• 3591 Citations
  • 31 h-Index
19962019
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Research Output 1996 2019

2019

A Naturally Occurring Splice Variant of GGA1 Inhibits the Anterograde Post-Golgi Traffic of α2B-Adrenergic Receptor

Zhang, M., Xu, X., Li, C., Huang, W., Xu, N. & Wu, G., Dec 1 2019, In : Scientific Reports. 9, 1, 10378.

Research output: Contribution to journalArticle

Open Access
Adrenergic Receptors
Clathrin
G-Protein-Coupled Receptors
ADP-Ribosylation Factors
trans-Golgi Network
1 Citation (Scopus)

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

Livingston, M. J., Wang, J., Zhou, J., Wu, G., Ganley, I. G., Hill, J. A., Yin, X. M. & Dong, Z., Dec 2 2019, In : Autophagy. 15, 12, p. 2142-2162 21 p.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Degradation
Ischemic Preconditioning
Mitochondria
Autophagy
Kidney
3 Citations (Scopus)

Mechanisms of the anterograde trafficking of GPCRs: Regulation of AT1R transport by interacting proteins and motifs

Zhang, M. & Wu, G., Feb 1 2019, In : Traffic. 20, 2, p. 110-120 11 p.

Research output: Contribution to journalReview article

Amino Acid Motifs
G-Protein-Coupled Receptors
Carrier Proteins
Proteins
Endoplasmic Reticulum
1 Citation (Scopus)

Specific TBC Domain-Containing Proteins Control the ER-Golgi-Plasma Membrane Trafficking of GPCRs

Wei, Z., Zhang, M., Li, C., Huang, W., Fan, Y., Guo, J., Khater, M., Fukuda, M., Dong, Z., Hu, G. & Wu, G., Jul 9 2019, In : Cell Reports. 28, 2, p. 554-566.e4

Research output: Contribution to journalArticle

Open Access
Cell membranes
G-Protein-Coupled Receptors
Cell Membrane
Proteins
GTPase-Activating Proteins
2 Citations (Scopus)

The GTPase Rab1 is required for NLRP3 inflammasome activation and inflammatory lung injury

Zhang, Y., Wang, L., Lv, Y., Jiang, C., Wu, G., Dull, R. O., Minshall, R. D., Malik, A. B. & Hu, G., Jan 1 2019, In : Journal of Immunology. 202, 1, p. 194-206 13 p.

Research output: Contribution to journalArticle

Inflammasomes
Interleukin-18
GTP Phosphohydrolases
Lung Injury
Interleukin-1
2018
18 Citations (Scopus)

Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells

Liu, J., Livingston, M. J., Dong, G., Tang, C., Su, Y., Wu, G., Yin, X. M. & Dong, Z., Mar 1 2018, In : Cell Death and Disease. 9, 3, 322.

Research output: Contribution to journalArticle

trichostatin A
Histone Deacetylase Inhibitors
Autophagy
Acute Kidney Injury
Cisplatin
12 Citations (Scopus)

RAB26-dependent autophagy protects adherens junctional integrity in acute lung injury

Dong, W., He, B., Qian, H., Liu, Q., Wang, D., Li, J., Wei, Z., Wang, Z., Xu, Z., Wu, G., Qian, G. & Wang, G., Oct 3 2018, In : Autophagy. 14, 10, p. 1677-1692 16 p.

Research output: Contribution to journalArticle

Acute Lung Injury
Adherens Junctions
Autophagy
Endothelial Cells
Lung
2 Citations (Scopus)

Regulation of SAP102 Synaptic Targeting by Phosphorylation

Wei, Z., Wu, G. & Chen, B-S., Aug 1 2018, In : Molecular Neurobiology. 55, 8, p. 6215-6226 12 p.

Research output: Contribution to journalArticle

Synapses
Phosphorylation
Proteins
Glutamate Receptors
Casein Kinase II
6 Citations (Scopus)

Role of Rab GTPases in the export trafficking of G protein-coupled receptors

Wang, G., Wei, Z. & Wu, G., Mar 4 2018, In : Small GTPases. 9, 1-2, p. 130-135 6 p.

Research output: Contribution to journalReview article

rab GTP-Binding Proteins
G-Protein-Coupled Receptors
Cell Surface Receptors
3 Citations (Scopus)
STAT1 Transcription Factor
effectors
ischemia
kidneys
Reperfusion Injury
2017
5 Citations (Scopus)
Bone Morphogenetic Protein 4
Calpain
Pulmonary Artery
Smooth Muscle Myocytes
Collagen
7 Citations (Scopus)

Chlorpyrifos and chlorpyrifos oxon impair the transport of membrane bound organelles in rat cortical axons

Gao, J., Naughton, S. X., Beck, W. D., Hernandez, C. M., Wu, G., Wei, Z., Yang, X., Bartlett, M. G. & Terry, A. V., Sep 1 2017, In : NeuroToxicology. 62, p. 111-123 13 p.

