Paul M O'Connor

Associate Professor

  • 1578 Citations
  • 23 h-Index
20042020

Research output per year

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Research Output

2020
Open Access
2019

A basic solution to activate the cholinergic anti-inflammatory pathway via the mesothelium?

Mannon, E. C., Sun, J., Wilson, K., Brands, M., Martinez-Quinones, P., Baban, B. & O'Connor, P. M., Mar 2019, In : Pharmacological Research. 141, p. 236-248 13 p.

Research output: Contribution to journalReview article

Open Access

Ischemic Renal Injury: Can Renal Anatomy and Associated Vascular Congestion Explain Why the Medulla and Not the Cortex Is Where the Trouble Starts?

Ray, S. C., Mason, J. & O'Connor, P. M., Nov 2019, In : Seminars in Nephrology. 39, 6, p. 520-529 10 p.

Research output: Contribution to journalReview article

1 Scopus citations

Necrosis contributes to the development of hypertension in male, but not female, spontaneously hypertensive rats

Abdelbary, M., Rafikova, O., Gillis, E. E., Musall, J. B., Baban, B., O'Connor, P. M., Brands, M. W. & Sullivan, J. C., Dec 1 2019, In : Hypertension. 74, 6, p. 1524-1531 8 p.

Research output: Contribution to journalArticle

Neurovascular protection in voltage-gated proton channel Hv1 knock-out rats after ischemic stroke: interaction with Na+/H+ exchanger-1 antagonism

Li, W., Ward, R., Dong, G., Ergul, A. & O'Connor, P., Jul 2019, In : Physiological reports. 7, 13, e14142.

Research output: Contribution to journalArticle

Open Access

The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

Madaio, M. P., Czikora, I., Kvirkvelia, N., McMenamin, M., Yue, Q., Liu, T., Flores Toque, H. A., Sridhar, S., Covington, K., Alaisami, R., O'Connor, P. M., Caldwell, R. W., Chen, J., Clauss, M., Brands, M. W., Eaton, D. C., Romero Lucas, M. J. & Lucas, R., Jun 2019, In : Kidney International. 95, 6, p. 1359-1372 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Voltage gated proton channels modulate mitochondrial reactive oxygen species production by complex I in renal medullary thick ascending limb

Patel, B., Zheleznova, N. N., Ray, S. C., Sun, J., Cowley, A. W. & O'Connor, P. M., Oct 2019, In : Redox Biology. 27, 101191.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Identification of novel macropinocytosis inhibitors using a rational screen of Food and Drug Administration-approved drugs

Lin, H. P., Singla, B., Ghoshal, P., Faulkner, J. L., Cherian-Shaw, M., O'Connor, P. M., She, J. X., Belin de Chantemele, E. J. & Csányi, G., Sep 2018, In : British Journal of Pharmacology. 175, 18, p. 3640-3655 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

Kidney-targeted inhibition of protein kinase C-α ameliorates nephrotoxic nephritis with restoration of mitochondrial dysfunction

Kvirkvelia, N., McMenamin, M., Warren, M., Jadeja, R. N., Kodeboyina, S. K., Sharma, A., Zhi, W., O'Connor, P. M., Raju, R., Lucas, R. & Madaio, M. P., Aug 2018, In : Kidney International. 94, 2, p. 280-291 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Oral NaHCO 3 activates a splenic anti-inflammatory pathway: Evidence that cholinergic signals are transmitted via mesothelial cells

Ray, S. C., Baban, B., Tucker, M. A., Seaton, A. J., Chang, K. C., Mannon, E. C., Sun, J., Patel, B., Wilson, K., Musall, J. B., Ocasio, H., Irsik, D., Filosa, J. A., Sullivan, J. C., Marshall, B., Harris, R. A. & O’Connor, P. M., May 15 2018, In : Journal of Immunology. 200, 10, p. 3568-3586 19 p.

