If you made any changes in Pure, your changes will be visible here soon.

Research Output 1989 2019

Filter
Article

Ablation of endothelial Pfkfb3 protects mice from acute lung injury in LPS-induced endotoxemia

Wang, L., Cao, Y., Gorshkov, B., Zhou, Y., Yang, Q., Xu, J., Ma, Q., Zhang, X., Wang, J., Mao, X., Zeng, X., Su, Y., Verin, A. D., Hong, M., Liu, Z. & Huo, Y., Aug 2019, In : Pharmacological Research. 146, 104292.

Research output: Contribution to journalArticle

Endotoxemia
Acute Lung Injury
Lipopolysaccharides
Endothelial Cells
Lung
14 Citations (Scopus)

Activation of calpain-2 by mediators in pulmonary vascular remodeling of pulmonary arterial hypertension

Kovacs, L., Han, W., Rafikov, R., Bagi, Z., Offermanns, S., Saido, T. C., Black, S. M. & Su, Y., Mar 2016, In : American journal of respiratory cell and molecular biology. 54, 3, p. 384-393 10 p.

Research output: Contribution to journalArticle

Calpain
Pulmonary Hypertension
Chemical activation
Lung
Muscle
10 Citations (Scopus)

Activation of calpain by renin-angiotensin system in pleural mesothelial cells mediates tuberculous pleural fibrosis

Yang, J., Xiang, F., Cai, P. C., Lu, Y. Z., Xu, X. X., Yu, F., Li, F. Z., Greer, P. A., Shi, H. Z., Zhou, Q., Xin, J. B., Ye, H., Su, Y. & Ma, W. L., Jul 1 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 311, 1, p. L145-L153

Research output: Contribution to journalArticle

Calpain
Renin-Angiotensin System
Fibrosis
Pleural Effusion
Pleural Tuberculosis
13 Citations (Scopus)

Acute hypoxia increases intracellular L-arginine content in cultured porcine pulmonary artery enclothelial cells

Su, Y. & Block, E. R., May 1996, In : Journal of Cellular Physiology. 167, 2, p. 349-353 5 p.

Research output: Contribution to journalArticle

Pulmonary Artery
Arginine
Swine
Calpain
Endothelial cells
19 Citations (Scopus)

Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function

Toque, H. A., Nunes, K. P., Yao, L., Xu, Z., Kondrikov, D., Su, Y., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Jan 1 2013, In : PloS one. 8, 8, p. e72277

Research output: Contribution to journalArticle

Arginase
arginase
blood vessels
Blood Vessels
Medical problems
233 Citations (Scopus)

Autophagy in proximal tubules protects against acute kidney injury

Jiang, M., Wei, Q., Dong, G., Komatsu, M., Su, Y. & Dong, Z., Dec 2 2012, In : Kidney International. 82, 12, p. 1271-1283 13 p.

Research output: Contribution to journalArticle

Autophagy
Acute Kidney Injury
Cisplatin
Knockout Mice
Kidney
25 Citations (Scopus)

Bleomycin induced epithelial-mesenchymal transition (EMT) in pleural mesothelial cells

Chen, L. J., Ye, H., Zhang, Q., Li, F. Z., Song, L. J., Yang, J., Mu, Q., Rao, S. S., Cai, P. C., Xiang, F., Zhang, J. C., Su, Y., Xin, J. B. & Ma, W. L., Mar 1 2015, In : Toxicology and Applied Pharmacology. 283, 2, p. 75-82 8 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Bleomycin
Idiopathic Pulmonary Fibrosis
Fibrosis
Collagen
5 Citations (Scopus)
Bone Morphogenetic Protein 4
Calpain
Pulmonary Artery
Smooth Muscle Myocytes
Collagen
10 Citations (Scopus)

Calpain-2 activates Akt via TGF-β1-mTORC2 pathway in pulmonary artery smooth muscle cells

