Pediatric Hematology/Oncology

Research Output 1987 2019

2019
1 Citation (Scopus)

Conjugate prodrug AN-233 induces fetal hemoglobin expression in sickle erythroid progenitors and β-YAC transgenic mice

Oseghale, A. R., Zhu, X., Li, B., Peterson, K. R., Nudelman, A., Rephaeli, A., Xu, H. & Pace, B. S., Nov 1 2019, In : Blood Cells, Molecules, and Diseases. 79, 102345.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
Prodrugs
Transgenic Mice
Sickle Cell Anemia
1 Citation (Scopus)

Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality

Thangavelu, G., Lee, Y. C., Loschi, M., Melanie Schaechter, K., Feser, C. J., Koehn, B. H., Nowak, E. C., Zeiser, R., Serody, J. S., Murphy, W. J., Munn, D. H., Chambon, P., Noelle, R. J. & Blazar, B. R., May 1 2019, In : Journal of Immunology. 202, 9, p. 2795-2805 11 p.

Research output: Contribution to journalArticle

Retinal Dehydrogenase
Aldehyde Dehydrogenase
Graft vs Host Disease
Tretinoin
Dendritic Cells
2 Citations (Scopus)

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression

Cao, Y., Trillo-Tinoco, J., Sierra, R. A., Anadon, C., Dai, W., Mohamed, E., Cen, L., Costich, T. L., Magliocco, A., Marchion, D., Klar, R., Michel, S., Jaschinski, F., Reich, R. R., Mehrotra, S., Cubillos-Ruiz, J. R., Munn, D. H., Conejo-Garcia, J. R. & Rodriguez, P. C., Dec 1 2019, In : Nature Communications. 10, 1, 1280.

Research output: Contribution to journalArticle

Open Access
Transcription Factor CHOP
effectors
endoplasmic reticulum
Endoplasmic Reticulum Stress
Tumors
2 Citations (Scopus)

Mechanisms of NRF2 activation to mediate fetal hemoglobin induction and protection against oxidative stress in sickle cell disease

Zhu, X., Oseghale, A. R., Nicole, L. H., Li, B. & Pace, B. S., Feb 1 2019, In : Experimental Biology and Medicine. 244, 2, p. 171-182 12 p.

Research output: Contribution to journalReview article

Fetal Hemoglobin
Oxidative stress
Sickle Cell Anemia
Oxidative Stress
Sickle Hemoglobin
8 Citations (Scopus)

MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease

Li, B., Zhu, X., Ward, C. M., Starlard-Davenport, A., Takezaki, M., Berry, A., Ward, A., Wilder, C., Neunert, C., Kutlar, A. & Pace, B. S., Feb 2019, In : Experimental Hematology. 70, p. 85-96.e5

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
Sickle Cell Anemia
Gene Silencing
MicroRNAs
1 Citation (Scopus)

MIR29B mediates epigenetic mechanisms of HBG gene activation

Starlard-Davenport, A., Smith, A., Vu, L., Li, B. & Pace, B. S., Jul 2019, In : British Journal of Haematology. 186, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Epigenomics
Transcriptional Activation
Methyltransferases
Cytidine Deaminase

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

Paz, K., Flynn, R., Du, J., Tannheimer, S., Johnson, A. J., Dong, S., Stark, A. K., Okkenhaug, K., Panoskaltsis-Mortari, A., Sage, P. T., Sharpe, A. H., Luznik, L., Ritz, J., Soiffer, R. J., Cutler, C. S., Koreth, J., Antin, J. H., Miklos, D. B., MacDonald, K. P., Hill, G. R. & 10 others, Maillard, I., Serody, J. S., Murphy, W. J., Munn, D. H., Feser, C., Zaiken, M., Vanhaesebroeck, B., Turka, L. A., Byrd, J. C. & Blazar, B. R., Jun 2019, In : American Journal of Transplantation. 19, 6, p. 1820-1830 11 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Graft vs Host Disease
Germinal Center
Bronchiolitis Obliterans
B-Lymphocytes
2018
1 Citation (Scopus)

Access to hematopoietic stem cell transplant for patients with sickle cell anemia

Meier, E. R., Johnson, T. S., Pinkney, K., Velez, M. C., Kamani, N. & Odame, I., Sep 1 2018, In : Pediatric Blood and Cancer. 65, 9, e27105.

