• 3771 Citations
  • 31 h-Index
19962020

Research output per year

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Research Output

2020
1 Scopus citations
2019

A Naturally Occurring Splice Variant of GGA1 Inhibits the Anterograde Post-Golgi Traffic of α2B-Adrenergic Receptor

Zhang, M., Xu, X., Li, C., Huang, W., Xu, N. & Wu, G., Dec 1 2019, In : Scientific reports. 9, 1, 10378.

Research output: Contribution to journalArticle

Open Access

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

Livingston, M. J., Wang, J., Zhou, J., Wu, G., Ganley, I. G., Hill, J. A., Yin, X. M. & Dong, Z., Dec 2 2019, In : Autophagy. 15, 12, p. 2142-2162 21 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2

Li, Z. W., Sun, B., Gong, T., Guo, S., Zhang, J., Wang, J., Sugawara, A., Jiang, M., Yan, J., Gurary, A., Zheng, X., Gao, B., Xiao, S. Y., Chen, W., Ma, C., Farrar, C., Zhu, C., Chan, O. T. M., Xin, C., Winnicki, A. & 24 others, Winnicki, J., Tang, M., Park, R., Winnicki, M., Diener, K., Wang, Z., Liu, Q., Chu, C. H., Arter, Z. L., Yue, P., Alpert, L., Hui, G. S., Fei, P., Turkson, J., Yang, W., Wu, G., Tao, A., Ramos, J. W., Moisyadi, S., Holcombe, R. F., Jia, W., Birnbaumer, L., Zhou, X. & Chu, W. M., Jun 2019, In : Gastroenterology. 156, 8, p. 2297-2312 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

Mechanisms of the anterograde trafficking of GPCRs: Regulation of AT1R transport by interacting proteins and motifs

Zhang, M. & Wu, G., Feb 1 2019, In : Traffic. 20, 2, p. 110-120 11 p.

Research output: Contribution to journalReview article

5 Scopus citations

Specific TBC Domain-Containing Proteins Control the ER-Golgi-Plasma Membrane Trafficking of GPCRs

Wei, Z., Zhang, M., Li, C., Huang, W., Fan, Y., Guo, J., Khater, M., Fukuda, M., Dong, Z., Hu, G. & Wu, G., Jul 9 2019, In : Cell Reports. 28, 2, p. 554-566.e4

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The GTPase Rab1 is required for NLRP3 inflammasome activation and inflammatory lung injury

Zhang, Y., Wang, L., Lv, Y., Jiang, C., Wu, G., Dull, R. O., Minshall, R. D., Malik, A. B. & Hu, G., Jan 1 2019, In : Journal of Immunology. 202, 1, p. 194-206 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3

Du, R. H., Lu, M., Wang, C., Ding, J. H., Wu, G. & Hu, G., Aug 1 2019, In : Experimental and Molecular Medicine. 51, 8, 92.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells

Liu, J., Livingston, M. J., Dong, G., Tang, C., Su, Y., Wu, G., Yin, X. M. & Dong, Z., Mar 1 2018, In : Cell Death and Disease. 9, 3, 322.

Research output: Contribution to journalArticle

25 Scopus citations

RAB26-dependent autophagy protects adherens junctional integrity in acute lung injury

Dong, W., He, B., Qian, H., Liu, Q., Wang, D., Li, J., Wei, Z., Wang, Z., Xu, Z., Wu, G., Qian, G. & Wang, G., Oct 3 2018, In : Autophagy. 14, 10, p. 1677-1692 16 p.

Research output: Contribution to journalArticle

19 Scopus citations

Regulation of SAP102 Synaptic Targeting by Phosphorylation

Wei, Z., Wu, G. & Chen, B. S., Aug 1 2018, In : Molecular Neurobiology. 55, 8, p. 6215-6226 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Role of Rab GTPases in the export trafficking of G protein-coupled receptors

Wang, G., Wei, Z. & Wu, G., Mar 4 2018, In : Small GTPases. 9, 1-2, p. 130-135 6 p.

