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Research Output 2001 2018

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Article
2018
7 Citations (Scopus)

CB1R-mediated activation of caspase-3 causes epigenetic and neurobehavioral abnormalities in postnatal ethanol-exposed mice

Subbanna, S., Nagre, N. N., Shivakumar, M., Joshi, V., Psychoyos, D., Kutlar, A., Umapathy, N. S. & Basavarajappa, B. S., Feb 20 2018, In : Frontiers in Molecular Neuroscience. 11, 45.

Research output: Contribution to journalArticle

Epigenomics
Caspase 3
Ethanol
Methyl-CpG-Binding Protein 2
Fetal Alcohol Spectrum Disorders
2015
26 Citations (Scopus)
Acetylation
Histones
Ethanol
Cytoskeleton
Memory Disorders
2014
46 Citations (Scopus)

Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice

Subbanna, S., Nagre, N. N., Shivakumar, M., Siddaramappa, U. N., Psychoyos, D. & Basavarajappa, B. S., Jan 31 2014, In : Neuroscience. 258, p. 422-432 11 p.

Research output: Contribution to journalArticle

Acetylation
Histones
Ethanol
Methyl-CpG-Binding Protein 2
Lysine
10 Citations (Scopus)

Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction

Czikora, I., Sridhar, S., Gorshkov, B. A., Alieva, I. B., Kasa, A., Gonzales, J. N., Potapenko, O., Siddaramappa, U. N., Pillich, H., Rick, F. G., Block, N. L., Verin, A. D., Chakraborty, T., Matthay, M. A., Schally, A. V. & Lucas, R., Jan 1 2014, In : Frontiers in Physiology. 5 JUL, 00259.

Research output: Contribution to journalArticle

Bacterial Toxins
Growth Hormone-Releasing Hormone
Cyclic AMP-Dependent Protein Kinases
Lung
Endothelial Cells
2013
20 Citations (Scopus)

Adenosine A1 Receptors Promote Vasa Vasorum Endothelial Cell Barrier Integrity via Gi and Akt-Dependent Actin Cytoskeleton Remodeling

Siddaramappa Umapathy, N., Kaczmarek, E., Fatteh, N., Burns, N., Lucas, R., Stenmark, K. R., Verin, A. D. & Gerasimovskaya, E. V., Apr 16 2013, In : PloS one. 8, 4, e59733.

Research output: Contribution to journalArticle

Vasa Vasorum
Adenosine A1 Receptors
Endothelial cells
adenosine
microfilaments
56 Citations (Scopus)

G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain

Subbanna, S., Shivakumar, M., Siddaramappa, U. N., Saito, M., Mohan, P. S., Kumar, A., Nixon, R. A., Verin, A. D., Psychoyos, D. & Basavarajappa, B. S., Jun 1 2013, In : Neurobiology of Disease. 54, p. 475-485 11 p.

Research output: Contribution to journalArticle

Histones
Methylation
Ethanol
Brain
Lysine
2012
34 Citations (Scopus)

Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema

Lucas, R., Sridhar, S., Rick, F. G., Gorshkov, B. A., Siddaramappa, U. N., Yang, G., Oseghale, A., Verin, A. D., Chakraborty, T., Matthay, M. A., Zemskov, E. A., White, R., Block, N. L. & Schally, A. V., Feb 7 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 6, p. 2084-2089 6 p.

Research output: Contribution to journalArticle

Growth Hormone-Releasing Hormone
Pulmonary Edema
Permeability
Edema
Lung
13 Citations (Scopus)

Molecular characterization of myosin phosphatase in endothelium

Kim, K. M., Csortos, C., Czikora, I., Fulton, D., Umapathy, N. S., Olah, G. & Verin, A. D., Apr 1 2012, In : Journal of Cellular Physiology. 227, 4, p. 1701-1708 8 p.