Research output: Contribution to journalReview article

Hematopoietic Stem Cell Transplantation
Sickle Cell Anemia
Hematopoietic Stem Cells
Transplants
Siblings
25 Citations (Scopus)

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

Sharma, M. D., Rodriguez, P. C., Koehn, B. H., Baban, B., Cui, Y., Guo, G., Shimoda, M., Pacholczyk, R. W., Shi, H., Lee, E. J., Xu, H., Johnson, T. S., He, Y., Mergoub, T., Venable, C., Bronte, V., Wolchok, J. D., Blazar, B. R. & Munn, D. H., Jan 16 2018, In : Immunity. 48, 1, p. 91-106.e6

Research output: Contribution to journalArticle

Antigen-Presenting Cells
Myeloid Cells
Immunotherapy
Cell Differentiation
Cross-Priming
5 Citations (Scopus)

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

Habtetsion, T., Ding, Z-C., Pi, W., Li, T., Lu, C., Chen, T., Xi, C., Spartz, H., Liu, K., Hao, Z., Mivechi, N. F., Huo, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Aug 7 2018, In : Cell Metabolism. 28, 2, p. 228-242.e6

Research output: Contribution to journalArticle

Oxidative Stress
Cell Death
T-Lymphocytes
Adoptive Immunotherapy
Neoplasms
23 Citations (Scopus)

Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans article

Shinde, R., Hezaveh, K., Halaby, M. J., Kloetgen, A., Chakravarthy, A., Da Silva Medina, T., Deol, R., Manion, K. P., Baglaenko, Y., Eldh, M., Lamorte, S., Wallace, D., Chodisetti, S. B., Ravishankar, B., Liu, H., Chaudhary, K., Munn, D. H., Tsirigos, A., Madaio, M. P., Gabrielsson, S. & 4 others, Touma, Z., Wither, J., De Carvalho, D. D. & McGaha, T. L., Jun 1 2018, In : Nature Immunology. 19, 6, p. 571-582 12 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Phagocytes
Peripheral Tolerance
Pattern Recognition Receptors
DNA
8 Citations (Scopus)

Enhanced Sensitivity of Patient-Derived Pediatric High-Grade Brain Tumor Xenografts to Oncolytic HSV-1 Virotherapy Correlates with Nectin-1 Expression

Friedman, G. K., Bernstock, J. D., Chen, D., Nan, L., Moore, B. P., Kelly, V. M., Youngblood, S. L., Langford, C. P., Han, X., Ring, E. K., Beierle, E. A., Gillespie, G. Y. & Markert, J. M., Dec 1 2018, In : Scientific Reports. 8, 1, 13930.

Research output: Contribution to journalArticle

Oncolytic Viruses
Human Herpesvirus 1
Heterografts
Brain Neoplasms
Glioblastoma
3 Citations (Scopus)

Fetal hemoglobin induction in sickle erythroid progenitors using a synthetic zinc finger DNA-binding domain

Li, B., Zhu, X., Hossain, M. A., Guy, C. R., Xu, H., Bungert, J. & Pace, B. S., Aug 31 2018, In : Haematologica. 103, 9, p. e384-e387

Research output: Contribution to journalLetter

Fetal Hemoglobin
Zinc Fingers
DNA
9 Citations (Scopus)

Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model

Zhu, X., Xi, C., Thomas, B. & Pace, B. S., Feb 1 2018, In : Blood. 131, 5, p. 558-562 5 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Transgenic Mice
Fetal Hemoglobin
Oxidative stress
Reactive Oxygen Species

Perspective: Sistas in science - Cracking the glass ceiling

Starlard-Davenport, A., Rich, A., Fasipe, T., Lance, E. I., Adekola, K., Forray, A., Steed, M., Fitzgerald, A., Walker, S. & Pace, B. S., Sep 1 2018, In : Ethnicity and Disease. 28, 4, p. 575-578 4 p.

Research output: Contribution to journalReview article

Mentors
National Heart, Lung, and Blood Institute (U.S.)
Negotiating
Practice Guidelines
Research
22 Citations (Scopus)

Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors

Nayak-Kapoor, A., Hao, Z., Sadek, R., Dobbins, R., Marshall, L., Vahanian, N. N., Jay Ramsey, W., Kennedy, E., Mautino, M. R., Link, C. J., Lin, R. S., Royer-Joo, S., Liang, X., Salphati, L., Morrissey, K. M., Mahrus, S., McCall, B., Pirzkall, A., Munn, D. H., Janik, J. E. & 1 others, Khleif, S. N., Jun 20 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 61.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Kynurenine
Half-Life
Neoplasms
Tryptophan
5 Citations (Scopus)

The host protecting the tumor from the host — targeting PD‑L1 expressed by host cells

Munn, D. H., Feb 1 2018, In : Journal of Clinical Investigation. 128, 2, p. 570-572 3 p.