Research output: Contribution to journalReview article

8 Scopus citations

The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation

Wang, S., Liu, A., Wu, G., Ding, H. F., Huang, S., Nahman, S. & Dong, Z., Dec 1 2018, In : Nature communications. 9, 1, 1234.

Research output: Contribution to journalArticle

5 Scopus citations
2017
6 Scopus citations

Chlorpyrifos and chlorpyrifos oxon impair the transport of membrane bound organelles in rat cortical axons

Gao, J., Naughton, S. X., Beck, W. D., Hernandez, C. M., Wu, G., Wei, Z., Yang, X., Bartlett, M. G. & Terry, A. V., Sep 2017, In : NeuroToxicology. 62, p. 111-123 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Epithelial sodium channel-α mediates the protective effect of the TNF-derived TIP peptide in pneumolysin-induced endothelial barrier dysfunction

Czikora, I., Alli, A. A., Sridhar, S., Matthay, M. A., Pillich, H., Hudel, M., Berisha, B., Gorshkov, B. A., Romero Lucas, M. J., Gonzales, J. N., Wu, G., Huo, Y., Su, Y., Verin, A. D., Fulton, D. J., Chakraborty, T., Eaton, D. C. & Lucas, R., Jul 21 2017, In : Frontiers in immunology. 8, JUL, 842.

Research output: Contribution to journalArticle

13 Scopus citations

MicroRNA-375 is induced in cisplatin nephrotoxicity to repress hepatocyte nuclear factor 1-β

Hao, J., Lou, Q., Wei, Q., Mei, S., Li, L., Wu, G., Mi, Q. S., Mei, C. & Dong, Z., Mar 17 2017, In : Journal of Biological Chemistry. 292, 11, p. 4571-4582 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

The GTPase Rab43 Controls the Anterograde ER-Golgi Trafficking and Sorting of GPCRs

Li, C., Wei, Z., Fan, Y., Huang, W., Su, Y., Li, H., Dong, Z., Fukuda, M., Khater, M. & Wu, G., Oct 24 2017, In : Cell Reports. 21, 4, p. 1089-1101 13 p.

Research output: Contribution to journalArticle

15 Scopus citations
2016

ARF1 promotes prostate tumorigenesis via targeting oncogenic MAPK signaling

Davis, J. E., Xie, X., Guo, J., Huang, W., Chu, W. M., Huang, S., Teng, Y. & Wu, G., 2016, In : Oncotarget. 7, 26, p. 39834-39845 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

GGA3 interacts with a G protein-coupled receptor and modulates its cell surface export

Zhang, M., Davis, J. E., Li, C., Gao, J., Huang, W., Lambert, N. A., Terry, A. V. & Wu, G., Apr 1 2016, In : Molecular and Cellular Biology. 36, 7, p. 1152-1163 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2

Zhang, M., Huang, W., Gao, J., Terry, A. V. & Wu, G., Nov 30 2016, In : Scientific reports. 6, 37921.

Research output: Contribution to journalArticle

9 Scopus citations

Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1

Xie, X., Tang, S. C., Cai, Y., Pi, W., Deng, L., Wu, G., Chavanieu, A. & Teng, Y., 2016, In : Oncotarget. 7, 36, p. 58111-58120 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression

Du, R. H., Wu, F. F., Lu, M., Shu, X. D., Ding, J. H., Wu, G. & Hu, G., Oct 1 2016, In : Redox Biology. 9, p. 178-187 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2015

A single mutation in helix 8 enhances the angiotensin II type 1a receptor transport and signaling

Zhu, S., Zhang, M., Davis, J. E., Wu, W. H., Surrao, K., Wang, H. & Wu, G., Dec 1 2015, In : Cellular Signalling. 27, 12, p. 2371-2379 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

BRET evidence that β2 adrenergic receptors do not oligomerize in cells

Lan, T. H., Liu, Q., Li, C., Wu, G., Steyaert, J. & Lambert, N. A., May 8 2015, In : Scientific reports. 5, 10166.