Research output: Contribution to journalArticle

6 Scopus citations

Sodium bicarbonate loading limits tubular cast formation independent of glomerular injury and proteinuria in Dahl salt-sensitive rats

Ray, S. C., Patel, B., Irsik, D. L., Sun, J., Ocasio, H., Crislip, G. R., Jin, C. H., Chen, J. K., Baban, B., Polichnowski, A. J. & O’Connor, P. M., Jun 1 2018, In : Clinical Science. 132, 11, p. 1179-1197 19 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Developmental Exposure to Endocrine Disruptors Expands Murine Myometrial Stem Cell Compartment as a Prerequisite to Leiomyoma Tumorigenesis

Mas, A., Stone, L., O’Connor, P. M., Yang, Q., Kleven, D., Simon, C., Walker, C. L. & Al-Hendy, A., Mar 1 2017, In : Stem Cells. 35, 3, p. 666-678 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
4 Scopus citations
2016

Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species

Brett Heimlich, J., Speed, J. S., O'Connor, P. M., Pollock, J. S., Townes, T. M., Meiler, S. E., Kutlar, A. & Pollock, D. M., Jan 1 2016, In : British Journal of Pharmacology. 173, 2, p. 386-395 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Proton channels and renal hypertensive injury: A key piece of the Dahl salt-sensitive rat puzzle?

O’Connor, P. M., Guha, A., Stilphen, C. A., Sun, J. & Jin, C., Apr 2016, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 310, 8, p. R679-R690

Research output: Contribution to journalReview article

5 Scopus citations

Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin

Farsijani, N. M., Liu, Q., Kobayashi, H., Davidoff, O., Sha, F., Fandrey, J., Ikizler, T. A., O'Connor, P. M. & Haase, V. H., Apr 1 2016, In : Journal of Clinical Investigation. 126, 4, p. 1425-1437 13 p.

Research output: Contribution to journalArticle

24 Scopus citations
2015

Chronic ANG II infusion induces sex-specific increases in renal T cells in Sprague-Dawley rats

Zimmerman, M. A., Baban, B., Tipton, A. J., O’Connor, P. M. & Sullivan, J. C., Jan 1 2015, In : American Journal of Physiology - Renal Physiology. 308, 7, p. F706-F712

Research output: Contribution to journalArticle

21 Scopus citations

ET-1 increases reactive oxygen species following hypoxia and high-salt diet in the mouse glomerulus

Heimlich, J. B., Speed, J. S., Bloom, C. J., O'Connor, P. M., Pollock, J. S. & Pollock, D. M., Mar 1 2015, In : Acta Physiologica. 213, 3, p. 722-730 9 p.

Research output: Contribution to journalEditorial

24 Scopus citations

Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension

Cowley, A. W., Abe, M., Mori, T., O’Connor, P. M., Ohsaki, Y. & Zheleznova, N. N., 2015, In : American Journal of Physiology - Renal Physiology. 308, 3, p. F179-F197

Research output: Contribution to journalArticle

54 Scopus citations
2014

A radical approach to balancing the tides of tubular flow

O'connor, P. M., Oct 15 2014, In : American Journal of Physiology - Renal Physiology. 307, 8, p. F917-F918

Research output: Contribution to journalEditorial

2 Scopus citations

Basal renal O2 consumption and the efficiency of O2 utilization for Na+ reabsorption

Evans, R. G., Harrop, G. K., Ngo, J. P., Ow, C. P. C. & O'Connor, P. M., Mar 1 2014, In : American Journal of Physiology - Renal Physiology. 306, 5, p. F551-F560

Research output: Contribution to journalArticle

33 Scopus citations

Blood flow, oxygenation, and oxidative stress in the post-stenotic kidney

Evans, R. G. & O'Connor, P. M., Dec 1 2014, Renal Vascular Disease. Springer-Verlag London Ltd, Vol. 9781447128106. p. 151-171 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

High-salt diet blunts renal autoregulation by a reactive oxygen species-dependent mechanism

Fellner, R. C., Cook, A. K., O'Connor, P. M., Zhang, S., Pollock, D. M. & Inscho, E. W., Jul 1 2014, In : American Journal of Physiology - Renal Physiology. 307, 1, p. F33-F40