Abeyrathna, P., Kovacs, L., Han, W. & Su, Y., Jul 1 2016, In : American Journal of Physiology - Cell Physiology. 311, 1, p. C24-C34

Research output: Contribution to journalArticle

Calpain
Transforming Growth Factors
Platelet-Derived Growth Factor
Pulmonary Artery
Smooth Muscle Myocytes
17 Citations (Scopus)

Calpain 2-dependent IκBα degradation mediates CPT-11 secondary resistance in colorectal cancer xenografts

Fenouille, N., Grosso, S., Su, Y., Didier, M., Pontier-Bres, R., Imbert, V., Czerucka, D., Caroli-Bosc, F. X., Peyron, J. F. & Lagadec, P., May 1 2012, In : Journal of Pathology. 227, 1, p. 118-129 12 p.

Research output: Contribution to journalArticle

irinotecan
Calpain
Heterografts
Colorectal Neoplasms
Annexin A2
62 Citations (Scopus)

Calpain-2 regulation of VEGF-mediated angiogenesis

Su, Y., Cui, Z., Li, Z. & Block, E. R., Jul 1 2006, In : FASEB Journal. 20, 9, p. 1443-1451 9 p.

Research output: Contribution to journalArticle

calpain
Calpain
vascular endothelial growth factors
angiogenesis
Vascular Endothelial Growth Factor A
10 Citations (Scopus)

Calpain-activated mTORC2/Akt pathway mediates airway smooth muscle remodelling in asthma

Rao, S. S., Mu, Q., Zeng, Y., Cai, P. C., Liu, F., Yang, J., Xia, Y., Zhang, Q., Song, L. J., Zhou, L. L., Li, F. Z., Lin, Y. X., Fang, J., Greer, P. A., Shi, H. Z., Ma, W. L., Su, Y. & Ye, H., Feb 1 2017, In : Clinical and Experimental Allergy. 47, 2, p. 176-189 14 p.

Research output: Contribution to journalArticle

Calpain
Smooth Muscle
Asthma
Smooth Muscle Myocytes
Airway Remodeling
68 Citations (Scopus)

Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease

Ma, W., Han, W., Greer, P. A., Tuder, R. M., Toque, H. A., Wang, K. K. W., Caldwell, R. W. & Su, Y., Nov 1 2011, In : Journal of Clinical Investigation. 121, 11, p. 4548-4566 19 p.

Research output: Contribution to journalArticle

Calpain
Pulmonary Hypertension
Rodentia
Lung
Epidermal Growth Factor
4 Citations (Scopus)

CAT-1 as a novel CAM stabilizes endothelial integrity and mediates the protective actions of l-Arg via a NO-independent mechanism

Guo, L., Tian, S., Chen, Y., Mao, Y., Cui, S., Hu, A., Zhang, J., Xia, S. L., Su, Y., Du, J., Block, E. R., Wang, X. L. & Cui, Z., Oct 1 2015, In : Journal of molecular and cellular cardiology. 87, p. 180-191 12 p.

Research output: Contribution to journalArticle

Cationic Amino Acid Transporter 1
Cell Adhesion Molecules
Intercellular Junctions
Basic Amino Acid Transport Systems
Catenins
41 Citations (Scopus)

Caveolin-1 is a negative regulator of NADPH oxidase-derived reactive oxygen species

Chen, F., Barman, S. A., Yu, Y., Haigh, S., Wang, Y., Dou, H., Bagi, Z., Han, W., Su, Y. & Fulton, D. J., Jan 1 2014, In : Free Radical Biology and Medicine. 73, p. 201-213 13 p.

Research output: Contribution to journalArticle

Caveolin 1
NADPH Oxidase
Reactive Oxygen Species
Pulmonary Artery
Pulmonary Hypertension
401 Citations (Scopus)

cGMP mediates the vascular and platelet actions of nitric oxide: Confirmation using an inhibitor of the soluble guanylyl cyclase

Moro, M. A., Russell, R. J., Cellek, S., Lizasoain, I., Su, Y., Darley-Usmar, V. M., Radomski, M. W. & Moncada, S., Feb 20 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 4, p. 1480-1485 6 p.

