Pediatric Hematology/Oncology

Research Output 1987 2019

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2019
1 Citation (Scopus)

Conjugate prodrug AN-233 induces fetal hemoglobin expression in sickle erythroid progenitors and β-YAC transgenic mice

Oseghale, A. R., Zhu, X., Li, B., Peterson, K. R., Nudelman, A., Rephaeli, A., Xu, H. & Pace, B. S., Nov 1 2019, In : Blood Cells, Molecules, and Diseases. 79, 102345.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
Prodrugs
Transgenic Mice
Sickle Cell Anemia
1 Citation (Scopus)

Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality

Thangavelu, G., Lee, Y. C., Loschi, M., Melanie Schaechter, K., Feser, C. J., Koehn, B. H., Nowak, E. C., Zeiser, R., Serody, J. S., Murphy, W. J., Munn, D. H., Chambon, P., Noelle, R. J. & Blazar, B. R., May 1 2019, In : Journal of Immunology. 202, 9, p. 2795-2805 11 p.

Research output: Contribution to journalArticle

Retinal Dehydrogenase
Aldehyde Dehydrogenase
Graft vs Host Disease
Tretinoin
Dendritic Cells
2 Citations (Scopus)

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression

Cao, Y., Trillo-Tinoco, J., Sierra, R. A., Anadon, C., Dai, W., Mohamed, E., Cen, L., Costich, T. L., Magliocco, A., Marchion, D., Klar, R., Michel, S., Jaschinski, F., Reich, R. R., Mehrotra, S., Cubillos-Ruiz, J. R., Munn, D. H., Conejo-Garcia, J. R. & Rodriguez, P. C., Dec 1 2019, In : Nature Communications. 10, 1, 1280.

Research output: Contribution to journalArticle

Open Access
Transcription Factor CHOP
effectors
endoplasmic reticulum
Endoplasmic Reticulum Stress
Tumors
8 Citations (Scopus)

MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease

Li, B., Zhu, X., Ward, C. M., Starlard-Davenport, A., Takezaki, M., Berry, A., Ward, A., Wilder, C., Neunert, C., Kutlar, A. & Pace, B. S., Feb 2019, In : Experimental Hematology. 70, p. 85-96.e5

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
Sickle Cell Anemia
Gene Silencing
MicroRNAs
1 Citation (Scopus)

MIR29B mediates epigenetic mechanisms of HBG gene activation

Starlard-Davenport, A., Smith, A., Vu, L., Li, B. & Pace, B. S., Jul 2019, In : British Journal of Haematology. 186, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Epigenomics
Transcriptional Activation
Methyltransferases
Cytidine Deaminase

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

Paz, K., Flynn, R., Du, J., Tannheimer, S., Johnson, A. J., Dong, S., Stark, A. K., Okkenhaug, K., Panoskaltsis-Mortari, A., Sage, P. T., Sharpe, A. H., Luznik, L., Ritz, J., Soiffer, R. J., Cutler, C. S., Koreth, J., Antin, J. H., Miklos, D. B., MacDonald, K. P., Hill, G. R. & 10 others, Maillard, I., Serody, J. S., Murphy, W. J., Munn, D. H., Feser, C., Zaiken, M., Vanhaesebroeck, B., Turka, L. A., Byrd, J. C. & Blazar, B. R., Jun 2019, In : American Journal of Transplantation. 19, 6, p. 1820-1830 11 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Graft vs Host Disease
Germinal Center
Bronchiolitis Obliterans
B-Lymphocytes
2018
25 Citations (Scopus)

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

Sharma, M. D., Rodriguez, P. C., Koehn, B. H., Baban, B., Cui, Y., Guo, G., Shimoda, M., Pacholczyk, R. W., Shi, H., Lee, E. J., Xu, H., Johnson, T. S., He, Y., Mergoub, T., Venable, C., Bronte, V., Wolchok, J. D., Blazar, B. R. & Munn, D. H., Jan 16 2018, In : Immunity. 48, 1, p. 91-106.e6

Research output: Contribution to journalArticle

Antigen-Presenting Cells
Myeloid Cells
Immunotherapy
Cell Differentiation
Cross-Priming
5 Citations (Scopus)