Research output: Contribution to journalArticle

Chlorpyrifos
Organelles
Axons
Rats
Membranes
11 Citations (Scopus)

Epithelial sodium channel-α mediates the protective effect of the TNF-derived TIP peptide in pneumolysin-induced endothelial barrier dysfunction

Czikora, I., Alli, A. A., Sridhar, S., Matthay, M. A., Pillich, H., Hudel, M., Berisha, B., Gorshkov, B. A., Romero Lucas, M. J., Gonzales, J. N., Wu, G., Huo, Y., Su, Y., Verin, A. D., Fulton, D. J., Chakraborty, T., Eaton, D. C. & Lucas, R., Jul 21 2017, In : Frontiers in immunology. 8, JUL, 842.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Endothelial Cells
Acid Sensing Ion Channels
Lung
Peptides
13 Citations (Scopus)

MicroRNA-375 is induced in cisplatin nephrotoxicity to repress hepatocyte nuclear factor 1-β

Hao, J., Lou, Q., Wei, Q., Mei, S., Li, L., Wu, G., Mi, Q. S., Mei, C. & Dong, Z., Mar 17 2017, In : Journal of Biological Chemistry. 292, 11, p. 4571-4582 12 p.

Research output: Contribution to journalArticle

Hepatocyte Nuclear Factor 1
MicroRNAs
Cisplatin
Homeobox Genes
Kidney
12 Citations (Scopus)

The GTPase Rab43 Controls the Anterograde ER-Golgi Trafficking and Sorting of GPCRs

Li, C., Wei, Z., Fan, Y., Huang, W., Su, Y., Li, H., Dong, Z., Fukuda, M., Khater, M. & Wu, G., Oct 24 2017, In : Cell Reports. 21, 4, p. 1089-1101 13 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
G-Protein-Coupled Receptors
Sorting
Endoplasmic Reticulum
Membrane Proteins
2016
14 Citations (Scopus)

ARF1 promotes prostate tumorigenesis via targeting oncogenic MAPK signaling

Davis, J. E., Xie, X., Guo, J., Huang, W., Chu, W. M., Huang, S., Teng, Y. & Wu, G., Jan 1 2016, In : Oncotarget. 7, 26, p. 39834-39845 12 p.

Research output: Contribution to journalArticle

ADP-Ribosylation Factor 1
Mitogen-Activated Protein Kinases
Prostate
Carcinogenesis
Prostatic Neoplasms
12 Citations (Scopus)

GGA3 interacts with a G protein-coupled receptor and modulates its cell surface export

Zhang, M., Davis, J. E., Li, C., Gao, J., Huang, W., Lambert, N. A., Terry, A. V. & Wu, G., Apr 1 2016, In : Molecular and Cellular Biology. 36, 7, p. 1152-1163 12 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
trans-Golgi Network
Vesicular Transport Adaptor Proteins
ADP-Ribosylation Factors
Mitogen-Activated Protein Kinase 3
9 Citations (Scopus)

Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2

Zhang, M., Huang, W., Gao, J., Terry, A. V. & Wu, G., Nov 30 2016, In : Scientific Reports. 6, 37921.

Research output: Contribution to journalArticle

Adrenergic Receptors
G-Protein-Coupled Receptors
Small Interfering RNA
ADP-Ribosylation Factors
Ear
15 Citations (Scopus)

Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1

Xie, X., Tang, S. C., Cai, Y., Pi, W., Deng, L., Wu, G., Chavanieu, A. & Teng, Y., Jan 1 2016, In : Oncotarget. 7, 36, p. 58111-58120 10 p.

Research output: Contribution to journalArticle

ADP-Ribosylation Factor 1
Breast Neoplasms
Neoplasm Metastasis
Zebrafish
Genes
11 Citations (Scopus)

Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression

Du, R. H., Wu, F. F., Lu, M., Shu, X. D., Ding, J. H., Wu, G. & Hu, G., Oct 1 2016, In : Redox Biology. 9, p. 178-187 10 p.

