Pediatric Hematology/Oncology

Research Output 1987 2019

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Review article
2019
2 Citations (Scopus)

Mechanisms of NRF2 activation to mediate fetal hemoglobin induction and protection against oxidative stress in sickle cell disease

Zhu, X., Oseghale, A. R., Nicole, L. H., Li, B. & Pace, B. S., Feb 1 2019, In : Experimental Biology and Medicine. 244, 2, p. 171-182 12 p.

Research output: Contribution to journalReview article

Fetal Hemoglobin
Oxidative stress
Sickle Cell Anemia
Oxidative Stress
Sickle Hemoglobin
2018
1 Citation (Scopus)

Access to hematopoietic stem cell transplant for patients with sickle cell anemia

Meier, E. R., Johnson, T. S., Pinkney, K., Velez, M. C., Kamani, N. & Odame, I., Sep 1 2018, In : Pediatric Blood and Cancer. 65, 9, e27105.

Research output: Contribution to journalReview article

Hematopoietic Stem Cell Transplantation
Sickle Cell Anemia
Hematopoietic Stem Cells
Transplants
Siblings

Perspective: Sistas in science - Cracking the glass ceiling

Starlard-Davenport, A., Rich, A., Fasipe, T., Lance, E. I., Adekola, K., Forray, A., Steed, M., Fitzgerald, A., Walker, S. & Pace, B. S., Sep 1 2018, In : Ethnicity and Disease. 28, 4, p. 575-578 4 p.

Research output: Contribution to journalReview article

Mentors
National Heart, Lung, and Blood Institute (U.S.)
Negotiating
Practice Guidelines
Research
5 Citations (Scopus)

The host protecting the tumor from the host — targeting PD‑L1 expressed by host cells

Munn, D. H., Feb 1 2018, In : Journal of Clinical Investigation. 128, 2, p. 570-572 3 p.

Research output: Contribution to journalReview article

Neoplasms
Tumor Escape
T-Cell Antigen Receptor
Immunity
Therapeutics
13 Citations (Scopus)

Treg Destabilization and reprogramming: Implications for cancer immunotherapy

Munn, D. H., Sharma, M. D. & Johnson, T. S., Sep 15 2018, In : Cancer Research. 78, 18, p. 5191-5199 9 p.

Research output: Contribution to journalReview article

Immunotherapy
Neoplasms
PTEN Phosphohydrolase
Cross-Priming
Indoleamine-Pyrrole 2,3,-Dioxygenase
2017
16 Citations (Scopus)

Checkpoint proteins in pediatric brain and extracranial solid tumors: Opportunities for immunotherapy

Ring, E. K., Markert, J. M., Gillespie, G. Y. & Friedman, G. K., Jan 15 2017, In : Clinical Cancer Research. 23, 2, p. 342-350 9 p.

Research output: Contribution to journalReview article

Immunotherapy
Pediatrics
Brain
Neoplasms
Proteins
15 Citations (Scopus)

IDO, PTEN-expressing Tregs and control of antigen-presentation in the murine tumor microenvironment

Munn, D. H., Sharma, M. D., Johnson, T. S. & Rodriguez, P., Aug 1 2017, In : Cancer Immunology, Immunotherapy. 66, 8, p. 1049-1058 10 p.

Research output: Contribution to journalReview article

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumor Microenvironment
Antigen Presentation
Immunosuppressive Agents
Cytotoxins
2016
8 Citations (Scopus)

A perspective on promoting diversity in the biomedical research workforce: The national heart, lung, and blood institute's pri de program

Boyington, J. E. A., Maihle, N. J., Rice, T. K., Gonzalez, J. E., Hess, C. A., Makala, L. H., Jeffe, D. B., Ogedegbe, G., Rao, D. C., Dávila-Román, V. G., Pace, B. S., Jean-Louis, G. & Boutjdir, M., Jun 1 2016, In : Ethnicity and Disease. 26, 3, p. 379-386 8 p.

Research output: Contribution to journalReview article

National Heart, Lung, and Blood Institute (U.S.)
Biomedical Research
Research
Health
Research Personnel
222 Citations (Scopus)

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

Munn, D. H. & Mellor, A. L., Mar 1 2016, In : Trends in Immunology. 37, 3, p. 193-207 15 p.