Research output: Contribution to journalArticle

29 Scopus citations

HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats

Jin, C., Sun, J., Stilphen, C. A., Smith, S. M. E., Ocasio, H., Bermingham, B., Darji, S., Guha, A., Patel, R., Geurts, A. M., Jacob, H. J., Lambert, N. A. & O'Connor, P. M., Sep 2014, In : Hypertension. 64, 3, p. 541-550 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Deficiency of renal cortical EGF increases ENaC activity and contributes to salt-sensitive hypertension

Pavlov, T. S., Levchenko, V., O'Connor, P. M., Ilatovskaya, D. V., Palygin, O., Mori, T., Mattson, D. L., Sorokin, A., Lombard, J. H., Cowley, A. W. & Staruschenko, A., Jun 28 2013, In : Journal of the American Society of Nephrology. 24, 7, p. 1053-1062 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Haemodynamic influences on kidney oxygenation: Clinical implications of integrative physiology

Evans, R. G., Ince, C., Joles, J. A., Smith, D. W., May, C. N., O'Connor, P. M. & Gardiner, B. S., Feb 1 2013, In : Clinical and Experimental Pharmacology and Physiology. 40, 2, p. 106-122 17 p.

Research output: Contribution to journalReview article

131 Scopus citations

Increased proliferative cells in the medullary thick ascending limb of the loop of henle in the dahl salt-sensitive rat

Yang, C., Stingo, F. C., Ahn, K. W., Liu, P., Vannucci, M., Laud, P. W., Skelton, M., O'Connor, P., Kurth, T., Ryan, R. P., Moreno, C., Tsaih, S. W., Patone, G., Hummel, O., Jacob, H. J., Liang, M. & Cowley, A. W., Jan 1 2013, In : Hypertension. 61, 1, p. 208-215 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Initiation and progression of chronic kidney disease: Can we definitively test the chronic hypoxia hypothesis?

Evans, R. G. & O'Connor, P. M., Nov 1 2013, In : Hypertension. 62, 5, p. 827-828 2 p.

Research output: Contribution to journalComment/debate

10 Scopus citations

Sex differences in ET-1 receptor expression and Ca2+ signaling in the IMCD

Jin, C., Speed, J. S., Hyndman, K. A., O'Connor, P. M. & Pollock, D. M., Oct 15 2013, In : American Journal of Physiology - Renal Physiology. 305, 8, p. F1099-F1104

Research output: Contribution to journalArticle

18 Scopus citations
2012

Increased expression of NAD(P)H oxidase subunit p67 phox in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension

Feng, D., Yang, C., Geurts, A. M., Kurth, T., Liang, M., Lazar, J., Mattson, D. L., O'Connor, P. M. & Cowley, A. W., Feb 8 2012, In : Cell Metabolism. 15, 2, p. 201-208 8 p.

Research output: Contribution to journalArticle

91 Scopus citations

Increase of sodium delivery stimulates the mitochondrial respiratory chain H 2O 2 production in rat renal medullary thick ascending limb

Ohsaki, Y., O'Connor, P., Mori, T., Ryan, R. P., Dickinson, B. C., Chang, C. J., Lu, Y., Ito, S. & Cowley, A. W., Jan 1 2012, In : American Journal of Physiology - Renal Physiology. 302, 1, p. 95-102 8 p.

Research output: Contribution to journalArticle

31 Scopus citations
15 Scopus citations

Oxygen, free radicals, and the kidney

O'Connor, P. M., Schreck, C. M. & Evans, R. G., May 1 2012, Systems Biology of Free Radicals and Antioxidants. Springer-Verlag Berlin Heidelberg, p. 2563-2580 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2011

A mathematical model of diffusional shunting of oxygen from arteries to veins in the kidney

Gardiner, B. S., Smith, D. W., O'Connor, P. M. & Evans, R. G., Jun 1 2011, In : American Journal of Physiology - Renal Physiology. 300, 6, p. F1339-F1352

Research output: Contribution to journalArticle

38 Scopus citations

Factors that render the kidney susceptible to tissue hypoxia in hypoxemia

Evans, R. G., Goddard, D., Eppel, G. A. & O'Connor, P. M., Apr 1 2011, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300, 4, p. R931-R940