Research output: Contribution to journalReview article

Neoplasms
Tumor Escape
T-Cell Antigen Receptor
Immunity
Therapeutics
4 Citations (Scopus)

The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease

McDonald-Hyman, C., Muller, J. T., Loschi, M., Thangavelu, G., Saha, A., Kumari, S., Reichenbach, D. K., Smith, M. J., Zhang, G., Koehn, B. H., Lin, J., Mitchell, J. S., Fife, B. T., Panoskaltsis-Mortari, A., Feser, C. J., Kirchmeier, A. K., Osborn, M. J., Hippen, K. L., Kelekar, A., Serody, J. S. & 6 others, Turka, L. A., Munn, D. H., Chi, H., Neubert, T. A., Dustin, M. L. & Blazar, B. R., Oct 1 2018, In : Journal of Clinical Investigation. 128, 10, p. 4604-4621 18 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Graft vs Host Disease
Vimentin
Regulatory T-Lymphocytes
Protein Kinase C
13 Citations (Scopus)

Treg Destabilization and reprogramming: Implications for cancer immunotherapy

Munn, D. H., Sharma, M. D. & Johnson, T. S., Sep 15 2018, In : Cancer Research. 78, 18, p. 5191-5199 9 p.

Research output: Contribution to journalReview article

Immunotherapy
Neoplasms
PTEN Phosphohydrolase
Cross-Priming
Indoleamine-Pyrrole 2,3,-Dioxygenase
2017
2 Citations (Scopus)

Adjuvant IL-7 potentiates adoptive T cell therapy by amplifying and sustaining polyfunctional antitumor CD4+ T cells

Ding, Z-C., Habtetsion, T., Cao, Y., Li, T., Liu, C., Kuczma, M., Chen, T., Hao, Z., Bryan, L. J., Munn, D. H. & Zhou, G., Dec 1 2017, In : Scientific Reports. 7, 1, 12168.

Research output: Contribution to journalArticle

Interleukin-7
Cell- and Tissue-Based Therapy
T-Lymphocytes
Cytokines
Adoptive Immunotherapy
7 Citations (Scopus)

A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression

Mangaonkar, A., Mondal, A. K., Fulzule, S., Pundkar, C., Park, E. J., Jillella, A., Kota, V., Xu, H., Savage, N. M., Shi, H., Munn, D. & Kolhe, R., Dec 1 2017, In : Scientific Reports. 7, 1, 12892.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Acute Myeloid Leukemia
Mortality
Messenger RNA
Bone Marrow
16 Citations (Scopus)

Checkpoint proteins in pediatric brain and extracranial solid tumors: Opportunities for immunotherapy

Ring, E. K., Markert, J. M., Gillespie, G. Y. & Friedman, G. K., Jan 15 2017, In : Clinical Cancer Research. 23, 2, p. 342-350 9 p.

Research output: Contribution to journalReview article

Immunotherapy
Pediatrics
Brain
Neoplasms
Proteins
8 Citations (Scopus)

Chemo-immunotherapy: Role of indoleamine 2,3-dioxygenase in defining immunogenic versus tolerogenic cell death in the tumor microenvironment

Johnson, T. S., McGaha, T. L. & Munn, D. H., Jan 1 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 91-104 14 p. (Advances in Experimental Medicine and Biology; vol. 1036).

Research output: Chapter in Book/Report/Conference proceedingChapter

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumor Microenvironment
Cell death
Chemotherapy
Immunotherapy
5 Citations (Scopus)

Development and evaluation of two abbreviated questionnaires for mentoring and research self-efficacy

Jeffe, D. B., Rice, T. K., Boyington, J. E. A., Rao, D. C., Jean-Louis, G., Dávila-Román, V. G., Taylor, A. L., Pace, B. S. & Boutjdir, M., Mar 1 2017, In : Ethnicity and Disease. 27, 2, p. 179-188 10 p.

Research output: Contribution to journalArticle

Self Efficacy
Mentors
Research
Equipment and Supplies
Publications
7 Citations (Scopus)

Early career mentoring through the American Society of Pediatric Hematology/Oncology: Lessons learned from a pilot program

Badawy, S. M., Black, V., Meier, E. R., Myers, K. C., Pinkney, K., Hastings, C., Hilden, J. M., Zweidler-McKay, P., Stork, L. C., Johnson, T. S. & Vaiselbuh, S. R., Mar 1 2017, In : Pediatric Blood and Cancer. 64, 3, e26252.