Research output: Contribution to journalArticle

Myosin-Light-Chain Phosphatase
Myosins
Endothelium
Endothelial cells
Phosphoric Monoester Hydrolases
33 Citations (Scopus)

Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability

Lucas, R., Yang, G., Gorshkov, B. A., Zemskov, E. A., Sridhar, S., Siddaramappa, U. N., Jezierska-Drutel, A., Alieva, I. B., Leustik, M., Hossain, H., Fischer, B., Catravas, J. D., Verin, A. D., Pittet, J. F., Caldwell, R. B., Mitchell, T. J., Cederbaum, S. D., Fulton, D. J., Matthay, M. A., Caldwell, R. W. & 2 others, Romero Lucas, M. J. & Chakraborty, T., Oct 1 2012, In : American journal of respiratory cell and molecular biology. 47, 4, p. 445-453 9 p.

Research output: Contribution to journalArticle

Arginase
Protein Kinase C
Lung
Endothelial cells
Endothelial Cells
10 Citations (Scopus)
Acute Lung Injury
NAD
Lipopolysaccharides
Bronchoalveolar Lavage Fluid
Lung
2011
83 Citations (Scopus)
Arginase
rho-Associated Kinases
p38 Mitogen-Activated Protein Kinases
Angiotensin II
Blood Vessels
12 Citations (Scopus)

P2Y receptors as regulators of lung endothelial barrier integrity

Zemskov, E. A., Lucas, R., Verin, A. D. & Siddaramappa, U. N., Jan 1 2011, In : Journal of Cardiovascular Disease Research. 2, 1, p. 14-22 9 p.

Research output: Contribution to journalArticle

Blood Vessels
Permeability
Lung
Endothelial Cells
Protective Agents
2010
30 Citations (Scopus)
Endothelial cells
Actin Cytoskeleton
NAD
Actins
Endothelial Cells
29 Citations (Scopus)

Molecular mechanisms involved in adenosine-induced endothelial cell barrier enhancement

Siddaramappa, U. N., Fan, Z. H., Zemskov, E. A., Alieva, I. B., Black, S. M. & Verin, A. D., May 1 2010, In : Vascular Pharmacology. 52, 5-6, p. 199-206 8 p.

Research output: Contribution to journalArticle

Adenosine
Endothelial Cells
Electric Impedance
Pulmonary Artery
Small Interfering RNA
22 Citations (Scopus)

Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter

Miyauchi, S., Gopal, E., Babu, E., Srinivas, S. R., Kubo, Y., Siddaramappa, U. N., Thakkar, S. V., Ganapathy, V. & Prasad, P. D., Jun 1 2010, In : Biochimica et Biophysica Acta - Biomembranes. 1798, 6, p. 1164-1171 8 p.

Research output: Contribution to journalArticle

Pyrrolidonecarboxylic Acid
Sodium
Amino Acid Transport Systems
Chemical activation
Oocytes
23 Citations (Scopus)

The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - A crucial role for protein kinase C-α inhibition

Xiong, C., Yang, G., Kumar, S., Aggarwal, S., Leustik, M., Snead, C., Hamacher, J., Fischer, B., Siddaramappa, U. N., Hossain, H., Wendel, A., Catravas, J. D., Verin, A. D., Fulton, D. J., Black, S. M., Chakraborty, T. & Lucas, R., May 1 2010, In : Vascular Pharmacology. 52, 5-6, p. 207-213 7 p.

Research output: Contribution to journalArticle

Lectins
Protein Kinase C
Myosin Light Chains
Endothelial Cells
Lung
2009
16 Citations (Scopus)

Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity

Kumar, S., Sun, X., Wiseman, D. A., Tian, J., Umapathy, N. S., Verin, A. D. & Black, S. M., Mar 1 2009, In : DNA and cell biology. 28, 3, p. 119-129 11 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Hydrogen Peroxide
Transcription Factor AP-1
Hydroxyl Radical
Zinc
33 Citations (Scopus)

The carboxyl-terminal domain of Atypical protein kinase Cζ binds to ceramide and regulates junction formation in Epithelial cells

Wang, G., Krishnamurthy, K., Umapathy, N. S., Verin, A. D. & Bieberich, E., May 22 2009, In : Journal of Biological Chemistry. 284, 21, p. 14469-14475 7 p.