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

Habtetsion, T., Ding, Z-C., Pi, W., Li, T., Lu, C., Chen, T., Xi, C., Spartz, H., Liu, K., Hao, Z., Mivechi, N. F., Huo, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Aug 7 2018, In : Cell Metabolism. 28, 2, p. 228-242.e6

Research output: Contribution to journalArticle

Oxidative Stress
Cell Death
T-Lymphocytes
Adoptive Immunotherapy
Neoplasms
23 Citations (Scopus)

Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans article

Shinde, R., Hezaveh, K., Halaby, M. J., Kloetgen, A., Chakravarthy, A., Da Silva Medina, T., Deol, R., Manion, K. P., Baglaenko, Y., Eldh, M., Lamorte, S., Wallace, D., Chodisetti, S. B., Ravishankar, B., Liu, H., Chaudhary, K., Munn, D. H., Tsirigos, A., Madaio, M. P., Gabrielsson, S. & 4 others, Touma, Z., Wither, J., De Carvalho, D. D. & McGaha, T. L., Jun 1 2018, In : Nature Immunology. 19, 6, p. 571-582 12 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Phagocytes
Peripheral Tolerance
Pattern Recognition Receptors
DNA
8 Citations (Scopus)

Enhanced Sensitivity of Patient-Derived Pediatric High-Grade Brain Tumor Xenografts to Oncolytic HSV-1 Virotherapy Correlates with Nectin-1 Expression

Friedman, G. K., Bernstock, J. D., Chen, D., Nan, L., Moore, B. P., Kelly, V. M., Youngblood, S. L., Langford, C. P., Han, X., Ring, E. K., Beierle, E. A., Gillespie, G. Y. & Markert, J. M., Dec 1 2018, In : Scientific Reports. 8, 1, 13930.

Research output: Contribution to journalArticle

Oncolytic Viruses
Human Herpesvirus 1
Heterografts
Brain Neoplasms
Glioblastoma
9 Citations (Scopus)

Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model

Zhu, X., Xi, C., Thomas, B. & Pace, B. S., Feb 1 2018, In : Blood. 131, 5, p. 558-562 5 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Transgenic Mice
Fetal Hemoglobin
Oxidative stress
Reactive Oxygen Species
22 Citations (Scopus)

Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors

Nayak-Kapoor, A., Hao, Z., Sadek, R., Dobbins, R., Marshall, L., Vahanian, N. N., Jay Ramsey, W., Kennedy, E., Mautino, M. R., Link, C. J., Lin, R. S., Royer-Joo, S., Liang, X., Salphati, L., Morrissey, K. M., Mahrus, S., McCall, B., Pirzkall, A., Munn, D. H., Janik, J. E. & 1 others, Khleif, S. N., Jun 20 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 61.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Kynurenine
Half-Life
Neoplasms
Tryptophan
4 Citations (Scopus)

The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease

McDonald-Hyman, C., Muller, J. T., Loschi, M., Thangavelu, G., Saha, A., Kumari, S., Reichenbach, D. K., Smith, M. J., Zhang, G., Koehn, B. H., Lin, J., Mitchell, J. S., Fife, B. T., Panoskaltsis-Mortari, A., Feser, C. J., Kirchmeier, A. K., Osborn, M. J., Hippen, K. L., Kelekar, A., Serody, J. S. & 6 others, Turka, L. A., Munn, D. H., Chi, H., Neubert, T. A., Dustin, M. L. & Blazar, B. R., Oct 1 2018, In : Journal of Clinical Investigation. 128, 10, p. 4604-4621 18 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Graft vs Host Disease
Vimentin
Regulatory T-Lymphocytes
Protein Kinase C
2017
2 Citations (Scopus)

Adjuvant IL-7 potentiates adoptive T cell therapy by amplifying and sustaining polyfunctional antitumor CD4+ T cells

Ding, Z-C., Habtetsion, T., Cao, Y., Li, T., Liu, C., Kuczma, M., Chen, T., Hao, Z., Bryan, L. J., Munn, D. H. & Zhou, G., Dec 1 2017, In : Scientific Reports. 7, 1, 12168.