Research output: Contribution to journalReview article

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumor Microenvironment
Inflammation
Immunotherapy
Regulatory T-Lymphocytes
146 Citations (Scopus)

Immune suppressive mechanisms in the tumor microenvironment

Munn, D. H. & Bronte, V., Apr 1 2016, In : Current Opinion in Immunology. 39, p. 1-6 6 p.

Research output: Contribution to journalReview article

Tumor Microenvironment
Immunotherapy
Immunosuppressive Agents
Neoplasms
Myeloid Cells
18 Citations (Scopus)

Targeting translation: EIF4E as an emerging anticancer drug target

Lu, C., Makala, L., Wu, D. & Cai, Y., Jan 18 2016, In : Expert Reviews in Molecular Medicine. 18, e2.

Research output: Contribution to journalReview article

Eukaryotic Initiation Factor-4E
Peptide Initiation Factors
Cyclin D1
Pharmaceutical Preparations
Vascular Endothelial Growth Factor A
2014
1 Citation (Scopus)

Highlights and summary of the 28th annual meeting of the Society for Immunotherapy of Cancer

Ascierto, P. A., Munn, D. H., Palucka, A. K. & Sondel, P. M., May 15 2014, In : Journal for ImmunoTherapy of Cancer. 2, 1, 15.

Research output: Contribution to journalReview article

Immunotherapy
Allergy and Immunology
Neoplasms
Posters
Medical Oncology
28 Citations (Scopus)

Targeted fetal hemoglobin induction for treatment of beta hemoglobinopathies

Perrine, S. P., Pace, B. S. & Faller, D. V., Apr 1 2014, In : Hematology/Oncology Clinics of North America. 28, 2, p. 233-248 16 p.

Research output: Contribution to journalReview article

Fetal Hemoglobin
Hemoglobinopathies
Thalassemia
Globins
gamma-Globins
2013
418 Citations (Scopus)

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

Munn, D. H. & Mellor, A. L., Mar 1 2013, In : Trends in Immunology. 34, 3, p. 137-143 7 p.

Research output: Contribution to journalReview article

Indoleamine-Pyrrole 2,3,-Dioxygenase
Food
Essential Amino Acids
Adaptive Immunity
Innate Immunity
2012
11 Citations (Scopus)

Modulation of tumor tolerance in primary central nervous system malignancies

Johnson, T. S., Munn, D. H. & Maria, B. L., Mar 19 2012, In : Clinical and Developmental Immunology. 2012, 937253.

Research output: Contribution to journalReview article

Central Nervous System
Neoplasms
Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumor-Infiltrating Lymphocytes
Central Nervous System Neoplasms
9 Citations (Scopus)

The role of indoleamine 2, 3 dioxygenase in regulating host immunity to leishmania infection

Makala, L. H. C., Jan 10 2012, In : Journal of Biomedical Science. 19, 1, 5.

Research output: Contribution to journalReview article

Indoleamine-Pyrrole 2,3,-Dioxygenase
Leishmania
Pathogens
Immunity
Infection
2011
28 Citations (Scopus)

Contemporary diagnostic methods for hemophagocytic lymphohistiocytic disorders

Johnson, T. S., Villanueva, J., Filipovich, A. H., Marsh, R. A. & Bleesing, J. J., Feb 1 2011, In : Journal of Immunological Methods. 364, 1-2, p. 1-13 13 p.

Research output: Contribution to journalReview article

Hemophagocytic Lymphohistiocytosis
Infection
Autoimmune Diseases
Lymphocytes
Neoplasms
68 Citations (Scopus)

Highlights of 10 years of immunology in Nature Reviews Immunology

Medzhitov, R., Shevach, E. M., Trinchieri, G., Mellor, A. L., Munn, D. H., Gordon, S., Libby, P., Hansson, G. K., Shortman, K., Dong, C., Gabrilovich, D., Gabrysǒvá, L., Howes, A. & O'Garra, A., Oct 1 2011, In : Nature Reviews Immunology. 11, 10, p. 693-702 10 p.

