• 3416 Citations
  • 36 h-Index
1989 …2019
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Research Output 1989 2019

2019
6 Citations (Scopus)

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

Wright, S. C., Kozielewicz, P., Kowalski-Jahn, M., Petersen, J., Bowin, C. F., Slodkowicz, G., Marti-Solano, M., Rodríguez, D., Hot, B., Okashah, N., Strakova, K., Valnohova, J., Babu, M. M., Lambert, N. A., Carlsson, J. & Schulte, G., Dec 1 2019, In : Nature Communications. 10, 1, 667.

Research output: Contribution to journalArticle

Open Access
Drug Receptors
Metagenomics
Basic Amino Acids
Phosphoproteins
Energy Transfer
3 Citations (Scopus)

The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2

Wang, J., Zhao, J., Cui, X., Mysona, B. A., Navneet, S., Saul, A., Ahuja, M., Lambert, N., Gazaryan, I. G., Thomas, B., Bollinger, K. E. & Smith, S. B., Apr 2019, In : Free Radical Biology and Medicine. 134, p. 604-616 13 p.

Research output: Contribution to journalArticle

Retinal Cone Photoreceptor Cells
Molecular Chaperones
Cones
Modulation
Antioxidant Response Elements
2 Citations (Scopus)

Variable G protein determinants of GPCR coupling selectivity

Okashah, N., Wan, Q., Ghosh, S., Sandhu, M., Inoue, A., Vaidehi, N. & Lambert, N. A., Jun 11 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 24, p. 12054-12059 6 p.

Research output: Contribution to journalArticle

Open Access
G-Protein-Coupled Receptors
GTP-Binding Proteins
Heterotrimeric GTP-Binding Proteins
Energy Transfer
Nucleotides
2018
19 Citations (Scopus)

Mini G protein probes for active G protein– coupled receptors (GPCRs) in live cells

Wan, Q., Okashah, N., Inoue, A., Nehme, R., Carpenter, B., Tate, C. G. & Lambert, N. A., Jan 1 2018, In : Journal of Biological Chemistry. 293, 19, p. 7466-7473 8 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
GTP-Binding Proteins
Chemical activation
Bioluminescence
Assays
2017

Extreme vetting of dopamine receptor oligomerization

Asher, W. B., Mathiasen, S., Holsey, M. D., Grinnell, S. G., Lambert, N. A. & Javitch, J. A., Jan 1 2017, Receptors. Humana Press Inc., p. 99-127 29 p. (Receptors; vol. 33).

Research output: Chapter in Book/Report/Conference proceedingChapter

Dopamine Receptors
Uncertainty
Therapeutics
2016
7 Citations (Scopus)

Activated G protein Gαs samples multiple endomembrane compartments

Martin, B. R. & Lambert, N. A., Sep 23 2016, In : Journal of Biological Chemistry. 291, 39, p. 20295-20302 8 p.

Research output: Contribution to journalArticle

Cell membranes
GTP-Binding Proteins
Cell Membrane
Chemical activation
Bioluminescence
12 Citations (Scopus)

GGA3 interacts with a G protein-coupled receptor and modulates its cell surface export

Zhang, M., Davis, J. E., Li, C., Gao, J., Huang, W., Lambert, N. A., Terry, A. V. & Wu, G., Apr 1 2016, In : Molecular and Cellular Biology. 36, 7, p. 1152-1163 12 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
trans-Golgi Network
Vesicular Transport Adaptor Proteins
ADP-Ribosylation Factors
Mitogen-Activated Protein Kinase 3
35 Citations (Scopus)

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

Halls, M. L., Yeatman, H. R., Nowell, C. J., Thompson, G. L., Gondin, A. B., Civciristov, S., Bunnett, N. W., Lambert, N. A., Poole, D. P. & Canals, M., Feb 9 2016, In : Science Signaling. 9, 414, ra16.

Research output: Contribution to journalArticle

Opioid Receptors
Cell membranes
Cell Membrane
Extracellular Signal-Regulated MAP Kinases
Morphine
3 Citations (Scopus)
Guanosine Triphosphate
GTP-Binding Proteins
GTPase-Activating Proteins
Amino Acid Motifs
RGS Proteins
2015
11 Citations (Scopus)

A high-throughput drug screening strategy for detecting rhodopsin P23H mutant rescue and degradation

Chen, Y., Tang, H., Seibel, W., Papoian, R., Li, X., Lambert, N. A. & Palczewski, K., Jan 1 2015, In : Investigative Ophthalmology and Visual Science. 56, 4, p. 2553-2567 15 p.