Research output: Contribution to journalArticle

Blood Vessels
Nitric Oxide
Blood Platelets
Vascular Smooth Muscle
Vasodilator Agents
34 Citations (Scopus)

Chop deficiency protects mice against bleomycin-induced pulmonary fibrosis by attenuating M2 macrophage production

Yao, Y., Wang, Y., Zhang, Z., He, L., Zhu, J., Zhang, M., He, X., Cheng, Z., Ao, Q., Cao, Y., Yang, P., Su, Y., Zhao, J., Zhang, S., Yu, Q., Ning, Q., Xiang, X., Xiong, W., Wang, C. Y. & Xu, Y., May 1 2016, In : Molecular Therapy. 24, 5, p. 915-925 11 p.

Research output: Contribution to journalArticle

Transcription Factor CHOP
Protein Deficiency
Pulmonary Fibrosis
Bleomycin
Macrophages
45 Citations (Scopus)

Cigarette smoke extract inhibits angiogenesis of pulmonary artery endothelial cells: The role of calpain

Su, Y., Cao, W., Han, Z. & Block, E. R., Oct 1 2004, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 287, 4 31-4, p. L794-L800

Research output: Contribution to journalArticle

Calpain
Smoke
Tobacco Products
Pulmonary Artery
Endothelial Cells
12 Citations (Scopus)

Collagen IV contributes to nitric oxide-induced angiogenesis of lung endothelial cells

Wang, H. & Su, Y., May 1 2011, In : American Journal of Physiology - Cell Physiology. 300, 5, p. C979-C988

Research output: Contribution to journalArticle

Nitric Oxide
Collagen
Endothelial Cells
Lung
Integrins
6 Citations (Scopus)

Cotinine concentration in serum correlates with tobacco smoke-induced emphysema in mice

Xu, X., Su, Y. & Fan, Z. H., Jan 27 2014, In : Scientific Reports. 4, 3864.

Research output: Contribution to journalArticle

Cotinine
Emphysema
Smoke
Tobacco
Serum
27 Citations (Scopus)

Crosstalk between calpain activation and TGF-β1 augments collagen-I synthesis in pulmonary fibrosis

Li, F. Z., Cai, P. C., Song, L. J., Zhou, L. L., Zhang, Q., Rao, S. S., Xia, Y., Xiang, F., Xin, J. B., Greer, P. A., Shi, H. Z., Su, Y., Ma, W. L. & Ye, H., Sep 1 2015, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1852, 9, p. 1796-1804 9 p.

Research output: Contribution to journalArticle

Calpain
Pulmonary Fibrosis
Collagen
Lung
Fibroblasts
6 Citations (Scopus)

Dissociation of FK506-binding protein 12.6 kD from ryanodine receptor in bronchial smooth muscle cells in airway hyperresponsiveness in asthma

Du, Y., Zhao, J., Li, X., Jin, S., Ma, W. L., Mu, Q., Xu, S., Yang, J., Rao, S., Zhu, L., Xin, J., Cai, P. C., Su, Y. & Ye, H., Feb 1 2014, In : American journal of respiratory cell and molecular biology. 50, 2, p. 398-408 11 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Ryanodine Receptor Calcium Release Channel
Smooth Muscle Myocytes
Muscle
Asthma
8 Citations (Scopus)
Urethral Obstruction
Proximal Kidney Tubule
Fibrosis
Apoptosis
Kidney
260 Citations (Scopus)

Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells

Su, Y., Han, W., Giraldo, C., De Li, Y. & Block, E. R., Jan 1 1998, In : American journal of respiratory cell and molecular biology. 19, 5, p. 819-825 7 p.

