., Hamrick, M. W., Hill, W. D. & Fulzele, S., Feb 2020, In : Experimental Gerontology. 130, 110800.

Research output: Contribution to journalArticle

3 Scopus citations

Adenosine kinase inhibition enhances microvascular dilator function and improves left ventricle diastolic dysfunction

Davila, A., Tian, Y., Czikora, I., S. Weissman, A., Weinand, N., Dong, G., Xu, J., Li, J., Su, H., Kapuku, G., Huo, Y. & Bagi, Z., Jan 1 2020, (Accepted/In press) In : Microcirculation.

Research output: Contribution to journalArticle

Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells

Elmansi, A. M., Hussein, K. A., Herrero, S. M., Periyasamy-Thandavan, S., Aguilar-Pérez, A., Kondrikova, G., Kondrikov, D., Eisa, N. H., Pierce, J. L., Kaiser, H., Ding, K. H., Walker, A. L., Jiang, X., Bollag, W. B., Elsalanty, M., Zhong, Q., Shi, X. M., Su, Y., Johnson, M., Hunter, M. & 7 others, Reitman, C., Volkman, B. F., Hamrick, M. W., Isales, C. M., Fulzele, S., McGee-Lawrence, M. E. & Hill, W. D., Jun 2020, In : Bone Reports. 12, 100270.

Research output: Contribution to journalArticle

Open Access

Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats

Wang, Y., Zhang, H., Wang, Z., Wei, Y., Wang, M., Liu, M., Wang, X., Jiang, Y., Shi, G., Zhao, D., Yang, Z., Ren, Z., Li, J., Zhang, Z., Wang, Z., Zhang, B., Zong, B., Lou, X., Liu, C., Wang, Z. & 23 others, Zhang, H., Tao, N., Li, X., Zhang, X., Guo, Y., Ye, Y., Qi, Y., Li, H., Wang, M., Guo, R., Cheng, G., Li, S., Zhang, J., Liu, G., Chai, L., Lou, Q., Li, X., Cui, X., Gao, E., Dong, Z., Hu, Y., Chen, Y. H. & Ma, Y., Apr 22 2020, In : Science Translational Medicine. 12, 540, eaaw3172.

Research output: Contribution to journalArticle

Canagliflozin reduces cisplatin uptake and activates Akt to protect against cisplatin-induced nephrotoxicity

Song, Z., Zhu, J., Wei, Q., Dong, G. & Dong, Z., Apr 1 2020, In : American journal of physiology. Renal physiology. 318, 4, p. F1041-F1052

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Cre/loxP approach-mediated downregulation of Pik3c3 inhibits the hypertrophic growth of renal proximal tubule cells

Liu, T., Yuan, J., Dai, C., Xu, J., Li, S., Humphreys, B. D., Kleven, D. T. & Chen, J. K., 2020, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton

Hagan, M. L., Yu, K., Zhu, J., Vinson, B. N., Roberts, R. L., Montesinos Cartagena, M., Johnson, M. H., Wang, L., Isales, C. M., Hamrick, M. W., McNeil, P. L. & McGee-Lawrence, M. E., Jan 1 2020, In : Aging Cell. 19, 1, e13056.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Deficiency in the endocytic adaptor proteins PHETA1/2 impairs renal and craniofacial development

Ates, K. M., Wang, T., Moreland, T., Veeranan-Karmegam, R., Ma, M., Jeter, C., Anand, P., Wenzel, W., Kim, H. G., Wolfe, L. A., Stephen, J., Adams, D. R., Markello, T., Tifft, C. J., Settlage, R., Gahl, W. A., Gonsalvez, G. B., Malicdan, M. C., Flanagan-Steet, H. & Albert Pan, Y., May 2020, In : DMM Disease Models and Mechanisms. 13, 5, dmm041913.

Research output: Contribution to journalArticle

Open Access

Deletion of PPARγin Mesenchymal Lineage Cells Protects Against Aging-Induced Cortical Bone Loss in Mice

Cao, J., Ding, K., Pan, G., Rosario, R., Su, Y., Bao, Y., Zhou, H., Xu, J., McGee Lawrence, M. E., Hamrick, M. W., Isales, C. M. & Shi, X., Apr 17 2020, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 75, 5, p. 826-834 9 p.