Research output: Contribution to journalArticle

Opsins
Preclinical Drug Evaluations
Rhodopsin
Mutant Proteins
Immunoassay
27 Citations (Scopus)

BRET evidence that β2 adrenergic receptors do not oligomerize in cells

Lan, T. H., Liu, Q., Li, C., Wu, G., Steyaert, J. & Lambert, N. A., May 8 2015, In : Scientific Reports. 5, 10166.

Research output: Contribution to journalArticle

Energy Transfer
Adrenergic Receptors
Membrane Proteins
G-Protein-Coupled Receptors
Protein Subunits
5 Citations (Scopus)

Lateral diffusion contributes to FRET from lanthanide-tagged membrane proteins

Lan, T. H., Wu, G. & Lambert, N. A., Jul 20 2015, In : Biochemical and Biophysical Research Communications. 464, 1, p. 244-248 5 p.

Research output: Contribution to journalArticle

Lanthanoid Series Elements
Energy Transfer
Energy transfer
Membrane Proteins
Excited states
17 Citations (Scopus)

Monitoring G protein activation in cells with BRET

Masuho, I., Martemyanov, K. A. & Lambert, N. A., Jan 1 2015, In : Methods in Molecular Biology. 1335, p. 107-113 7 p.

Research output: Contribution to journalArticle

GTP-Binding Proteins
Fluorescence Resonance Energy Transfer
Protein Conformation
Second Messenger Systems
Luminescence
12 Citations (Scopus)

Using Bioluminescence Resonance Energy Transfer (BRET) to Characterize Agonist-Induced Arrestin Recruitment to Modified and Unmodified G Protein-Coupled Receptors

Donthamsetti, P., Quejada, J. R., Javitch, J. A., Gurevich, V. V. & Lambert, N. A., Sep 1 2015, In : Current protocols in pharmacology. 70, 1, p. 2.14.1-2.14.14

Research output: Contribution to journalArticle

Arrestin
Energy Transfer
G-Protein-Coupled Receptors
Ligands
GTP-Binding Proteins
2014
17 Citations (Scopus)

Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking

Yeatman, H. R., Lane, J. R., Choy, K. H. C., Lambert, N. A., Sexton, P. M., Christopoulos, A. & Canals, M., May 30 2014, In : Journal of Biological Chemistry. 289, 22, p. 15856-15866 11 p.

Research output: Contribution to journalArticle

Arrestin
Muscarinic Receptors
Modulators
Modulation
Ligands
55 Citations (Scopus)

CrossTalk opposing view: Weighing the evidence for class A GPCR dimers, the jury is still out

Lambert, N. A. & Javitch, J. A., Jun 15 2014, In : Journal of Physiology. 592, 12, p. 2443-2445 3 p.

Research output: Contribution to journalComment/debate

Protein Multimerization
G-Protein-Coupled Receptors
13 Citations (Scopus)

HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats

Jin, C., Sun, J., Stilphen, C. A., Smith, S. M. E., Ocasio, H., Bermingham, B., Darji, S., Guha, A., Patel, R., Geurts, A. M., Jacob, H. J., Lambert, N. A. & O'Connor, P. M., Sep 2014, In : Hypertension. 64, 3, p. 541-550 10 p.

Research output: Contribution to journalArticle

Inbred Dahl Rats
Superoxides
Extremities
Sodium
Inbred BN Rats
9 Citations (Scopus)

L-2-oxothiazolidine-4-carboxylic acid attenuates oxidative stress and inflammation in retinal pigment epithelium

Promsote, W., Veeranan-Karmegam, R., Ananth, S., Shen, D., Chan, C. C., Lambert, N. A., Ganapathy, V. & Martin, P. M., Jan 7 2014, In : Molecular Vision. 20, p. 73-88 16 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Carboxylic Acids
Oxidative Stress
Retinal Pigments
Inflammation
13 Citations (Scopus)

Mutation of three residues in the third intracellular loop of the dopamine D2 receptor creates an internalization-defective receptor

Clayton, C. C., Donthamsetti, P., Lambert, N. A., Javitch, J. A. & Neve, K. A., Nov 28 2014, In : Journal of Biological Chemistry. 289, 48, p. 33663-33675 13 p.