Research output: Contribution to journalArticle

Endothelial cells
Nitric Oxide Synthase
Smoke
Tobacco Products
Pulmonary Artery
1 Citation (Scopus)
Endothelial cells
Half-Life
Endothelial Cells
Aorta
Lung
1 Citation (Scopus)
Endothelial cells
Epoprostenol
Tobacco Products
Pulmonary Artery
Platelet Activating Factor
82 Citations (Scopus)

Endothelial PFKFB3 plays a critical role in angiogenesis

Xu, Y., An, X., Guo, X., Habtetsion, T. G., Wang, Y., Xu, X., Kandala, S., Li, Q., Li, H., Zhang, C., Caldwell, R. B., Fulton, D. J., Su, Y., Hoda, MD. N., Zhou, G., Wu, C. & Huo, Y., Jun 2014, In : Arteriosclerosis, thrombosis, and vascular biology. 34, 6, p. 1231-1239 9 p.

Research output: Contribution to journalArticle

Phosphofructokinase-2
Protein Isoforms
Glycolysis
Endothelial Cells
Lactic Acid
31 Citations (Scopus)

Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase

Sun, X., Kumar, S., Sharma, S., Aggarwal, S., Lu, Q., Gross, C., Rafikova, O., Lee, S. G., Dasarathy, S., Hou, Y., Meadows, M. L., Han, W., Su, Y., Fineman, J. R. & Black, S. M., Jun 2014, In : American journal of respiratory cell and molecular biology. 50, 6, p. 1084-1095 12 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Endothelial cells
Endothelin-1
Pulmonary Hypertension
Endothelial Cells
17 Citations (Scopus)

eNOS-β-actin interaction contributes to increased peroxynitrite formation during hyperoxia in pulmonary artery endothelial cells and mouse lungs

Kondrikov, D., Elms, S., Fulton, D. & Su, Y., Nov 12 2010, In : Journal of Biological Chemistry. 285, 46, p. 35479-35487 9 p.

Research output: Contribution to journalArticle

Hyperoxia
Peroxynitrous Acid
Endothelial cells
Nitric Oxide Synthase
Pulmonary Artery
33 Citations (Scopus)

EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling

Lu, A., Zuo, C., He, Y., Chen, G., Piao, L., Zhang, J., Xiao, B., Shen, Y., Tang, J., Kong, D., Alberti, S., Chen, D., Zuo, S., Zhang, Q., Yan, S., Fei, X., Yuan, F., Zhou, B., Duan, S., Yu, Y. & 5 others, Lazarus, M., Su, Y., Breyer, R. M., Funk, C. D. & Yu, Y., Mar 2 2015, In : Journal of Clinical Investigation. 125, 3, p. 1228-1242 15 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Prostaglandins
Smooth Muscle Myocytes
Pulmonary Artery
Lung
11 Citations (Scopus)

Epithelial sodium channel-α mediates the protective effect of the TNF-derived TIP peptide in pneumolysin-induced endothelial barrier dysfunction

Czikora, I., Alli, A. A., Sridhar, S., Matthay, M. A., Pillich, H., Hudel, M., Berisha, B., Gorshkov, B. A., Romero Lucas, M. J., Gonzales, J. N., Wu, G., Huo, Y., Su, Y., Verin, A. D., Fulton, D. J., Chakraborty, T., Eaton, D. C. & Lucas, R., Jul 21 2017, In : Frontiers in immunology. 8, JUL, 842.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Endothelial Cells
Acid Sensing Ion Channels
Lung
Peptides
2 Citations (Scopus)

Galectin-3 is expressed in vascular smooth muscle cells and promotes pulmonary hypertension through changes in proliferation, apoptosis, and fibrosis

Barman, S. A., Li, X., Haigh, S., Kondrikov, D., Mahboubi, K., Bordan, Z., Stepp, D. W., Zhou, J., Wang, Y., Weintraub, D. S., Traber, P., Snider, W., Jonigk, D., Sullivan, J., Ryan Crislip, G., Butcher, J. T., Thompson, J., Su, Y., Chen, F. & Fulton, D. J. R., May 2019, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 316, 5, p. L784-L797