Research output: Contribution to journalArticle

Inflammasomes
Astrocytes
Modulation
Depression
Proteins
2015
7 Citations (Scopus)

A single mutation in helix 8 enhances the angiotensin II type 1a receptor transport and signaling

Zhu, S., Zhang, M., Davis, J. E., Wu, W. H., Surrao, K., Wang, H. & Wu, G., Dec 1 2015, In : Cellular Signalling. 27, 12, p. 2371-2379 9 p.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
Mutation
Coat Protein Complex I
Transport Vesicles
Inositol Phosphates
27 Citations (Scopus)

BRET evidence that β2 adrenergic receptors do not oligomerize in cells

Lan, T. H., Liu, Q., Li, C., Wu, G., Steyaert, J. & Lambert, N. A., May 8 2015, In : Scientific Reports. 5, 10166.

Research output: Contribution to journalArticle

Energy Transfer
Adrenergic Receptors
Membrane Proteins
G-Protein-Coupled Receptors
Protein Subunits
5 Citations (Scopus)

Lateral diffusion contributes to FRET from lanthanide-tagged membrane proteins

Lan, T. H., Wu, G. & Lambert, N. A., Jul 20 2015, In : Biochemical and Biophysical Research Communications. 464, 1, p. 244-248 5 p.

Research output: Contribution to journalArticle

Lanthanoid Series Elements
Energy Transfer
Energy transfer
Membrane Proteins
Excited states

Preface

Wu, G., 2015, In : Progress in Molecular Biology and Translational Science. 132, p. xiii

Research output: Contribution to journalEditorial

20 Citations (Scopus)

Rab5-mediated VE-cadherin internalization regulates the barrier function of the lung microvascular endothelium

Yang, J., Yao, W., Qian, G., Wei, Z., Wu, G. & Wang, G., Dec 1 2015, In : Cellular and Molecular Life Sciences. 72, 24, p. 4849-4866 18 p.

Research output: Contribution to journalArticle

Endothelium
Lipopolysaccharides
Lung
Cell Polarity
Endothelial Cells
1 Citation (Scopus)

Regulation of α2B-adrenerigc receptor export trafficking by specific motifs

Wu, G., Davis, J. E. & Zhang, M., Jan 1 2015, Trafficking of GPCRs, 2015. Wu, G. (ed.). Elsevier B.V., p. 227-244 18 p. (Progress in Molecular Biology and Translational Science; vol. 132).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

G-Protein-Coupled Receptors
Endoplasmic Reticulum
Adrenergic Receptors
Carrier Proteins
Cell Membrane
8 Citations (Scopus)

Regulation of β-adrenergic receptor trafficking and lung microvascular endothelial cell permeability by Rab5 GTPase

Yang, J., Sun, H., Zhang, J., Hu, M., Wang, J., Wu, G. & Wang, G., Jun 1 2015, In : International Journal of Biological Sciences. 11, 8, p. 868-878 11 p.

Research output: Contribution to journalArticle

trafficking
GTP Phosphohydrolases
guanosinetriphosphatase
adrenergic receptors
Adrenergic Receptors
14 Citations (Scopus)

ROS and endothelial nitric oxide synthase (eNOS)-dependent trafficking of angiotensin II type 2 receptor begets neuronal NOS in cardiac myocytes

Jang, J. H., Chun, J. N., Godo, S., Wu, G., Shimokawa, H., Jin, C. Z., Jeon, J. H., Kim, S. J., Jin, Z. H. & Zhang, Y. H., May 1 2015, In : Basic Research in Cardiology. 110, 3

Research output: Contribution to journalArticle

Angiotensin Type 2 Receptor
Nitric Oxide Synthase Type III
Cardiac Myocytes
Angiotensin II
Up-Regulation
6 Citations (Scopus)

The mechanism and function of mitogen-activated protein kinase activation by ARF1

Zhou, F., Dong, C., Davis, J. E., Wu, W. H., Surrao, K. & Wu, G., Oct 1 2015, In : Cellular Signalling. 27, 10, p. 2035-2044 10 p.

Research output: Contribution to journalArticle

ADP-Ribosylation Factor 1
Mitogen-Activated Protein Kinases
Ribosomal Protein S6 Kinases
Cell Proliferation
Monomeric GTP-Binding Proteins

Trafficking of GPCRs. Preface

Wu, G., Jan 1 2015, In : Progress in molecular biology and translational science. 132, p. xiii

Research output: Contribution to journalEditorial

Biological Models
Amino Acid Motifs
Protein Transport
G-Protein-Coupled Receptors
Cell Membrane
2014
15 Citations (Scopus)

Anterograde trafficking of KCa3.1 in polarized epithelia is Rab1- And Rab8-Dependent and recycling endosome-independent

Bertuccio, C. A., Lee, S. L., Wu, G., Butterworth, M. B., Hamilton, K. L. & Devor, D. C., Mar 14 2014, In : PloS one. 9, 3, e92013.