Research output: Contribution to journalReview article

Allergy and Immunology
Indoleamine-Pyrrole 2,3,-Dioxygenase
Toll-Like Receptors
Anniversaries and Special Events
Regulatory T-Lymphocytes
46 Citations (Scopus)

Physiologic control of the functional status of Foxp3+ regulatory T cells

Mellor, A. L. & Munn, D. H., Apr 15 2011, In : Journal of Immunology. 186, 8, p. 4535-4540 6 p.

Research output: Contribution to journalReview article

Regulatory T-Lymphocytes
T-Lymphocytes
Self Tolerance
Immunity
Inflammation
95 Citations (Scopus)

Regulatory T cells in acute myelogenous leukemia: Is it time for immunomodulation?

Ustun, C., Miller, J. S., Munn, D. H., Weisdorf, D. J. & Blazar, B. R., Nov 10 2011, In : Blood. 118, 19, p. 5084-5095 12 p.

Research output: Contribution to journalReview article

Chemotherapy
T-cells
Immunomodulation
Immune system
Regulatory T-Lymphocytes
2007
698 Citations (Scopus)

Indoleamine 2,3-dioxygenase and tumor-induced tolerance

Munn, D. H. & Mellor, A. L., May 1 2007, In : Journal of Clinical Investigation. 117, 5, p. 1147-1154 8 p.

Research output: Contribution to journalReview article

Indoleamine-Pyrrole 2,3,-Dioxygenase
Neoplasms
Antigens
Immunotherapy
Mutation
23 Citations (Scopus)

Recombinant lentivector as a genetic immunization vehicle for antitumor immunity

He, Y., Munn, D. H. & Falo, L. D., Dec 1 2007, In : Expert Review of Vaccines. 6, 6, p. 913-924 12 p.

Research output: Contribution to journalReview article

Immunity
Immunization
T-Lymphocytes
Neoplasms
Genetic Vectors
2006
16 Citations (Scopus)

Immune privilege: A recurrent theme in immunoregulation?

Mellor, A. L. & Munn, D. H., Oct 1 2006, In : Immunological Reviews. 213, 1, p. 5-11 7 p.

Research output: Contribution to journalReview article

Immunity
137 Citations (Scopus)

Indoleamine 2,3-dioxygenase, tumor-induced tolerance and counter-regulation

Munn, D. H., Apr 1 2006, In : Current Opinion in Immunology. 18, 2, p. 220-225 6 p.

Research output: Contribution to journalReview article

Indoleamine-Pyrrole 2,3,-Dioxygenase
Neoplasms
Oligodeoxyribonucleotides
Antigen-Presenting Cells
Stromal Cells
140 Citations (Scopus)

The tumor-draining lymph node as an immune-privileged site

Munn, D. H. & Mellor, A. L., Oct 1 2006, In : Immunological Reviews. 213, 1, p. 146-158 13 p.

Research output: Contribution to journalReview article

Lymph Nodes
Neoplasms
Antigen Presentation
Neoplasm Antigens
Autoantigens
2 Citations (Scopus)

Tumor immune evasion mediated by IDO

Munn, D. H., Jun 1 2006, In : Update on Cancer Therapeutics. 1, 2, p. 175-185 11 p.

Research output: Contribution to journalReview article

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumor Escape
Neoplasms
Immunotherapy
Drug Therapy
40 Citations (Scopus)

Understanding mechanisms of γ-globin gene regulation to develop strategies for pharmacological fetal hemoglobin induction

Pace, B. S. & Zein, S., Jul 1 2006, In : Developmental Dynamics. 235, 7, p. 1727-1737 11 p.

Research output: Contribution to journalReview article

Fetal Hemoglobin
Globins
Sickle Cell Anemia
Pharmacology
Developmental Gene Expression Regulation
2005

A cautionary tale

Munn, D. H., May 15 2005, In : Blood. 105, 10, p. 3761-3762 2 p.

Research output: Contribution to journalReview article

Indoleamine-Pyrrole 2,3,-Dioxygenase
Antigen-Presenting Cells
Immunotherapy
Monocytes
5 Citations (Scopus)

A strategy to identify genomic expression at single-cell level or a small number of cells

Li, B., Apr 15 2005, In : Electronic Journal of Biotechnology. 8, 1, p. 71-81 11 p.