Research output: Contribution to journalArticle

Dioleoylphosphatidylglycerol accelerates corneal epithelial wound healing

Bollag, W. B., Olala, L. O., Xie, D., Lu, X., Qin, H., Choudhary, V., Patel, R., Bogorad, D., Estes, A. & Watsky, M., Mar 2020, In : Investigative Ophthalmology and Visual Science. 61, 3, 29.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Effects of Vitamin D receptor knockout and Vitamin D deficiency on corneal epithelial wound healing and nerve density in diabetic mice

Lu, X., Vick, S., Chen, Z., Chen, J. & Watsky, M. A., May 1 2020, In : Diabetes. 69, 5, p. 1042-1051 10 p.

Research output: Contribution to journalArticle

Expression of mRNAs, miRNAs, and lncRNAs in human trabecular meshwork cells upon mechanical stretch

Youngblood, H., Cai, J., Drewry, M. D., Helwa, I., Hu, E., Liu, S., Yu, H., Mu, H., Hu, Y., Perkumas, K., Aboobakar, I. F., Johnson, W. M., Stamer, W. D. & Liu, Y., May 1 2020, In : Investigative Ophthalmology and Visual Science. 61, 5, A21.

Research output: Contribution to journalArticle

Open Access

Freeze-Dried Extracellular Vesicles From Adipose-Derived Stem Cells Prevent Hypoxia-Induced Muscle Cell Injury

El Baradie, K. B. Y., Nouh, M., O’Brien, F., Liu, Y., Fulzele, S., Eroglu, A. & Hamrick, M. W., Mar 20 2020, In : Frontiers in Cell and Developmental Biology. 8, 181.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Implementation and evaluation of a near-peer-facilitated medical ethics curriculum for first-year medical students: a pilot study

DeFoor, M. T., East, L., Mann, P. C. & Nichols, C. A., Mar 1 2020, In : Medical Science Educator. 30, 1, p. 219-225 7 p.

Research output: Contribution to journalArticle

Irisin is induced in renal ischemia-reperfusion to protect against tubular cell injury via suppressing p53

Liu, Y., Fu, Y., Liu, Z., Shu, S., Wang, Y., Cai, J., Tang, C. & Dong, Z., Jul 1 2020, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1866, 7, 165792.

Research output: Contribution to journalArticle

Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway

Kondrikov, D. Y., Elmansi, A., Bragg, R. T., Mobley, T., Barrett, T., Eisa, N., Kondrikova, G., Schoeinlein, P., Aguilar-Perez, A., Shi, X. M., Fulzele, S., Lawrence, M. M. G., Hamrick, M., Isales, C. & Hill, W. D., Feb 2020, In : Experimental Gerontology. 130, 110805.

Research output: Contribution to journalArticle

6 Scopus citations

Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo

Pierce, J. L., Roberts, R. L., Yu, K., Kendall, R. K., Kaiser, H., Davis, C., Johnson, M. H., Hill, W. D., Isales, C. M., Bollag, W. B., Hamrick, M. W. & McGee-Lawrence, M. E., Feb 2020, In : Experimental Gerontology. 130, 110818.

Research output: Contribution to journalArticle

1 Scopus citations

MiR-20a-containing exosomes from umbilical cord mesenchymal stem cells alleviates liver ischemia/reperfusion injury

Zhang, L., Song, Y., Chen, L., Li, D., Feng, H., Lu, Z., Fan, T., Chen, Z., Livingston, M. J. & Geng, Q., Apr 1 2020, In : Journal of Cellular Physiology. 235, 4, p. 3698-3710 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

MiR-214 represses mitofusin-2 to promote renal tubular apoptosis in ischemic acute kidney injury

Yan, Y., Ma, Z., Zhu, J., Zeng, M., Liu, H. & Dong, Z., Apr 2020, In : American Journal of Physiology - Renal Physiology. 318, 4, p. F878-F887

Research output: Contribution to journalArticle

2 Scopus citations

Ocular cytomegalovirus latency exacerbates the development of choroidal neovascularization

Xu, J., Liu, X., Zhang, X., Marshall, B., Dong, Z., Liu, Y., Espinosa-Heidmann, D. G. & Zhang, M., Jun 1 2020, In : Journal of Pathology. 251, 2, p. 200-212 13 p.