Research output: Contribution to journalArticle

endosomes
Endosomes
recycling
Recycling
epithelium
18 Citations (Scopus)

Endothelin-1/Endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis

Teoh, J. P., Park, K. M., Wang, Y., Hu, Q., Kim, S., Wu, G., Huang, S., Maihle, N. J. & Kim, I., Sep 3 2014, In : Cellular Signalling. 26, 12, p. 2885-2895 11 p.

Research output: Contribution to journalArticle

Endothelin A Receptors
Endothelin-1
Ovarian Neoplasms
Carcinogenesis
Arrestin
2013
5 Citations (Scopus)

G-protein-coupled receptor interaction with small GTPases

Dong, C. & Wu, G., 2013, G Protein Coupled ReceptorsModeling, Activation, Interactions and Virtual Screening. Academic Press Inc., p. 97-108 12 p. (Methods in Enzymology; vol. 522).

Research output: Chapter in Book/Report/Conference proceedingChapter

Monomeric GTP-Binding Proteins
G-Protein-Coupled Receptors
rab GTP-Binding Proteins
Heterotrimeric GTP-Binding Proteins
Proteins
3 Citations (Scopus)

Identification of endoplasmic reticulum export motifs for G protein-coupled receptors

Wu, G., 2013, G Protein Coupled ReceptorsTrafficking and Oligomerization. Academic Press Inc., p. 189-202 14 p. (Methods in Enzymology; vol. 521).

Research output: Chapter in Book/Report/Conference proceedingChapter

G-Protein-Coupled Receptors
Endoplasmic Reticulum
Adrenergic Receptors
Capsid Proteins
Glycoproteins
6 Citations (Scopus)

The Angiotensin II Type 1 Receptor C-Terminal Lys Residues Interact with Tubulin and Modulate Receptor Export Trafficking

Zhang, X., Wang, H., Duvernay, M. T., Zhu, S. & Wu, G., Feb 25 2013, In : PloS one. 8, 2, e57805.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
angiotensin II
Tubulin
tubulin
receptors
2012
5 Citations (Scopus)

A Single Lys Residue on the First Intracellular Loop Modulates the Endoplasmic Reticulum Export and Cell-Surface Expression of α2A-Adrenergic Receptor

Fan, Y., Li, C., Guo, J., Hu, G. & Wu, G., Dec 5 2012, In : PloS one. 7, 12, e50416.

Research output: Contribution to journalArticle

adrenergic receptors
Endoplasmic Reticulum
endoplasmic reticulum
Adrenergic Receptors
G-Protein-Coupled Receptors
39 Citations (Scopus)

A Triple Arg Motif Mediates α 2B-Adrenergic Receptor Interaction with Sec24C/D and Export

Dong, C., Nichols, C. D., Guo, J., Huang, W., Lambert, N. A. & Wu, G., Jun 1 2012, In : Traffic. 13, 6, p. 857-868 12 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Adrenergic Receptors
Capsid Proteins
G-Protein-Coupled Receptors
Machinery
23 Citations (Scopus)

Rab26 modulates the cell surface transport of α2- adrenergic receptors from the Golgi

Li, C., Fan, Y., Lan, T. H., Lambert, N. A. & Wu, G., Dec 14 2012, In : Journal of Biological Chemistry. 287, 51, p. 42784-42794 11 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Adrenergic Receptors
Small Interfering RNA
Membrane Proteins
Protein Transport
4 Citations (Scopus)

Regulation of post-Golgi traffic of G protein-coupled receptors.

Wu, G., Jan 1 2012, In : Sub-Cellular Biochemistry. 63, p. 83-95 13 p.

Research output: Contribution to journalReview article

G-Protein-Coupled Receptors
Cell Surface Receptors
Cell membranes
Sorting
Endoplasmic Reticulum
39 Citations (Scopus)

Sensitive and High Resolution Localization and Tracking of Membrane Proteins in Live Cells with BRET

Lan, T. H., Liu, Q., Li, C., Wu, G. & Lambert, N. A., Nov 1 2012, In : Traffic. 13, 11, p. 1450-1456 7 p.

Research output: Contribution to journalArticle

Bioluminescence
Energy Transfer
Energy transfer
Membrane Proteins
Design of experiments
39 Citations (Scopus)

Small GTPase regulation of GPCR anterograde trafficking

Wang, G. & Wu, G., Jan 1 2012, In : Trends in Pharmacological Sciences. 33, 1, p. 28-34 7 p.