Research output: Contribution to journalArticle

Ceramides
Epithelial Cells
Protein Kinases
Madin Darby Canine Kidney Cells
Electric Impedance
2008
16 Citations (Scopus)

Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells

Umapathy, N. S., Dun, Y., Martin, P. M., Duplantier, J. N., Roon, P., Prasad, P., Smith, S. B. & Ganapathy, V., Nov 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 5151-5160 10 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Glutamine
Ganglia
Neuroglia
In Situ Hybridization
55 Citations (Scopus)

Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy

Karunakaran, S., Siddaramappa, U. N., Thangaraju, M., Hatanaka, T., Itagaki, S., Munn, D. H., Prasad, P. D. & Ganapathy, V., Sep 15 2008, In : Biochemical Journal. 414, 3, p. 343-355 13 p.

Research output: Contribution to journalArticle

Chemotherapy
Tryptophan
Cells
Derivatives
Drug Therapy
2007
50 Citations (Scopus)

Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney

Gopal, E., Siddaramappa, U. N., Martin, P. M., Ananth, S., Gnana-Prakasam, J. P., Becker, H., Wagner, C. A., Ganapathy, V. & Prasad, P. D., Nov 1 2007, In : Biochimica et Biophysica Acta - Biomembranes. 1768, 11, p. 2690-2697 8 p.

Research output: Contribution to journalArticle

Cloning
Niacin
Organism Cloning
Lactic Acid
Monocarboxylic Acid Transporters
43 Citations (Scopus)
Proton-Coupled Folate Transporter
Retina
Organism Cloning
Folic Acid
Xenopus laevis
35 Citations (Scopus)
Amino Acid Transport Systems
Carnitine
Prodrugs
Butyrates
Inflammation
2006
43 Citations (Scopus)

Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3)

Hu, H., Endres, C. J., Chang, C., Umapathy, N. S., Lee, E. W., Fei, Y. J., Itagaki, S., Swaan, P. W., Ganapathy, V. & Unadkat, J. D., May 1 2006, In : Molecular Pharmacology. 69, 5, p. 1542-1553 12 p.

Research output: Contribution to journalArticle

Nucleoside Transport Proteins
Structure-Activity Relationship
gemcitabine
Quantitative Structure-Activity Relationship
Membrane Potentials
20 Citations (Scopus)

Functional Characteristics of NaS2, a Placenta-specific Na+-coupled Transporter for Sulfate and Oxyanions of the Micronutrients Selenium and Chromium

Miyauchi, S., Srinivas, S. R., Fei, Y. J., Gopal, E., Umapathy, N. S., Wang, H., Conway, S. J., Ganapathy, V. & Prasad, P. D., Jun 1 2006, In : Placenta. 27, 6-7, p. 550-559 10 p.

Research output: Contribution to journalArticle

Micronutrients
Chromium
Selenium
Placenta
Sulfates
2005
40 Citations (Scopus)
Glutamine
Protein Isoforms
system N protein 1
Messenger RNA
Substrate Specificity
2004
31 Citations (Scopus)

Induction of cystine-glutamate transporter Xc - by human immunodeficiency virus type 1 transactivator protein Tat in retinal pigment epithelium

Bridges, C. C., Hu, H., Miyauchi, S., Siddaramappa, U. N., Ganapathy, M. E., Ignatowicz, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Sep 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 2906-2914 9 p.

Research output: Contribution to journalArticle

tat Gene Products
Amino Acid Transport System X-AG
Trans-Activators
Cystine
Retinal Pigment Epithelium
45 Citations (Scopus)

Transport of amino acid esters and the amino-acid-based prodrug valganciclovir by the amino acid transporter ATB 0,+

Siddaramappa, U. N., Ganapathy, V. & Ganapathy, M. E., Jul 1 2004, In : Pharmaceutical Research. 21, 7, p. 1303-1310 8 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Prodrugs
Esters
Amino Acids
Induced currents
2001
28 Citations (Scopus)

Novel scintillation proximity assay for measuring membrane-associated steps of peptidoglycan biosynthesis in Escherichia coli

Chandrakala, B., Elias, B. C., Mehra, U., Umapathy, N. S., Dwarakanath, P., Balganesh, T. S. & DeSousa, S. M., Mar 12 2001, In : Antimicrobial Agents and Chemotherapy. 45, 3, p. 768-775 8 p.

Research output: Contribution to journalArticle

Peptidoglycan
Escherichia coli
Membranes
Uridine Diphosphate Sugars
Enzymes