Research output: Contribution to journalArticle

35 Scopus citations

NAD(P)H oxidase and renal epithelial ion transport

Schreck, C. & O'Connor, P. M., May 2011, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300, 5, p. R1023-R1029

Research output: Contribution to journalReview article

40 Scopus citations
23 Scopus citations
2010

Local maximum oxygen disappearance rate has limited utility as a measure of local renal tissue oxygen consumption

Nematbakhsh, M., Eppel, G. A., Goddard, D., O'Connor, P. M. & Evans, R. G., May 1 2010, In : Journal of Pharmacological and Toxicological Methods. 61, 3, p. 297-303 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Modulation of pressure-natriuresis by renal medullary reactive oxygen species and nitric oxide

O'Connor, P. M. & Cowley, A. W., Apr 1 2010, In : Current Hypertension Reports. 12, 2, p. 86-92 7 p.

Research output: Contribution to journalReview article

42 Scopus citations

Multiple mechanisms act to maintain kidney oxygenation during renal ischemia in anesthetized rabbits

Evans, R. G., Eppel, G. A., Michaels, S., Burke, S. L., Nematbakhsh, M., Head, G. A., Carroll, J. F. & O'Connor, P. M., May 2010, In : American Journal of Physiology - Renal Physiology. 298, 5, p. F1235-F1243

Research output: Contribution to journalArticle

31 Scopus citations

Resurrecting hope for antioxidant treatment of cardiovascular disease: Focus on mitochondria

O'Connor, P. M. & Gutterman, D. D., Jul 9 2010, In : Circulation research. 107, 1, p. 9-11 3 p.

Research output: Contribution to journalEditorial

13 Scopus citations
20 Scopus citations
2009

A novel amiloride-sensitive h+ transport pathway mediates enhanced superoxide production in thick ascending limb of salt-sensitive rats, not Na+/H+ Exchange

O'Connor, P. M., Lu, L., Liang, M. & Cowley, A. W., Aug 1 2009, In : Hypertension. 54, 2, p. 248-254 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2008

Enhanced amiloride-sensitive superoxide production in renal medullary thick ascending limb of Dahl salt-sensitive rats

O'Connor, P. M., Lu, L., Schreck, C. & Cowley, A. W., Sep 1 2008, In : American Journal of Physiology - Renal Physiology. 295, 3, p. F726-F733

Research output: Contribution to journalArticle

19 Scopus citations

Intrarenal oxygenation: Unique challenges and the biophysical basis of homeostasis

Evans, R. G., Gardiner, B. S., Smith, D. W. & O'Connor, P. M., Nov 1 2008, In : American Journal of Physiology - Renal Physiology. 295, 5, p. F1259-F1270

Research output: Contribution to journalReview article

172 Scopus citations

Measurement of renal tissue oxygen tension: Systematic differences between fluorescence optode and microelectrode recordings in anaesthetized rabbits

Leong, C. L., O'Connor, P. M., Eppel, G. A., Anderson, W. P. & Evans, R. G., Mar 1 2008, In : Nephron - Physiology. 108, 2

Research output: Contribution to journalArticle

19 Scopus citations

Methods for studying the physiology of kidney oxygenation

Evans, R. G., Gardiner, B. S., Smith, D. W. & O'Connor, P. M., Dec 1 2008, In : Clinical and Experimental Pharmacology and Physiology. 35, 12, p. 1405-1412 8 p.

Research output: Contribution to journalShort survey

41 Scopus citations

Simultaneous measurement of pO2 and perfusion in the rabbit kidney in vivo

O'Connor, P. M., Anderson, W. P., Kett, M. M. & Evans, R. G., Jan 1 2008, Advances in Experimental Medicine and Biology. Springer New York, p. 93-99 7 p. (Advances in Experimental Medicine and Biology; vol. 599).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations
2007

Don't be so BOLD: Potential limitations in the use of BOLD MRI for studies of renal oxygenation [7]

Evans, R. G., Leong, C. L., Anderson, W. P. & O'Connor, P. M., Jun 1 2007, In : Kidney International. 71, 12, p. 1327-1328 2 p.

Research output: Contribution to journalLetter

23 Scopus citations