Research output: Contribution to journalArticle

28 Scopus citations

Lateral diffusion contributes to FRET from lanthanide-tagged membrane proteins

Lan, T. H., Wu, G. & Lambert, N. A., Jul 20 2015, In : Biochemical and Biophysical Research Communications. 464, 1, p. 244-248 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Preface

Wu, G., 2015, In : Progress in Molecular Biology and Translational Science. 132, p. xiii

Research output: Contribution to journalEditorial

Rab5-mediated VE-cadherin internalization regulates the barrier function of the lung microvascular endothelium

Yang, J., Yao, W., Qian, G., Wei, Z., Wu, G. & Wang, G., Dec 1 2015, In : Cellular and Molecular Life Sciences. 72, 24, p. 4849-4866 18 p.

Research output: Contribution to journalArticle

21 Scopus citations

Regulation of α2B-adrenerigc receptor export trafficking by specific motifs

Wu, G., Davis, J. E. & Zhang, M., 2015, Trafficking of GPCRs, 2015. Wu, G. (ed.). Elsevier B.V., p. 227-244 18 p. (Progress in Molecular Biology and Translational Science; vol. 132).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Regulation of β-adrenergic receptor trafficking and lung microvascular endothelial cell permeability by Rab5 GTPase

Yang, J., Sun, H., Zhang, J., Hu, M., Wang, J., Wu, G. & Wang, G., Jun 1 2015, In : International Journal of Biological Sciences. 11, 8, p. 868-878 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

ROS and endothelial nitric oxide synthase (eNOS)-dependent trafficking of angiotensin II type 2 receptor begets neuronal NOS in cardiac myocytes

Jang, J. H., Chun, J. N., Godo, S., Wu, G., Shimokawa, H., Jin, C. Z., Jeon, J. H., Kim, S. J., Jin, Z. H. & Zhang, Y. H., May 1 2015, In : Basic Research in Cardiology. 110, 3

Research output: Contribution to journalArticle

16 Scopus citations

The mechanism and function of mitogen-activated protein kinase activation by ARF1

Zhou, F., Dong, C., Davis, J. E., Wu, W. H., Surrao, K. & Wu, G., Oct 1 2015, In : Cellular Signalling. 27, 10, p. 2035-2044 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Trafficking of GPCRs. Preface

Wu, G., Jan 1 2015, In : Progress in molecular biology and translational science. 132, p. xiii

Research output: Contribution to journalEditorial

2014

Anterograde trafficking of KCa3.1 in polarized epithelia is Rab1- And Rab8-Dependent and recycling endosome-independent

Bertuccio, C. A., Lee, S. L., Wu, G., Butterworth, M. B., Hamilton, K. L. & Devor, D. C., Mar 14 2014, In : PloS one. 9, 3, e92013.

Research output: Contribution to journalArticle

16 Scopus citations

Endothelin-1/Endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis

Teoh, J. P., Park, K. M., Wang, Y., Hu, Q., Kim, S., Wu, G., Huang, S., Maihle, N. J. & Kim, I., Sep 3 2014, In : Cellular Signalling. 26, 12, p. 2885-2895 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2013

G-protein-coupled receptor interaction with small GTPases

Dong, C. & Wu, G., 2013, G Protein Coupled ReceptorsModeling, Activation, Interactions and Virtual Screening. Academic Press Inc., p. 97-108 12 p. (Methods in Enzymology; vol. 522).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Identification of endoplasmic reticulum export motifs for G protein-coupled receptors

Wu, G., 2013, G Protein Coupled ReceptorsTrafficking and Oligomerization. Academic Press Inc., p. 189-202 14 p. (Methods in Enzymology; vol. 521).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

The Angiotensin II Type 1 Receptor C-Terminal Lys Residues Interact with Tubulin and Modulate Receptor Export Trafficking

Zhang, X., Wang, H., Duvernay, M. T., Zhu, S. & Wu, G., Feb 25 2013, In : PloS one. 8, 2, e57805.