Research output: Contribution to journalArticle

Interleukin-7
Cell- and Tissue-Based Therapy
T-Lymphocytes
Cytokines
Adoptive Immunotherapy
7 Citations (Scopus)

A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression

Mangaonkar, A., Mondal, A. K., Fulzule, S., Pundkar, C., Park, E. J., Jillella, A., Kota, V., Xu, H., Savage, N. M., Shi, H., Munn, D. & Kolhe, R., Dec 1 2017, In : Scientific Reports. 7, 1, 12892.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Acute Myeloid Leukemia
Mortality
Messenger RNA
Bone Marrow
5 Citations (Scopus)

Development and evaluation of two abbreviated questionnaires for mentoring and research self-efficacy

Jeffe, D. B., Rice, T. K., Boyington, J. E. A., Rao, D. C., Jean-Louis, G., Dávila-Román, V. G., Taylor, A. L., Pace, B. S. & Boutjdir, M., Mar 1 2017, In : Ethnicity and Disease. 27, 2, p. 179-188 10 p.

Research output: Contribution to journalArticle

Self Efficacy
Mentors
Research
Equipment and Supplies
Publications
7 Citations (Scopus)

Early career mentoring through the American Society of Pediatric Hematology/Oncology: Lessons learned from a pilot program

Badawy, S. M., Black, V., Meier, E. R., Myers, K. C., Pinkney, K., Hastings, C., Hilden, J. M., Zweidler-McKay, P., Stork, L. C., Johnson, T. S. & Vaiselbuh, S. R., Mar 1 2017, In : Pediatric Blood and Cancer. 64, 3, e26252.

Research output: Contribution to journalArticle

Mentors
Hematology
Pediatrics
Program Evaluation
Postal Service
10 Citations (Scopus)

In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines

Hippen, K. L., O'Connor, R. S., Lemire, A. M., Saha, A., Hanse, E. A., Tennis, N. C., Merkel, S. C., Kelekar, A., Riley, J. L., Levine, B. L., June, C. H., Turka, L. A., Kean, L. S., MacMillan, M. L., Miller, J. S., Wagner, J. E., Munn, D. H. & Blazar, B. R., Dec 2017, In : American Journal of Transplantation. 17, 12, p. 3098-3113 16 p.

Research output: Contribution to journalArticle

Kynurenine
Regulatory T-Lymphocytes
Tryptophan
Graft vs Host Disease
Interleukin-2
3 Citations (Scopus)

Mentored training to increase diversity among faculty in the biomedical sciences: The NHL BI Summer Institute Programs to Increase Diversity (SI PID ) and the Programs to Increase Diversity among Individuals Engaged in Health-related Research (PRIDE )

Rice, T. K., Jeffe, D. B., Boyington, J. E. A., Jobe, J. B., Dávila-Román, V. G., Gonzalez, J. E., De Las Fuentes, L., Makala, L. H. C., Sarkar, R., Ogedegbe, G. G., Taylor, A. L., Czajkowski, S., Rao, D. C., Pace, B. S., Jean-Louis, G. & Boutjdir, M., Jun 1 2017, In : Ethnicity and Disease. 27, 3, p. 249-256 8 p.

Research output: Contribution to journalArticle

Health
Research
Hispanic Americans
Research Personnel
Education
2 Citations (Scopus)

Newly Characterized Murine Undifferentiated Sarcoma Models Sensitive to Virotherapy with Oncolytic HSV-1 M002

Ring, E. K., Li, R., Moore, B. P., Nan, L., Kelly, V. M., Han, X., Beierle, E. A., Markert, J. M., Leavenworth, J. W., Gillespie, G. Y. & Friedman, G. K., Dec 15 2017, In : Molecular Therapy - Oncolytics. 7, p. 27-36 10 p.