Research output: Contribution to journalArticle

Galectin 3
Vascular Smooth Muscle
Pulmonary Hypertension
Smooth Muscle Myocytes
Fibrosis
26 Citations (Scopus)

Growth and density-dependent regulation of NO synthase by the actin cytoskeleton in pulmonary artery endothelial cells

Kondrikov, D., Han, H. R., Block, E. R. & Su, Y., Jan 1 2006, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 290, 1, p. L41-L50

Research output: Contribution to journalArticle

Actin Cytoskeleton
Nitric Oxide Synthase
Pulmonary Artery
Actins
Endothelial Cells
7 Citations (Scopus)
Apoptosis Inducing Factor
hyperoxia
Hyperoxia
HSP70 Heat-Shock Proteins
caspases
37 Citations (Scopus)
Rhabdomyolysis
Heme Oxygenase-1
Granulocyte Colony-Stimulating Factor
Acute Kidney Injury
Heme
18 Citations (Scopus)

Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells

Liu, J., Livingston, M. J., Dong, G., Tang, C., Su, Y., Wu, G., Yin, X. M. & Dong, Z., Mar 1 2018, In : Cell Death and Disease. 9, 3, 322.

Research output: Contribution to journalArticle

trichostatin A
Histone Deacetylase Inhibitors
Autophagy
Acute Kidney Injury
Cisplatin
7 Citations (Scopus)

Hsp70 suppresses mitochondrial reactive oxygen species and preserves pulmonary microvascular barrier integrity following exposure to bacterial toxins

Li, X., Yu, Y., Gorshkov, B., Haigh, S., Bordan, Z., Weintraub, D., Rudic, R. D., Chakraborty, T., Barman, S. A., Verin, A. D., Su, Y., Lucas, R., Stepp, D. W., Chen, F. & Fulton, D. J., Jun 12 2018, In : Frontiers in immunology. 9, JUN, 1309.

Research output: Contribution to journalArticle

Bacterial Toxins
geranylgeranylacetone
Reactive Oxygen Species
Lung
Pneumonia
62 Citations (Scopus)

Hydrogen sulfide ameliorates tobacco smoke-induced oxidative stress and emphysema in mice

Han, W., Dong, Z., Dimitropoulou, C. & Su, Y., Oct 15 2011, In : Antioxidants and Redox Signaling. 15, 8, p. 2121-2134 14 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Oxidative stress
Tobacco
Emphysema
Smoke
57 Citations (Scopus)
Acute Kidney Injury
Hyperglycemia
Apoptosis
Kidney
Glucose
35 Citations (Scopus)
citrulline
Citrulline
pulmonary artery
Pulmonary Artery
endothelial cells
8 Citations (Scopus)
Argininosuccinate Synthase
Endotoxins
Endothelial Cells
Lung
Pulmonary Artery
16 Citations (Scopus)

Increasing muscle mass improves vascular function in obese (DB/DB) Mice

Qiu, S., Mintz, J. D., Salet, C. D., Han, W., Giannis, A., Chen, F., Yu, Y., Su, Y., Fulton, D. J. & Stepp, D. W., Jan 1 2014, In : Journal of the American Heart Association. 3, 3, 000854.

Research output: Contribution to journalArticle

Myostatin
Obese Mice
Blood Vessels
Vasodilation
Muscles
23 Citations (Scopus)

Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6

Hao, J., Wei, Q., Mei, S., Li, L., Su, Y., Mei, C. & Dong, Z., Jan 1 2017, In : Kidney International. 91, 1, p. 106-118 13 p.