Research output: Contribution to journalArticle

8 Scopus citations
2012

A Single Lys Residue on the First Intracellular Loop Modulates the Endoplasmic Reticulum Export and Cell-Surface Expression of α2A-Adrenergic Receptor

Fan, Y., Li, C., Guo, J., Hu, G. & Wu, G., Dec 5 2012, In : PloS one. 7, 12, e50416.

Research output: Contribution to journalArticle

5 Scopus citations

A Triple Arg Motif Mediates α 2B-Adrenergic Receptor Interaction with Sec24C/D and Export

Dong, C., Nichols, C. D., Guo, J., Huang, W., Lambert, N. A. & Wu, G., Jun 2012, In : Traffic. 13, 6, p. 857-868 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Rab26 modulates the cell surface transport of α2- adrenergic receptors from the Golgi

Li, C., Fan, Y., Lan, T. H., Lambert, N. A. & Wu, G., Dec 14 2012, In : Journal of Biological Chemistry. 287, 51, p. 42784-42794 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Regulation of post-golgi traf fic of G protein-coupled receptors

Wu, G., May 29 2012, In : Subcellular Biochemistry. 63, p. 83-95 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Sensitive and High Resolution Localization and Tracking of Membrane Proteins in Live Cells with BRET

Lan, T. H., Liu, Q., Li, C., Wu, G. & Lambert, N. A., Nov 2012, In : Traffic. 13, 11, p. 1450-1456 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Small GTPase regulation of GPCR anterograde trafficking

Wang, G. & Wu, G., Jan 2012, In : Trends in Pharmacological Sciences. 33, 1, p. 28-34 7 p.

Research output: Contribution to journalReview article

40 Scopus citations
2011

Anterograde Trafficking of Nascent α2B-Adrenergic Receptor: Structural Basis, Roles of Small GTPases

Dong, C. & Wu, G., 2011, In : Current Topics in Membranes. 67, p. 79-100 22 p.

Research output: Contribution to journalArticle

2 Scopus citations

Di-acidic motifs in the membrane-distal C termini modulate the transport of angiotensin II receptors from the endoplasmic reticulum to the cell surface

Zhang, X., Dong, C., Wu, Q. J., Balch, W. E. & Wu, G., Jun 10 2011, In : Journal of Biological Chemistry. 286, 23, p. 20525-20535 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Discovering G protein-coupled receptor motifs mediating export from the endoplasmic reticulum

Dong, C. & Wu, G., Aug 4 2011, Methods for the Discovery and Characterization of G Protein-Coupled Receptors. Stevens, C. W. (ed.). p. 153-166 14 p. (Neuromethods; vol. 60).

Research output: Chapter in Book/Report/Conference proceedingChapter

Inactive-state preassembly of Gq-coupled receptors and G q heterotrimers

Qin, K., Dong, C., Wu, G. & Lambert, N. A., Oct 2011, In : Nature Chemical Biology. 7, 10, p. 740-747 8 p.

Research output: Contribution to journalArticle

90 Scopus citations

Rab1 GTPase regulates phenotypic modulation of pulmonary artery smooth muscle cells by mediating the transport of angiotensin II type 1 receptor under hypoxia

Yin, H., Li, Q., Qian, G., Wang, Y., Li, Y., Wu, G. & Wang, G., Mar 2011, In : International Journal of Biochemistry and Cell Biology. 43, 3, p. 401-408 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Regulation of α 2B-adrenergic receptor-mediated extracellular signal-regulated kinase 1/2 (ERK1/2) activation by ADP-ribosylation factor 1

Dong, C., Li, C. & Wu, G., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43361-43369 9 p.

Research output: Contribution to journalArticle

18 Scopus citations