Research output: Contribution to journalArticle

Oncolytic Viruses
Human Herpesvirus 1
Sarcoma
Interleukin-12
Immune System
8 Citations (Scopus)

Promoter methylation modulates indoleamine 2,3-dioxygenase 1 induction by activated T cells in human breast cancers

Noonepalle, S. K., Gu, F., Lee, E. J., Choi, J. H., Han, Q., Kim, J., Ouzounova, M., Shull, A. Y., Pei, L., Hsu, P. Y., Kolhe, R., Shi, F., Choi, J., Chiou, K., Huang, T. H. M., Korkaya, H., Deng, L., Xin, H. B., Huang, S., Thangaraju, M. & 5 others, Sreekumar, A., Ambs, S., Tang, S. C., Munn, D. H. & Shi, H., Apr 2017, In : Cancer Immunology Research. 5, 4, p. 330-344 15 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Methylation
Triple Negative Breast Neoplasms
Breast Neoplasms
T-Lymphocytes
1 Citation (Scopus)

Stroke in a child with hemoglobin SC disease: A case report describing use of hydroxyurea after transfusion therapy

Fridlyand, D., Wilder, C., Clay, E. L. J., Gilbert, B. & Pace, B. S., Jan 1 2017, In : Pediatric Reports. 9, 1, 6984.

Research output: Contribution to journalArticle

Hemoglobin SC Disease
Hydroxyurea
Stroke
Fetal Hemoglobin
Cerebral Infarction

TFE3-positive renal cell carcinoma occurring in three children with dysfunctional kidneys on immunosuppression

Schaefer, B. A., Johnson, T. S., Hooper, D. K., Nathan, J. D. & Geller, J. I., Jun 1 2017, In : Pediatric Transplantation. 21, 4, e12912.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Immunosuppression
Pediatrics
Kidney
Chronic Renal Insufficiency
2016
4 Citations (Scopus)

Activation of Fetal γ-globin Gene Expression via Direct Protein Delivery of Synthetic Zinc-finger DNA-Binding Domains

Hossain, M. A., Shen, Y., Knudson, I., Thakur, S., Stees, J. R., Qiu, Y., Pace, B. S., Peterson, K. R. & Bungert, J., Jan 1 2016, In : Molecular Therapy - Nucleic Acids. 5, p. e378

Research output: Contribution to journalArticle

Globins
Zinc Fingers
Gene Expression
DNA
Fetal Hemoglobin
4 Citations (Scopus)

Biomechanical and biochemical regulation of cathepsin K expression in endothelial cells converge at AP-1 and NF-κB

Keegan, P. M., Anbazhakan, S., Kang, B., Pace, B. S. & Platt, M. O., May 1 2016, In : Biological Chemistry. 397, 5, p. 459-468 10 p.

Research output: Contribution to journalArticle

Cathepsin K
Endothelial cells
Transcription Factor AP-1
Endothelial Cells
Shear stress
17 Citations (Scopus)

Deletion of LRP5 and LRP6 in dendritic cells enhances antitumor immunity

Hong, Y., Manoharan, I., Suryawanshi, A., Shanmugam, A., Swafford, D., Ahmad, S., Chinnadurai, R., Manicassamy, B., He, Y., Mellor, A. L., Thangaraju, M., Munn, D. H. & Manicassamy, S., Apr 2 2016, In : OncoImmunology. 5, 4

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-6
Low Density Lipoprotein Receptor-Related Protein-5
Dendritic Cells
Immunity
Tumor Microenvironment
7 Citations (Scopus)

IL-7 signaling imparts polyfunctionality and stemness potential to CD4+ T cells

Ding, Z-C., Liu, C., Cao, Y., Habtetsion, T., Kuczma, M., Pi, W., Kong, H., Cacan, E., Greer, S. F., Cui, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Jun 2 2016, In : OncoImmunology. 5, 6, e1171445.

Research output: Contribution to journalArticle

Interleukin-7
T-Lymphocytes
Aptitude
Immunotherapy
Neoplasms
9 Citations (Scopus)

Minireview: Multiomic candidate biomarkers for clinical manifestations of sickle cell severity: Early steps to precision medicine

Goodman, S. R., Pace, B. S., Hansen, K. C., D’alessandro, A., Xia, Y., Daescu, O. & Glatt, S. J., Jan 1 2016, In : Experimental Biology and Medicine. 241, 7, p. 772-781 10 p.