Research output: Contribution to journalArticle

Death Domain Receptors
Reperfusion Injury
MicroRNAs
Kidney
Acute Kidney Injury
1 Citation (Scopus)

Inhibition of angiotensin II and calpain attenuates pleural fibrosis

Song, L. J., Xiang, F., Ye, H., Huang, H., Yang, J., Yu, F., Xiong, L., Xu, J. J., Greer, P. A., Shi, H. Z., Xin, J. B., Su, Y. & Ma, W. L., Feb 2018, In : Pulmonary Pharmacology and Therapeutics. 48, p. 46-52 7 p.

Research output: Contribution to journalArticle

Calpain
Angiotensin II
Fibrosis
Bleomycin
Losartan
10 Citations (Scopus)

Involvement of calpain-calpastatin in cigarette smoke-induced inhibition of lung endothelial nitric oxide synthase

Cui, Z., Han, Z., Li, Z., Hu, H., Patel, J. M., Antony, V., Block, E. R. & Su, Y., Nov 1 2005, In : American journal of respiratory cell and molecular biology. 33, 5, p. 513-520 8 p.

Research output: Contribution to journalArticle

Calpain
Nitric Oxide Synthase Type III
Smoke
Tobacco Products
Lung
22 Citations (Scopus)

miR-18a-5p Inhibits Sub-pleural Pulmonary Fibrosis by Targeting TGF-β Receptor II

Zhang, Q., Ye, H., Xiang, F., Song, L. J., Zhou, L. L., Cai, P. C., Zhang, J. C., Yu, F., Shi, H. Z., Su, Y., Xin, J. B. & Ma, W. L., Mar 1 2017, In : Molecular Therapy. 25, 3, p. 728-738 11 p.

Research output: Contribution to journalArticle

Pulmonary Fibrosis
Bleomycin
Idiopathic Pulmonary Fibrosis
Epithelial-Mesenchymal Transition
Growth Factor Receptors
70 Citations (Scopus)

Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP)

Wang, C. Y., Shi, J. D., Yang, P., Kumar, P. G., Li, Q. Z., Run, Q. G., Su, Y., Scott, H. S., Kao, K. J. & She, J-X., Mar 13 2003, In : Gene. 306, 1-2, p. 37-44 8 p.

Research output: Contribution to journalArticle

Molecular Cloning
Amino Acids
Genes
Complementary DNA
Proteins
65 Citations (Scopus)

NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling

Barman, S. A., Chen, F., Su, Y., Dimitropoulou, C., Wang, Y., Catravas, J. D., Han, W., Orfi, L., Szantai-Kis, C., Keri, G., Szabadkai, I., Barabutis, N., Rafikova, O., Rafikov, R., Black, S. M., Jonigk, D., Giannis, A., Asmis, R., Stepp, D. W., Ramesh, G. & 1 others, Fulton, D. J., Aug 2014, In : Arteriosclerosis, thrombosis, and vascular biology. 34, 8, p. 1704-1715 12 p.

Research output: Contribution to journalArticle

Adventitia
NADPH Oxidase
Pulmonary Artery
Pulmonary Hypertension
Fibroblasts
7 Citations (Scopus)

Novel peptide for attenuation of hyperoxia-induced disruption of lung endothelial barrier and pulmonary edema via modulating peroxynitrite formation

Kondrikov, D., Gross, C., Black, S. M. & Su, Y., Nov 28 2014, In : Journal of Biological Chemistry. 289, 48, p. 33355-33363 9 p.

Research output: Contribution to journalArticle

Hyperoxia
Peroxynitrous Acid
Pulmonary Edema
Apoptosis
Actins
4 Citations (Scopus)

PFKFB3 in smooth muscle promotes vascular remodeling in pulmonary arterial hypertension

Kovacs, L., Cao, Y., Han, W., Meadows, L., Kovacs-Kasa, A., Kondrikov, D., Verin, A. D., Barman, S. A., Dong, Z., Huo, Y. & Su, Y., Sep 1 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 5, p. 617-627 11 p.

Research output: Contribution to journalArticle

Phosphofructokinase-2
Pulmonary Hypertension
Smooth Muscle
Phosphotransferases
Pulmonary Artery