Research output: Contribution to journalArticle

Picolinic acid, a tryptophan oxidation product, does not impact bone mineral density but increases marrow adiposity

Ding, K., McGee-Lawrence, M. E., Kaiser, H., Sharma, A. K., Pierce, J. L., Irsik, D. L., Bollag, W. B., Xu, J., Zhong, Q., Hill, W. D., Shi, X. M., Fulzele, S., Kennedy, E. J., Elsalanty, M. E., Hamrick, M. W. & Isales, C. M., May 2020, In : Experimental Gerontology. 133, 110885.

Research output: Contribution to journalArticle

1 Scopus citations

Protein Kinase C-δ Mediates Kidney Tubular Injury in Cold Storage-Associated Kidney Transplantation

Zhu, J., Zhang, G., Song, Z., Xiang, X., Shu, S., Liu, Z., Yang, D., Wei, Q. & Dong, Z., May 1 2020, In : Journal of the American Society of Nephrology : JASN. 31, 5, p. 1050-1065 16 p.

Research output: Contribution to journalArticle

1 Scopus citations

Qupath automated analysis of optic nerve degeneration in brown Norway rats

Mysona, B. A., Segar, S., Hernandez, C., Kim, C., Zhao, J., Mysona, D. & Bollinger, K. E., 2020, In : Translational Vision Science and Technology. 9, 3, 22.

Research output: Contribution to journalArticle

Open Access

The Biomarker TCONS_00016233 Drives Septic AKI by Targeting the miR-22-3p/AIFM1 Signaling Axis

Zhang, P., Yi, L., Qu, S., Dai, J., Li, X., Liu, B., Li, H., Ai, K., Zheng, P., Qiu, S., Li, Y., Wang, Y., Xiang, X., Chai, X., Dong, Z. & Zhang, D., Mar 6 2020, In : Molecular Therapy - Nucleic Acids. 19, p. 1027-1042 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors

Khambu, B., Hong, H., Liu, S., Liu, G., Chen, X., Dong, Z., Wan, J. & Yin, X. M., May 1 2020, In : Cell Death and Disease. 11, 5, 333.

Research output: Contribution to journalArticle

Open Access

Therapeutic application of extracellular vesicles for musculoskeletal repair & regeneration

Youssef El Baradie, K. B. & Hamrick, M. W., 2020, (Accepted/In press) In : Connective Tissue Research.

Research output: Contribution to journalArticle

The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice

Sharma, A. K., Roberts, R. L., Benson, R. D., Pierce, J. L., Yu, K., Hamrick, M. W. & McGee-Lawrence, M. E., May 20 2020, In : Frontiers in Cell and Developmental Biology. 8, 354.

Research output: Contribution to journalArticle

Open Access

The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress

Lee, H., Smith, S. B., Sheu, S. S. & Yoon, Y., May 8 2020, In : Journal of Biological Chemistry. 295, 19, p. 6543-6560 18 p.

Research output: Contribution to journalArticle

Open Access
Open Access

Transient Cell Membrane Disruptions induce Calcium Waves in Corneal Keratocytes

Chen, Z., Lu, X., McGee-Lawrence, M. E. & Watsky, M. A., Dec 1 2020, In : Scientific reports. 10, 1, 2840.

Research output: Contribution to journalArticle

Open Access

Utility of LysM-Cre and CdH5-Cre driver mice in retinal and brain research: An imaging study using tdtomato reporter mouse

Fouda, A. Y., Xu, Z., Priya Narayanan, S., William Caldwell, R. & Caldwell, R. B., Mar 2020, In : Investigative Ophthalmology and Visual Science. 61, 3, 51.