Research output: Contribution to journalArticle

Arrestin
Dopamine D2 Receptors
Vesicular Transport Adaptor Proteins
Mutation
G-Protein-Coupled Receptor Kinase 2
10 Citations (Scopus)

Rebuttal from Nevin A. Lambert and Jonathan A. Javitch

Lambert, N. A. & Javitch, J. A., Jun 15 2014, In : Journal of Physiology. 592, 12, 1 p.

Research output: Contribution to journalComment/debate

G-Protein-Coupled Receptors
2013
20 Citations (Scopus)

Segregation of family A G protein-coupled receptor protomers in the plasma membrane

Gavalas, A., Lan, T. H., Liu, Q., Corrêa, I. R., Javitch, J. A. & Lambert, N. A., Sep 1 2013, In : Molecular Pharmacology. 84, 3, p. 346-352 7 p.

Research output: Contribution to journalArticle

Protein Subunits
G-Protein-Coupled Receptors
Cell Membrane
Metabotropic Glutamate Receptors
Adrenergic Agents
55 Citations (Scopus)

The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts

Jensen, D. D., Godfrey, C. B., Niklas, C., Canals, M., Kocan, M., Poole, D. P., Murphy, J. E., Alemi, F., Cottrell, G. S., Korbmacher, C., Lambert, N. A., Bunnett, N. W. & Corvera, C. U., Aug 9 2013, In : Journal of Biological Chemistry. 288, 32, p. 22942-22960 19 p.

Research output: Contribution to journalArticle

Arrestins
Endosomes
Cell membranes
Bile Acids and Salts
Digestion
2012
39 Citations (Scopus)

A Triple Arg Motif Mediates α 2B-Adrenergic Receptor Interaction with Sec24C/D and Export

Dong, C., Nichols, C. D., Guo, J., Huang, W., Lambert, N. A. & Wu, G., Jun 1 2012, In : Traffic. 13, 6, p. 857-868 12 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Adrenergic Receptors
Capsid Proteins
G-Protein-Coupled Receptors
Machinery
23 Citations (Scopus)

Rab26 modulates the cell surface transport of α2- adrenergic receptors from the Golgi

Li, C., Fan, Y., Lan, T. H., Lambert, N. A. & Wu, G., Dec 14 2012, In : Journal of Biological Chemistry. 287, 51, p. 42784-42794 11 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Adrenergic Receptors
Small Interfering RNA
Membrane Proteins
Protein Transport
39 Citations (Scopus)

Sensitive and High Resolution Localization and Tracking of Membrane Proteins in Live Cells with BRET

Lan, T. H., Liu, Q., Li, C., Wu, G. & Lambert, N. A., Nov 1 2012, In : Traffic. 13, 11, p. 1450-1456 7 p.

Research output: Contribution to journalArticle

Bioluminescence
Energy Transfer
Energy transfer
Membrane Proteins
Design of experiments
2011
73 Citations (Scopus)

CODA-RET reveals functional selectivity as a result of GPCR heteromerization

Urizar, E., Yano, H., Kolster, R., Galés, C., Lambert, N. & Javitch, J. A., Sep 2011, In : Nature Chemical Biology. 7, 9, p. 624-630 7 p.

Research output: Contribution to journalArticle

Dopamine D2 Receptors
Protein Subunits
G-Protein-Coupled Receptors
Dopamine Agonists
Quinpirole
30 Citations (Scopus)

Effects of chlorpyrifos and chlorpyrifos-oxon on the dynamics and movement of mitochondria in rat cortical neurons

Middlemore-Risher, M. L., Adam, B. L., Lambert, N. A. & Terry, A. V., Nov 1 2011, In : Journal of Pharmacology and Experimental Therapeutics. 339, 2, p. 341-349 9 p.