Research output: Contribution to journalReview article

Monomeric GTP-Binding Proteins
G-Protein-Coupled Receptors
Endoplasmic Reticulum
Heterotrimeric GTP-Binding Proteins
ras Proteins
2011
2 Citations (Scopus)

Anterograde Trafficking of Nascent α2B-Adrenergic Receptor: Structural Basis, Roles of Small GTPases

Dong, C. & Wu, G., Jul 4 2011, In : Current Topics in Membranes. 67, p. 79-100 22 p.

Research output: Contribution to journalArticle

Adrenergic alpha-2 Receptors
Biological Models
Monomeric GTP-Binding Proteins
Dimerization
Golgi Apparatus
31 Citations (Scopus)

Di-acidic motifs in the membrane-distal C termini modulate the transport of angiotensin II receptors from the endoplasmic reticulum to the cell surface

Zhang, X., Dong, C., Wu, Q. J., Balch, W. E. & Wu, G., Jun 10 2011, In : Journal of Biological Chemistry. 286, 23, p. 20525-20535 11 p.

Research output: Contribution to journalArticle

Angiotensin Receptors
Endoplasmic Reticulum
G-Protein-Coupled Receptors
Membranes
Cell membranes

Discovering G protein-coupled receptor motifs mediating export from the endoplasmic reticulum

Dong, C. & Wu, G., Aug 4 2011, Methods for the Discovery and Characterization of G Protein-Coupled Receptors. Stevens, C. W. (ed.). p. 153-166 14 p. (Neuromethods; vol. 60).

Research output: Chapter in Book/Report/Conference proceedingChapter

G-Protein-Coupled Receptors
Endoplasmic Reticulum
Biosynthesis
Cell membranes
Adrenergic Receptors
83 Citations (Scopus)

Inactive-state preassembly of Gq-coupled receptors and G q heterotrimers

Qin, K., Dong, C., Wu, G. & Lambert, N. A., Oct 2011, In : Nature Chemical Biology. 7, 10, p. 740-747 8 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
GTP-Binding Proteins
Gq-G11 GTP-Binding Protein alpha Subunits
Heterotrimeric GTP-Binding Proteins
Muscarinic Receptors
18 Citations (Scopus)

Rab1 GTPase regulates phenotypic modulation of pulmonary artery smooth muscle cells by mediating the transport of angiotensin II type 1 receptor under hypoxia

Yin, H., Li, Q., Qian, G., Wang, Y., Li, Y., Wu, G. & Wang, G., Mar 1 2011, In : International Journal of Biochemistry and Cell Biology. 43, 3, p. 401-408 8 p.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
GTP Phosphohydrolases
Pulmonary Artery
Smooth Muscle Myocytes
Muscle
18 Citations (Scopus)

Regulation of α 2B-adrenergic receptor-mediated extracellular signal-regulated kinase 1/2 (ERK1/2) activation by ADP-ribosylation factor 1

Dong, C., Li, C. & Wu, G., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43361-43369 9 p.

Research output: Contribution to journalArticle

ADP-Ribosylation Factor 1
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Adrenergic Receptors
Chemical activation
30 Citations (Scopus)

α2B-Adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface

Duvernay, M. T., Wang, H., Dong, C., Guidry, J. J., Sackett, D. L. & Wu, G., Apr 22 2011, In : Journal of Biological Chemistry. 286, 16, p. 14080-14089 10 p.

Research output: Contribution to journalArticle

Tubulin
Endoplasmic Reticulum
Adrenergic Receptors
G-Protein-Coupled Receptors
Glutathione Transferase
2010
38 Citations (Scopus)

Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia

Wang, G., Zhang, Z., Xu, Z., Yin, H., Bai, L., Ma, Z., DeCoster, M. A., Qian, G. & Wu, G., Dec 1 2010, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1803, 12, p. 1359-1367 9 p.

Research output: Contribution to journalArticle

Smooth Muscle Myocytes
Cell Proliferation
Lung
Hypoxia-Inducible Factor 1
Cell Hypoxia
29 Citations (Scopus)

ADP-ribosylation factors modulate the cell surface transport of G protein-coupled receptors

Dong, C., Zhang, X., Zhou, F., Dou, H., Duvernay, M. T., Zhang, P. & Wu, G., Apr 1 2010, In : Journal of Pharmacology and Experimental Therapeutics. 333, 1, p. 174-183 10 p.

Research output: Contribution to journalArticle

ADP-Ribosylation Factors
G-Protein-Coupled Receptors
Adrenergic Receptors
Carrier Proteins
Membrane Proteins