Research output: Contribution to journalArticle

Precision Medicine
Biomarkers
Medicine
Sickle Cell Anemia
Retrospective Studies
17 Citations (Scopus)

MiR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency

Lu, Y., Hippen, K. L., Lemire, A. L., Gu, J., Wang, W., Ni, X., Ranganathan, P., Levine, B. L., Riley, J. L., June, C. H., Turka, L. A., Munn, D. H., Garzon, R., Lu, L. & Blazar, B. R., Sep 8 2016, In : Blood. 128, 10, p. 1424-1435 12 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Graft vs Host Disease
MicroRNAs
T-cells
Grafts
7 Citations (Scopus)

Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease

Liu, L., Pertsemlidis, A., Ding, L. H., Story, M. D., Steinberg, M. H., Sebastiani, P., Hoppe, C., Ballas, S. K. & Pace, B. S., Jan 1 2016, In : Experimental Biology and Medicine. 241, 7, p. 706-718 13 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
Genome-Wide Association Study
Sickle Cell Anemia
Single Nucleotide Polymorphism
7 Citations (Scopus)

Original Research: Stable expression of miR-34a mediates fetal hemoglobin induction in K562 cells

Ward, C. M., Li, B. & Pace, B. S., Jan 1 2016, In : Experimental Biology and Medicine. 241, 7, p. 719-729 11 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
K562 Cells
Genes
Histone Deacetylase 1
38 Citations (Scopus)

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality

Saha, A., O'Connor, R. S., Thangavelu, G., Lovitch, S. B., Dandamudi, D. B., Wilson, C. B., Vincent, B. G., Tkachev, V., Pawlicki, J. M., Furlan, S. N., Kean, L. S., Aoyama, K., Taylor, P. A., Panoskaltsis-Mortari, A., Foncea, R., Ranganathan, P., Devine, S. M., Burrill, J. S., Guo, L., Sacristan, C. & 15 others, Snyder, N. W., Blair, I. A., Milone, M. C., Dustin, M. L., Riley, J. L., Bernlohr, D. A., Murphy, W. J., Fife, B. T., Munn, D. H., Miller, J. S., Serody, J. S., Freeman, G. J., Sharpe, A. H., Turka, L. A. & Blazar, B. R., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2642-2660 19 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Tissue Donors
Ligands
T-Lymphocytes
Transplants
1 Citation (Scopus)

Sickle cell disease severity: an introduction

Pace, B. S. & Goodman, S. R., Jan 1 2016, In : Experimental Biology and Medicine. 241, 7, p. 677-678 2 p.

Research output: Contribution to journalArticle

Sickle Hemoglobin
Fetal Hemoglobin
Hydroxyurea
Biomarkers
63 Citations (Scopus)

STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation

Lemos, H., Mohamed, E., Huang, L., Ou, R., Pacholczyk, G., Arbab, A. S., Munn, D. & Mellor, A. L., Apr 15 2016, In : Cancer Research. 76, 8, p. 2076-2081 6 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Interferons
Growth
Lewis Lung Carcinoma
Genes
38 Citations (Scopus)

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

Flynn, R., Paz, K., Du, J., Reichenbach, D. K., Taylor, P. A., Panoskaltsis-Mortari, A., Vulic, A., Luznik, L., MacDonald, K. K. P., Hill, G. R., Nyuydzefe, M. S., Weiss, J. M., Chen, W., Trzeciak, A., Serody, J. S., Aguilar, E. G., Murphy, W. J., Maillard, I., Munn, D. H., Koreth, J. & 6 others, Cutler, C. S., Antin, J. H., Ritz, J., Waksal, S. D., Zanin-Zhorov, A. & Blazar, B. R., Apr 28 2016, In : Blood. 127, 17, p. 2144-2154 11 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Graft vs Host Disease
Grafts
STAT3 Transcription Factor
Interleukin-17
37 Citations (Scopus)

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner

McDonald-Hyman, C., Flynn, R., Panoskaltsis-Mortari, A., Peterson, N., MacDonald, K. P. A., Hill, G. R., Luznik, L., Serody, J. S., Murphy, W. J., Maillard, I., Munn, D. H., Turka, L. A., Koreth, J., Cutler, C. S., Soiffer, R. J., Antin, J. H., Ritz, J. & Blazar, B. R., Aug 18 2016, In : Blood. 128, 7, p. 1013-1017 5 p.