Research output: Contribution to journalArticle

Chlorpyrifos
Organophosphates
Mitochondria
Neurons
Axons
83 Citations (Scopus)

Inactive-state preassembly of Gq-coupled receptors and G q heterotrimers

Qin, K., Dong, C., Wu, G. & Lambert, N. A., Oct 2011, In : Nature Chemical Biology. 7, 10, p. 740-747 8 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
GTP-Binding Proteins
Gq-G11 GTP-Binding Protein alpha Subunits
Heterotrimeric GTP-Binding Proteins
Muscarinic Receptors
33 Citations (Scopus)

Internalization dissociates β2-adrenergic receptors

Lan, T. H., Kuravi, S. & Lambert, N. A., Mar 3 2011, In : PloS one. 6, 2, e17361.

Research output: Contribution to journalArticle

adrenergic receptors
Bioluminescence
Energy Transfer
Adrenergic Receptors
energy transfer
60 Citations (Scopus)

Making structural sense of dimerization interfaces of delta opioid receptor homodimers

Johnston, J. M., Aburi, M., Provasi, D., Bortolato, A., Urizar, E., Lambert, N. A., Javitch, J. A. & Filizola, M., Mar 15 2011, In : Biochemistry. 50, 10, p. 1682-1690 9 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Dimerization
Dimers
Protein Subunits
Association reactions
2010
93 Citations (Scopus)
Histone Deacetylases
Butyrates
Propionates
Fermentation
Dendritic Cells
52 Citations (Scopus)

GPCR dimers fall apart

Lambert, N. A., Mar 30 2010, In : Science Signaling. 3, 115, p. pe12

Research output: Contribution to journalReview article

G-Protein-Coupled Receptors
Oligomers
Dimers
Protein Subunits
Ligands
5 Citations (Scopus)

Methods to detect cell surface expression and constitutive activity of GPR6

Prasad, B. M., Hollins, B. & Lambert, N. A., 2010, Methods in Enzymology. C ed. Academic Press Inc., p. 179-195 17 p. (Methods in Enzymology; vol. 484, no. C).

Research output: Chapter in Book/Report/Conference proceedingChapter

Assays
Cyclic AMP
Membrane Proteins
Biotinylation
Peptide Hydrolases
50 Citations (Scopus)

Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity

Lambert, N. A., Johnston, C. A., Cappell, S. D., Kuravi, S., Kimple, A. J., Willard, F. S. & Siderovski, D. P., Apr 13 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 15, p. 7066-7071 6 p.

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
GTP Phosphohydrolases
G-Protein-Coupled Receptors
RGS Proteins
Proteins
Energy Transfer
G-Protein-Coupled Receptors
Membrane Proteins
Proteins
GTP-Binding Proteins
30 Citations (Scopus)
Energy Transfer
G-Protein-Coupled Receptors
GTP-Binding Proteins
Membrane Proteins
Heterotrimeric GTP-Binding Proteins
2009
223 Citations (Scopus)

GPFM 09A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon

Thangaraju, M., Cresci, G. A., Liu, K., Ananth, S., Gnanaprakasam, J. P., Browning, D. D., Mellinger, J. D., Smith, S. B., Digby, G. J., Lambert, N. A., Prasad, P. D. & Ganapathy, V., Apr 1 2009, In : Cancer Research. 69, 7, p. 2826-2832 7 p.

Research output: Contribution to journalArticle

Butyrates
G-Protein-Coupled Receptors
Fermentation
Colon
Colonic Neoplasms
80 Citations (Scopus)

Instability of a class A G protein-coupled receptor oligomer interface

Fonseca, J. M. & Lambert, N. A., Jun 1 2009, In : Molecular Pharmacology. 75, 6, p. 1296-1299 4 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Protein Subunits
Immobilization
Venus
Dopamine D2 Receptors
59 Citations (Scopus)

Minireview: GPCR and G proteins: Drug efficacy and activation in live cells

Vilardaga, J. P., Bünemann, M., Feinstein, T. N., Lambert, N. A., Nikolaev, V. O., Engelhardt, S., Lohse, M. J. & Hoffmann, C., May 1 2009, In : Molecular Endocrinology. 23, 5, p. 590-599 10 p.

