High dietary calcium reduces body fat content, digestibility of fat, and serum vitamin D in rats

Emilia Papakonstantinou, William P. Flatt, Peter J. Huth, Ruth Babette Harris

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Objective: This study investigated which aspect of energy balance was responsible for the decrease in body fat content of rats fed a high-calcium, high-dairy protein diet. Research Methods and Procedures: Male Wistar rats were fed a control diet (25% kcal fat, 14% kcal protein from casein, 0.4% by weight calcium) or high-calcium diet (25% kcal fat, 7% kcal protein from nonfat dry milk, 7% kcal protein from casein, 2.4% calcium) for 85 days. Body weights, digestible energy intakes, energy expenditures, rectal temperatures, body composition, and serum glucose, insulin, free fatty acids, triglycerides, and 1,25-dihydroxy-vitamin D were measured. Results: Rats fed high-calcium diet gained significantly less weight than controls and had 29% less carcass fat. Gross energy intake was not significantly different between groups, but digestible energy was 90% of gross energy in the high-calcium diet compared with 94% in the control diet because of increased fecal excretion of dietary lipid. The difference in digestible energy intake accounted for differences in carcass energy. Body temperatures and energy expenditures of the rats were not different. The high-calcium diet reduced serum triglycerides by 23% and serum 1,25-dihydroxyvitamin D by 86%. Discussion: These results confirm that a high-calcium diet decreases body weight and fat content due to a lower digestible energy intake caused by increased fecal lipid and a nonsignificant reduction in gross energy intake.

Original languageEnglish (US)
Pages (from-to)387-394
Number of pages8
JournalObesity Research
Volume11
Issue number3
DOIs
StatePublished - Jan 1 2003

Fingerprint

Dietary Calcium
vitamin D
Vitamin D
body fat
Adipose Tissue
digestibility
Fats
lipid content
Diet
Calcium
calcium
Energy Intake
rats
digestible energy
energy intake
lipids
Serum
diet
Caseins
energy expenditure

Keywords

  • Digestible energy
  • Fecal fat
  • Vitamin D

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Public Health, Environmental and Occupational Health

Cite this

High dietary calcium reduces body fat content, digestibility of fat, and serum vitamin D in rats. / Papakonstantinou, Emilia; Flatt, William P.; Huth, Peter J.; Harris, Ruth Babette.

In: Obesity Research, Vol. 11, No. 3, 01.01.2003, p. 387-394.

Research output: Contribution to journalArticle

Papakonstantinou, Emilia ; Flatt, William P. ; Huth, Peter J. ; Harris, Ruth Babette. / High dietary calcium reduces body fat content, digestibility of fat, and serum vitamin D in rats. In: Obesity Research. 2003 ; Vol. 11, No. 3. pp. 387-394.
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