Research output: Contribution to journalArticle

Mentors
Hematology
Pediatrics
Program Evaluation
Postal Service
3 Citations (Scopus)

Enhancing diversity in the hematology biomedical research workforce: A mentoring program to improve the odds of career success for early stage investigators

Pace, B. S., Makala, L. H., Sarkar, R., Liu, L., Takezaki, M., Mohandas, N., Dixon, G., Werner, E. M., Jeffe, D. B., Rice, T. K., Maihle, N. J. & González, J., Dec 2017, In : American Journal of Hematology. 92, 12, p. 1275-1279 5 p.

Research output: Contribution to journalComment/debate

15 Citations (Scopus)

IDO, PTEN-expressing Tregs and control of antigen-presentation in the murine tumor microenvironment

Munn, D. H., Sharma, M. D., Johnson, T. S. & Rodriguez, P., Aug 1 2017, In : Cancer Immunology, Immunotherapy. 66, 8, p. 1049-1058 10 p.

Research output: Contribution to journalReview article

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumor Microenvironment
Antigen Presentation
Immunosuppressive Agents
Cytotoxins
1 Citation (Scopus)

Impaired pulmonary endothelial barrier function in sickle cell mice

Umapathy, N. S., Gonzales, J., Makala, L. H., Xu, H., Biddinger, P. & Pace, B. S., Jan 1 2017, In : Haematologica. 102, 1, p. e26-e29

Research output: Contribution to journalLetter

10 Citations (Scopus)

In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines

Hippen, K. L., O'Connor, R. S., Lemire, A. M., Saha, A., Hanse, E. A., Tennis, N. C., Merkel, S. C., Kelekar, A., Riley, J. L., Levine, B. L., June, C. H., Turka, L. A., Kean, L. S., MacMillan, M. L., Miller, J. S., Wagner, J. E., Munn, D. H. & Blazar, B. R., Dec 2017, In : American Journal of Transplantation. 17, 12, p. 3098-3113 16 p.

Research output: Contribution to journalArticle

Kynurenine
Regulatory T-Lymphocytes
Tryptophan
Graft vs Host Disease
Interleukin-2
3 Citations (Scopus)

Mentored training to increase diversity among faculty in the biomedical sciences: The NHL BI Summer Institute Programs to Increase Diversity (SI PID ) and the Programs to Increase Diversity among Individuals Engaged in Health-related Research (PRIDE )

Rice, T. K., Jeffe, D. B., Boyington, J. E. A., Jobe, J. B., Dávila-Román, V. G., Gonzalez, J. E., De Las Fuentes, L., Makala, L. H. C., Sarkar, R., Ogedegbe, G. G., Taylor, A. L., Czajkowski, S., Rao, D. C., Pace, B. S., Jean-Louis, G. & Boutjdir, M., Jun 1 2017, In : Ethnicity and Disease. 27, 3, p. 249-256 8 p.

Research output: Contribution to journalArticle

Health
Research
Hispanic Americans
Research Personnel
Education
2 Citations (Scopus)

Newly Characterized Murine Undifferentiated Sarcoma Models Sensitive to Virotherapy with Oncolytic HSV-1 M002

Ring, E. K., Li, R., Moore, B. P., Nan, L., Kelly, V. M., Han, X., Beierle, E. A., Markert, J. M., Leavenworth, J. W., Gillespie, G. Y. & Friedman, G. K., Dec 15 2017, In : Molecular Therapy - Oncolytics. 7, p. 27-36 10 p.

Research output: Contribution to journalArticle

Oncolytic Viruses
Human Herpesvirus 1
Sarcoma
Interleukin-12
Immune System
8 Citations (Scopus)

NRF2 mediates γ-globin gene regulation and fetal hemoglobin induction in human erythroid progenitors

Zhu, X., Li, B. & Pace, B. S., Jul 31 2017, In : Haematologica. 102, 8, p. e285-e288

Research output: Contribution to journalLetter

gamma-Globins
Fetal Hemoglobin
Genes

Overcoming immune suppression in the tumor microenvironment: Implications for multi-modal therapy