Research output: Contribution to journalArticle

T-cells
Adoptive Transfer
Graft vs Host Disease
Regulatory T-Lymphocytes
Grafts
14 Citations (Scopus)

Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase

Huang, L., Ou, R., Rabelo de Souza, G., Cunha, T. M., Lemos, H., Mohamed, E., Li, L., Pacholczyk, G., Randall, J., Munn, D. H. & Mellor, A. L., May 1 2016, In : PLoS Pathogens. 12, 5, e1005615.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Virus Diseases
Retroviridae Infections
Hypersensitivity
Leukemia
2015
28 Citations (Scopus)

B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality

Veenstra, R. G., Flynn, R., Kreymborg, K., McDonald-Hyman, C., Saha, A., Taylor, P. A., Osborn, M. J., Panoskaltsis-Mortari, A., Schmitt-Graeff, A., Lieberknecht, E., Murphy, W. J., Serody, J. S., Munn, D. H., Freeman, G. J., Allison, J. P., Mak, T. W., Van Brink, M. D., Zeiser, R. & Blazar, B. R., Jan 1 2015, In : Blood. 125, 21, p. 3335-3346 12 p.

Research output: Contribution to journalArticle

T-cells
Graft vs Host Disease
Grafts
T-Lymphocytes
Transplants
50 Citations (Scopus)

Canonical Wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation

Suryawanshi, A., Manoharan, I., Hong, Y., Swafford, D., Majumdar, T., Taketo, M. M., Manicassamy, B., Koni, P. A., Thangaraju, M., Sun, Z., Mellor, A. L., Munn, D. H. & Manicassamy, S., Apr 1 2015, In : Journal of Immunology. 194, 7, p. 3295-3304 10 p.

Research output: Contribution to journalArticle

Autoimmunity
Dendritic Cells
Catenins
Autoimmune Experimental Encephalomyelitis
Low Density Lipoprotein Receptor-Related Protein-6
13 Citations (Scopus)

Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease

Pace, B. S., Liu, L., Li, B. & Makala, L. H., Jan 1 2015, In : Experimental Biology and Medicine. 240, 8, p. 1050-1064 15 p.

Research output: Contribution to journalArticle

Cell signaling
Fetal Hemoglobin
Sickle Cell Anemia
Globins
Sickle Hemoglobin
20 Citations (Scopus)

Changes in the amino acid sequence of the recombinant human factor VIIa analog, vatreptacog alfa, are associated with clinical immunogenicity

Mahlangu, J. N., Weldingh, K. N., Lentz, S. R., Kaicker, S., Karim, F. A., Matsushita, T., Recht, M., Tomczak, W., Windyga, J., Ehrenforth, S., Knobe, K., Weltermann, A., de Paula, E., Cerqueira, M., Zupancic-Salek, S., Katsarou, O., Economou, M., Nemes, L., Boda, Z., Santagostino, E. & 22 others, Tagariello, G., Hanabusa, H., Fukutake, K., Shima, M., Serban, M., Elezo-vic, I., Savic, A., Shen, M., Chuansumrit, A., Angchaisuksiri, P., Kavakli, K., Sasmaz, I., Madan, B., Giangrande, P., Kempton, C., Young, G., Quon, D., Ameri, A., Kuriakose, P., Obzut, D., Wang, M. & Ortiz, I., Nov 1 2015, In : Journal of Thrombosis and Haemostasis. 13, 11, p. 1989-1998 10 p.