Research output: Contribution to journalReview article

Cell Count
Carcinogenesis
Single-Cell Analysis
Gene Expression
Electrophoresis, Gel, Two-Dimensional

Costimulatory blockade: Act II

Munn, D. H., Nov 1 2005, In : Blood. 106, 9, p. 2926-2927 2 p.

Research output: Contribution to journalReview article

B7 Antigens
Dendritic Cells
2004
1570 Citations (Scopus)

IDO expression by dendritic cells: Tolerance and tryptophan catabolism

Mellor, A. L. & Munn, D. H., Oct 1 2004, In : Nature Reviews Immunology. 4, 10, p. 762-774 13 p.

Research output: Contribution to journalReview article

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tryptophan
Dendritic Cells
Essential Amino Acids
Allergy and Immunology
10 Citations (Scopus)

Immunology: Antigen-Presenting Cells in the Gut

Makala, L. H. C., Nishikawa, Y., Suzuki, N. & Nagasawa, H., Mar 11 2004, In : Journal of Biomedical Science. 11, 2, p. 130-141 12 p.

Research output: Contribution to journalReview article

Immunology
Antigen-Presenting Cells
Allergy and Immunology
Mucous Membrane
Peyer's Patches
2003
19 Citations (Scopus)

Macrophages and the regulation of self-reactive T cells

Munn, D. H. & Mellor, A. L., Feb 3 2003, In : Current Pharmaceutical Design. 9, 3, p. 257-264 8 p.

Research output: Contribution to journalReview article

Macrophages
T-Lymphocytes
Autoantigens
Antigen-Presenting Cells
Immunosuppressive Agents
31 Citations (Scopus)

The current status of major tick borne diseases in Zambia

Makala, L. H., Mangani, P., Fujisaki, K. & Nagasawa, H., Jan 1 2003, In : Veterinary Research. 34, 1, p. 27-45 19 p.

Research output: Contribution to journalReview article

Tick-Borne Diseases
Zambia
tick-borne diseases
Acaricides
Research
2002
16 Citations (Scopus)

Dendritic cells: A specialized complex system of antigen presenting cells

Makala, L. H. C. & Nagasawa, H., Mar 1 2002, In : Journal of Veterinary Medical Science. 64, 3, p. 181-193 13 p.

Research output: Contribution to journalReview article

antigen-presenting cells
Antigen-Presenting Cells
dendritic cells
Dendritic Cells
T-lymphocytes
39 Citations (Scopus)

Peyer's patches: Organized lymphoid structures for the induction of mucosal immune responses in the intestine

Makala, L. H. C., Suzuki, N. & Nagasawa, H., Dec 1 2002, In : Pathobiology. 70, 2, p. 55-68 14 p.

Research output: Contribution to journalReview article

Peyer's Patches
Mucosal Immunity
Intestines
Epithelium
History
2000
239 Citations (Scopus)

Immunology at the maternal-fetal interface: Lessons for T cell tolerance and suppression

Mellor, A. L. & Munn, D. H., Jun 27 2000, In : Annual Review of Immunology. 18, p. 367-391 25 p.

Research output: Contribution to journalReview article

Allergy and Immunology
Mothers
T-Lymphocytes
Pregnancy
Isoantigens
1999
20 Citations (Scopus)

Macrophage suppression of T cell activation: A potential mechanism of peripheral tolerance

Attwood, J. T. & Munn, D. H., Jan 1 1999, In : International Reviews of Immunology. 18, 5-6, p. 515-525 11 p.

Research output: Contribution to journalReview article

Peripheral Tolerance
Macrophages
T-Lymphocytes
Antigen-Presenting Cells
Autoantigens
499 Citations (Scopus)

Tryptophan catabolism and T-cell tolerance: Immunosuppression by starvation?

Mellor, A. L. & Munn, D. H., Oct 1 1999, In : Immunology Today. 20, 10, p. 469-473 5 p.

Research output: Contribution to journalReview article

Maternal-Fetal Exchange
Tryptophan Oxygenase
Indoleamine-Pyrrole 2,3,-Dioxygenase
Immune Tolerance
Nitric Oxide Synthase Type II