Johnson, T. S. & Munn, D. H., Jan 1 2017, Immunotherapy for Pediatric Malignancies. Springer International Publishing, p. 13-38 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tumor Microenvironment
T-Lymphocytes
Neoplasm Antigens
Immunotherapy
Immunosuppressive Agents
8 Citations (Scopus)

Promoter methylation modulates indoleamine 2,3-dioxygenase 1 induction by activated T cells in human breast cancers

Noonepalle, S. K., Gu, F., Lee, E. J., Choi, J. H., Han, Q., Kim, J., Ouzounova, M., Shull, A. Y., Pei, L., Hsu, P. Y., Kolhe, R., Shi, F., Choi, J., Chiou, K., Huang, T. H. M., Korkaya, H., Deng, L., Xin, H. B., Huang, S., Thangaraju, M. & 5 others, Sreekumar, A., Ambs, S., Tang, S. C., Munn, D. H. & Shi, H., Apr 2017, In : Cancer Immunology Research. 5, 4, p. 330-344 15 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Methylation
Triple Negative Breast Neoplasms
Breast Neoplasms
T-Lymphocytes
1 Citation (Scopus)

Stroke in a child with hemoglobin SC disease: A case report describing use of hydroxyurea after transfusion therapy

Fridlyand, D., Wilder, C., Clay, E. L. J., Gilbert, B. & Pace, B. S., Jan 1 2017, In : Pediatric Reports. 9, 1, 6984.

Research output: Contribution to journalArticle

Hemoglobin SC Disease
Hydroxyurea
Stroke
Fetal Hemoglobin
Cerebral Infarction

TFE3-positive renal cell carcinoma occurring in three children with dysfunctional kidneys on immunosuppression

Schaefer, B. A., Johnson, T. S., Hooper, D. K., Nathan, J. D. & Geller, J. I., Jun 2017, In : Pediatric Transplantation. 21, 4, e12912.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Immunosuppression
Pediatrics
Kidney
Chronic Renal Insufficiency
2016
4 Citations (Scopus)

Activation of Fetal γ-globin Gene Expression via Direct Protein Delivery of Synthetic Zinc-finger DNA-Binding Domains

Hossain, M. A., Shen, Y., Knudson, I., Thakur, S., Stees, J. R., Qiu, Y., Pace, B. S., Peterson, K. R. & Bungert, J., Jan 1 2016, In : Molecular Therapy - Nucleic Acids. 5, p. e378

Research output: Contribution to journalArticle

Globins
Zinc Fingers
Gene Expression
DNA
Fetal Hemoglobin
8 Citations (Scopus)

A perspective on promoting diversity in the biomedical research workforce: The national heart, lung, and blood institute's pri de program

Boyington, J. E. A., Maihle, N. J., Rice, T. K., Gonzalez, J. E., Hess, C. A., Makala, L. H., Jeffe, D. B., Ogedegbe, G., Rao, D. C., Dávila-Román, V. G., Pace, B. S., Jean-Louis, G. & Boutjdir, M., Jun 1 2016, In : Ethnicity and Disease. 26, 3, p. 379-386 8 p.

Research output: Contribution to journalReview article

National Heart, Lung, and Blood Institute (U.S.)
Biomedical Research
Research
Health
Research Personnel
4 Citations (Scopus)

Biomechanical and biochemical regulation of cathepsin K expression in endothelial cells converge at AP-1 and NF-κB

Keegan, P. M., Anbazhakan, S., Kang, B., Pace, B. S. & Platt, M. O., May 1 2016, In : Biological Chemistry. 397, 5, p. 459-468 10 p.

Research output: Contribution to journalArticle

Cathepsin K
Endothelial cells
Transcription Factor AP-1
Endothelial Cells
Shear stress
17 Citations (Scopus)

Deletion of LRP5 and LRP6 in dendritic cells enhances antitumor immunity

Hong, Y., Manoharan, I., Suryawanshi, A., Shanmugam, A., Swafford, D., Ahmad, S., Chinnadurai, R., Manicassamy, B., He, Y., Mellor, A. L., Thangaraju, M., Munn, D. H. & Manicassamy, S., Apr 2 2016, In : OncoImmunology. 5, 4

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-6
Low Density Lipoprotein Receptor-Related Protein-5
Dendritic Cells
Immunity
Tumor Microenvironment
222 Citations (Scopus)

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

Munn, D. H. & Mellor, A. L., Mar 1 2016, In : Trends in Immunology. 37, 3, p. 193-207 15 p.