Research output: Contribution to journalArticle

Open Access

Variations in Healthy Swallowing Mechanics During Various Bolus Conditions Using Computational Analysis of Swallowing Mechanics (CASM)

Lenell, C., Brates, D., Pearson, W. G. & Molfenter, S., Apr 1 2020, In : Dysphagia. 35, 2, p. 272-280 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Vitamin C is a source of oxoaldehyde and glycative stress in age-related cataract and neurodegenerative diseases

Fan, X., Sell, D. R., Hao, C., Liu, S., Wang, B., Wesson, D. W., Siedlak, S., Zhu, X., Kavanagh, T. J., Harrison, F. E. & Monnier, V. M., Jul 1 2020, In : Aging Cell. 19, 7, ACEL13176.

Research output: Contribution to journalArticle

Open Access
2019

3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT2B, 5-HT7, or σ1 Receptor Ligands

Porter, M. R., Xiao, H., Wang, J., Smith, S. B. & Topczewski, J. J., Oct 10 2019, In : ACS Medicinal Chemistry Letters. 10, 10, p. 1436-1442 7 p.

Research output: Contribution to journalArticle

Aberrant DNA methylation of mTOR pathway genes promotes inflammatory activation of immune cells in diabetic kidney disease

Chen, G., Chen, H., Ren, S., Xia, M., Zhu, J., Liu, Y., Zhang, L., Tang, L., Sun, L., Liu, H. & Dong, Z., Aug 2019, In : Kidney International. 96, 2, p. 409-420 12 p.

Research output: Contribution to journalArticle

9 Scopus citations
Open Access
1 Scopus citations
4 Scopus citations

Age-dependent oxidative stress elevates arginase 1 and uncoupled nitric oxide synthesis in skeletal muscle of aged mice

Pandya, C. D., Lee, B., Toque, H. A., Mendhe, B., Bragg, R. T., Pandya, B., Atawia, R. T., Isales, C., Hamrick, M., Caldwell, R. W. & Fulzele, S., 2019, In : Oxidative medicine and cellular longevity. 2019, 1704650.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Association of a Primary Open-Angle Glaucoma Genetic Risk Score with Earlier Age at Diagnosis

Fan, B. J., Bailey, J. C., Igo, R. P., Kang, J. H., Boumenna, T., Brilliant, M. H., Budenz, D. L., Fingert, J. H., Gaasterland, T., Gaasterland, D., Hauser, M. A., Kraft, P., Lee, R. K., Lichter, P. R., Liu, Y., Moroi, S. E., Myers, J. S., Pericak-Vance, M. A., Realini, A., Rhee, D. J. & 13 others, Richards, J. E., Ritch, R., Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Vollrath, D., Weinreb, R. N., Wollstein, G., Zack, D. J., Haines, J. L., Pasquale, L. R. & Wiggs, J. L., Oct 2019, In : JAMA Ophthalmology. 137, 10, p. 1190-1194 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture

Kim, B. J., Yoo, H. J., Park, S. J., Kwak, M. K., Lee, S. H., Kim, S. J., Hamrick, M. W., Isales, C. M., Ahn, S. H. & Koh, J. M., May 1 2019, In : Osteoporosis International. 30, 5, p. 1071-1078 8 p.

Research output: Contribution to journalArticle

Association of Genetic Variants with Primary Open-Angle Glaucoma among Individuals with African Ancestry