Research output: Contribution to journalShort survey

GTP-Binding Proteins
Ligands
Fluorescence Resonance Energy Transfer
G-Protein-Coupled Receptors
Physiological Phenomena
57 Citations (Scopus)

The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers

Hollins, B., Kuravi, S., Digby, G. J. & Lambert, N. A., Jun 1 2009, In : Cellular Signalling. 21, 6, p. 1015-1021 7 p.

Research output: Contribution to journalArticle

GTP-Binding Proteins
Proteins
Renilla Luciferases
Venus
Heterotrimeric GTP-Binding Proteins
7 Citations (Scopus)

Uncoupling diffusion and binding in FRAP experiments

Lambert, N. A., Mar 9 2009, In : Nature Methods. 6, 3, 1 p.

Research output: Contribution to journalLetter

Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
CD4 Antigens
Fluorescence microscopy
Membrane Proteins
Experiments
2008
42 Citations (Scopus)

Abundance and stability of complexes containing inactive G protein-coupled receptors and G proteins

Qin, K., Sethi, P. R. & Lambert, N. A., Aug 1 2008, In : FASEB Journal. 22, 8, p. 2920-2927 8 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
G-proteins
GTP-Binding Proteins
Chemical activation
GTP-Binding Protein Regulators

A correction to the review titled: "Dissociation of heterotrimeric G proteins in cells"

Lambert, N. A., Jul 15 2008, In : Science Signaling. 1, 28, er3.

Research output: Contribution to journalComment/debate

Heterotrimeric GTP-Binding Proteins
16 Citations (Scopus)

Activity-dependent regulation of the dopamine transporter is mediated by Ca2+/calmodulin-dependent protein kinase signaling

Padmanabhan, S., Lambert, N. A. & Prasad, B. M., Nov 1 2008, In : European Journal of Neuroscience. 28, 10, p. 2017-2027 11 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinases
Dopamine Plasma Membrane Transport Proteins
Calcium-Calmodulin-Dependent Protein Kinase Type 2
4-Aminopyridine
Tetrodotoxin
33 Citations (Scopus)

A point mutation to Gαi selectively blocks GoLoco motif binding: Direct evidence for Gα·GoLoco complexes in mitotic spindle dynamics

Willard, F. S., Zheng, Z., Guo, J., Digby, G. J., Kimple, A. J., Conley, J. M., Johnston, C. A., Bosch, D., Willard, M. D., Watts, V. J., Lambert, N. A., Ikeda, S. R., Du, Q. & Siderovski, D. P., Dec 26 2008, In : Journal of Biological Chemistry. 283, 52, p. 36698-36710 13 p.

Research output: Contribution to journalArticle

Amino Acid Motifs
Spindle Apparatus
Point Mutation
Proteins
Microtubules
27 Citations (Scopus)

Differential dissociation of G protein heterotrimers

Digby, G. J., Sethi, P. R. & Lambert, N. A., Jul 1 2008, In : Journal of Physiology. 586, 14, p. 3325-3335 11 p.

Research output: Contribution to journalArticle

GTP-Binding Proteins
Inwardly Rectifying Potassium Channel
Heterotrimeric GTP-Binding Proteins
Ion Channels
Protein Isoforms
51 Citations (Scopus)

Dissociation of heterotrimeric G proteins in cells

Lambert, N. A., Jun 24 2008, In : Science Signaling. 1, 25

Research output: Contribution to journalReview article

Heterotrimeric GTP-Binding Proteins
Guanosine Triphosphate
GTP-Binding Proteins
Protein Subunits
Cell Membrane
72 Citations (Scopus)

Three-dimensional neural constructs: A novel platform for neurophysiological investigation

Irons, H. R., Cullen, D. K., Shapiro, N. P., Lambert, N. A., Lee, R. H. & LaPlaca, M. C., Sep 15 2008, In : Journal of Neural Engineering. 5, 3, p. 333-341 9 p.

Research output: Contribution to journalArticle

Neurons
Clamping devices
Tissue
Scaffolds
Nerve Tissue
2007
10 Citations (Scopus)

Active Gαq subunits and M3 acetylcholine receptors promote distinct modes of association of RGS2 with the plasma membrane

Clark, M. A., Sethi, P. R. & Lambert, N. A., Feb 20 2007, In : FEBS Letters. 581, 4, p. 764-770 7 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Cell membranes
RGS Proteins
Cell Membrane
Association reactions