Research output: Contribution to journalReview article

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumor Microenvironment
Inflammation
Immunotherapy
Regulatory T-Lymphocytes
7 Citations (Scopus)

IL-7 signaling imparts polyfunctionality and stemness potential to CD4+ T cells

Ding, Z-C., Liu, C., Cao, Y., Habtetsion, T., Kuczma, M., Pi, W., Kong, H., Cacan, E., Greer, S. F., Cui, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Jun 2 2016, In : OncoImmunology. 5, 6, e1171445.

Research output: Contribution to journalArticle

Interleukin-7
T-Lymphocytes
Aptitude
Immunotherapy
Neoplasms
146 Citations (Scopus)

Immune suppressive mechanisms in the tumor microenvironment

Munn, D. H. & Bronte, V., Apr 1 2016, In : Current Opinion in Immunology. 39, p. 1-6 6 p.

Research output: Contribution to journalReview article

Tumor Microenvironment
Immunotherapy
Immunosuppressive Agents
Neoplasms
Myeloid Cells
9 Citations (Scopus)

Minireview: Multiomic candidate biomarkers for clinical manifestations of sickle cell severity: Early steps to precision medicine

Goodman, S. R., Pace, B. S., Hansen, K. C., D’alessandro, A., Xia, Y., Daescu, O. & Glatt, S. J., Jan 1 2016, In : Experimental Biology and Medicine. 241, 7, p. 772-781 10 p.

Research output: Contribution to journalArticle

Precision Medicine
Biomarkers
Medicine
Sickle Cell Anemia
Retrospective Studies
17 Citations (Scopus)

MiR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency

Lu, Y., Hippen, K. L., Lemire, A. L., Gu, J., Wang, W., Ni, X., Ranganathan, P., Levine, B. L., Riley, J. L., June, C. H., Turka, L. A., Munn, D. H., Garzon, R., Lu, L. & Blazar, B. R., Sep 8 2016, In : Blood. 128, 10, p. 1424-1435 12 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Graft vs Host Disease
MicroRNAs
T-cells
Grafts
7 Citations (Scopus)

Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease

Liu, L., Pertsemlidis, A., Ding, L. H., Story, M. D., Steinberg, M. H., Sebastiani, P., Hoppe, C., Ballas, S. K. & Pace, B. S., Jan 1 2016, In : Experimental Biology and Medicine. 241, 7, p. 706-718 13 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
Genome-Wide Association Study
Sickle Cell Anemia
Single Nucleotide Polymorphism
7 Citations (Scopus)

Original Research: Stable expression of miR-34a mediates fetal hemoglobin induction in K562 cells

Ward, C. M., Li, B. & Pace, B. S., Jan 1 2016, In : Experimental Biology and Medicine. 241, 7, p. 719-729 11 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
K562 Cells
Genes
Histone Deacetylase 1

Personalized chemotherapy of tumor disease based on system modeling

Li, B., Jan 1 2016, Frontiers in Drug Design and Discovery. 1 ed. Bentham Science Publishers B.V., p. 223-247 25 p. (Frontiers in Drug Design and Discovery; vol. 7, no. 1).

Research output: Chapter in Book/Report/Conference proceedingChapter

Drug Therapy
Precision Medicine
Neoplasms
Drug Discovery
Therapeutics
38 Citations (Scopus)

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality

Saha, A., O'Connor, R. S., Thangavelu, G., Lovitch, S. B., Dandamudi, D. B., Wilson, C. B., Vincent, B. G., Tkachev, V., Pawlicki, J. M., Furlan, S. N., Kean, L. S., Aoyama, K., Taylor, P. A., Panoskaltsis-Mortari, A., Foncea, R., Ranganathan, P., Devine, S. M., Burrill, J. S., Guo, L., Sacristan, C. & 15 others, Snyder, N. W., Blair, I. A., Milone, M. C., Dustin, M. L., Riley, J. L., Bernlohr, D. A., Murphy, W. J., Fife, B. T., Munn, D. H., Miller, J. S., Serody, J. S., Freeman, G. J., Sharpe, A. H., Turka, L. A. & Blazar, B. R., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2642-2660 19 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Tissue Donors
Ligands
T-Lymphocytes
Transplants
1 Citation (Scopus)

Sickle cell disease severity: an introduction

Pace, B. S. & Goodman, S. R., Jan 1 2016, In : Experimental Biology and Medicine. 241, 7, p. 677-678 2 p.

Research output: Contribution to journalArticle

Sickle Hemoglobin
Fetal Hemoglobin
Hydroxyurea
Biomarkers