Hauser, M. A., Allingham, R. R., Aung, T., Van Der Heide, C. J., Taylor, K. D., Rotter, J. I., Wang, S. H. J., Bonnemaijer, P. W. M., Williams, S. E., Abdullahi, S. M., Abu-Amero, K. K., Anderson, M. G., Akafo, S., Alhassan, M. B., Asimadu, I., Ayyagari, R., Bakayoko, S., Nyamsi, P. B., Bowden, D. W., Bromley, W. C. & 73 others, Budenz, D. L., Carmichael, T. R., Challa, P., Chen, Y. D. I., Chuka-Okosa, C. M., Cooke Bailey, J. N., Costa, V. P., Cruz, D. A., Dubiner, H., Ervin, J. F., Feldman, R. M., Flamme-Wiese, M., Gaasterland, D. E., Garnai, S. J., Girkin, C. A., Guirou, N., Guo, X., Haines, J. L., Hammond, C. J., Herndon, L., Hoffmann, T. J., Hulette, C. M., Hydara, A., Igo, R. P., Jorgenson, E., Kabwe, J., Kilangalanga, N. J., Kizor-Akaraiwe, N., Kuchtey, R. W., Lamari, H., Li, Z., Liebmann, J. M., Liu, Y., Loos, R. J. F., Melo, M. B., Moroi, S. E., Msosa, J. M., Mullins, R. F., Nadkarni, G., Napo, A., Ng, M. C. Y., Nunes, H. F., Obeng-Nyarkoh, E., Okeke, A., Okeke, S., Olaniyi, O., Olawoye, O., Oliveira, M. B., Pasquale, L. R., Perez-Grossmann, R. A., Pericak-Vance, M. A., Qin, X., Ramsay, M., Resnikoff, S., Richards, J. E., Schimiti, R. B., Sim, K. S., Sponsel, W. E., Svidnicki, P. V., Thiadens, A. A. H. J., Uche, N. J., Van Duijn, C. M., De Vasconcellos, J. P. C., Wiggs, J. L., Zangwill, L. M., Risch, N., Milea, D., Ashaye, A., Klaver, C. C. W., Weinreb, R. N., Ashley Koch, A. E., Fingert, J. H. & Khor, C. C., Nov 5 2019, In : JAMA - Journal of the American Medical Association. 322, 17, p. 1682-1691 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis

Cho, S. G., Xiao, X., Wang, S., Gao, H., Rafikov, R., Black, S., Huang, S., Ding, H. F., Yoon, Y., Kirken, R. A., Yin, X. M., Wang, H. G. & Dong, Z., Jul 2019, In : Journal of the American Society of Nephrology. 30, 7, p. 1174-1191 18 p.

Research output: Contribution to journalArticle

5 Scopus citations

Chronic effects of repeated low-dose cisplatin treatment in mouse kidneys and renal tubular cells

Fu, Y., Cai, J., Li, F., Liu, Z., Shu, S., Wang, Y., Liu, Y., Tang, C. & Dong, Z., 2019, In : American Journal of Physiology - Renal Physiology. 317, 6, p. F1582-F1592

Research output: Contribution to journalArticle

Chronic mild stress induced anxiety-like behaviors can Be attenuated by inhibition of NOX2-derived oxidative stress

Lv, H., Zhu, C., Wu, R., Ni, H., Lian, J., Xu, Y., Xia, Y., Shi, G., Li, Z., Caldwell, R. B., Caldwell, R. W., Yao, L. & Chen, Y., Jul 2019, In : Journal of Psychiatric Research. 114, p. 55-66 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

Livingston, M. J., Wang, J., Zhou, J., Wu, G., Ganley, I. G., Hill, J. A., Yin, X. M. & Dong, Z., Dec 2 2019, In : Autophagy. 15, 12, p. 2142-2162 21 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Commonly used adjuvants (liquid soap, foam sanitizer, or ultrasound gel) do not improve strength or curing time of fiberglass cast material

Meng, M. R. I., Elphingstone, J. W., Sinkler, M. A., Byrd, B. M. & McGee-Lawrence, M. E., May 30 2019, In : Journal of Orthopaedic Surgery and Research. 14, 1, 166.

Research output: Contribution to journalArticle

Open Access

Defining osteoblast and adipocyte lineages in the bone marrow

Pierce, J. L., Begun, D. L., Westendorf, J. J. & McGee-Lawrence, M. E., Jan 2019, In : Bone. 118, p. 2-7 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Deletion of Arginase 2 Ameliorates Retinal Neurodegeneration in a Mouse Model of Multiple Sclerosis

Palani, C. D., Fouda, A. Y., Liu, F., Xu, Z., Mohamed, E., Giri, S., Smith, S. B., Caldwell, R. B. & Narayanan, S. P., Dec 1 2019, In : Molecular Neurobiology. 56, 12, p. 8589-8602 14 p.

Research output: Contribution to journalArticle