Research output: Contribution to journalArticle

Amino Acid Sequence
Anti-Idiotypic Antibodies
Hemophilia A
Pharmaceutical Preparations
Epitope Mapping
26 Citations (Scopus)
Acetylation
Histones
Ethanol
Cytoskeleton
Memory Disorders
41 Citations (Scopus)

GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells

Koehn, B. H., Apostolova, P., Haverkamp, J. M., Miller, J. S., McCullar, V., Tolar, J., Munn, D. H., Murphy, W. J., Brickey, W. J., Serody, J. S., Gabrilovich, D. I., Bronte, V., Murray, P. J., Ting, J. P. Y., Zeiser, R. & Blazar, B. R., Sep 24 2015, In : Blood. 126, 13, p. 1621-1628 8 p.

Research output: Contribution to journalArticle

Inflammasomes
Graft vs Host Disease
Grafts
Myeloid-Derived Suppressor Cells
Bone
9 Citations (Scopus)

Implementation of transcranial Doppler ultrasonography screening and primary stroke prevention in urban and rural sickle cell disease populations

Hussain, S., Nichols, F., Bowman, L., Xu, H. & Neunert, C., Feb 1 2015, In : Pediatric Blood and Cancer. 62, 2, p. 219-223 5 p.

Research output: Contribution to journalArticle

Doppler Transcranial Ultrasonography
Sickle Cell Anemia
Primary Prevention
Stroke
Standard of Care
7 Citations (Scopus)

Novel inducers of fetal globin identified through high throughput screening (HTS) are active in vivo in anemic baboons and transgenic mice

Boosalis, M. S., Sangerman, J. I., White, G. L., Wolf, R. F., Shen, L., Dai, Y., White, E., Makala, L. H., Li, B., Pace, B. S., Nouraie, M., Faller, D. V. & Perrine, S. P., Dec 1 2015, In : PloS one. 10, 12, 0144660.

Research output: Contribution to journalArticle

Globins
Papio
Transgenic Mice
Screening
promoter regions
46 Citations (Scopus)

RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis

Zhang, M., Zhu, X., Zhang, Y., Cai, Y., Chen, J., Sivaprakasam, S., Gurav, A., Pi, W., Makala, L. H., Wu, J., Pace, B. S., Tuan Lo, D., Ganapathy, V., Singh, N. & Li, H., Dec 1 2015, In : Cell Death and Differentiation. 22, 12, p. 1922-1934 13 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Hematopoiesis
Hematopoietic Stem Cells
Unfolded Protein Response
Proteins
87 Citations (Scopus)

Severe bleeding events in adults and children with primary immune thrombocytopenia: A systematic review

Neunert, C., Noroozi, N., Norman, G., Buchanan, G. R., Goy, J., Nazi, I., Kelton, J. G. & Arnold, D. M., Mar 1 2015, In : Journal of Thrombosis and Haemostasis. 13, 3, p. 457-464 8 p.

Research output: Contribution to journalArticle

Idiopathic Thrombocytopenic Purpura
Hemorrhage
Confidence Intervals
Cerebral Hemorrhage
Reproducibility of Results

The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells

Sharma, M. D., Shinde, R., McGaha, T. L., Huang, L., Holmgaard, R., Wolchok, J., Mautino, M., Celis, E., Sharpe, A., Francisco, L., Powell, J., Yagita, H., Mellor, A. L., Blazar, B. & Munn, D. H., Jan 1 2015, In : Journal for ImmunoTherapy of Cancer. 3, O19.

Research output: Contribution to journalArticle

Tumor Microenvironment
Immunosuppressive Agents
143 Citations (Scopus)

Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner

Holmgaard, R. B., Zamarin, D., Li, Y., Gasmi, B., Munn, D. H., Allison, J. P., Merghoub, T. & Wolchok, J. D., Oct 13 2015, In : Cell Reports. 13, 2, p. 412-424 13 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumors
Neoplasms
T-cells
Immunosuppressive Agents
42 Citations (Scopus)

UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development

Cai, Y., Pi, W., Sivaprakasam, S., Zhu, X., Zhang, M., Chen, J., Makala, L. H., Lu, C., Wu, J., Teng, Y., Pace, B. S., Tuan Lo, D., Singh, N. & Li, H., Nov 2015, In : PLoS Genetics. 11, 11, e1005643.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
endoplasmic reticulum
Embryonic Development
Hematopoiesis
Hematopoietic Stem Cells