David C Hess

EVP, Med Affairs & Dean, MCG

  • 10585 Citations
  • 57 h-Index
1989 …2019
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Research Output 1989 2019

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Article
2019

Impact of Participation in a Telestroke Network on Clinical Outcomes

Zhang, D., Shi, L., Ido, M. S., Green, D. E., Li, Y., Su, D. & Hess, D. C., Jan 1 2019, In : Circulation. Cardiovascular quality and outcomes. 12, 1, p. e005147

Research output: Contribution to journalArticle

Stroke
Tissue Plasminogen Activator
Propensity Score
Observational Studies
Hospital Bed Capacity
2018
6 Citations (Scopus)

Chronic Remote Ischemic Conditioning Is Cerebroprotective and Induces Vascular Remodeling in a VCID Model

Khan, M. B., Hafez, S., Hoda, MD. N., Baban, B., Wagner, J., Awad, M. E., Sangabathula, H., Haigh, S., Elsalanty, M. E., Waller, J. L. & Hess, D. C., Feb 1 2018, In : Translational Stroke Research. 9, 1, p. 51-63 13 p.

Research output: Contribution to journalArticle

Carotid Stenosis
Cerebrovascular Circulation
Blood Vessels
Dementia
Myelin Basic Protein
2 Citations (Scopus)

Expansion of telestroke services improves quality of care provided in super rural areas

Zhang, D., Wang, G., Zhu, W., Thapa, J. R., Switzer, J. A., Hess, D. C., Smith, M. L. & Ritchey, M. D., Dec 1 2018, In : Health Affairs. 37, 12, p. 2005-2013 9 p.

Research output: Contribution to journalArticle

Quality of Health Care
Tissue Plasminogen Activator
Stroke
Thrombectomy
Fee-for-Service Plans
16 Citations (Scopus)

Human neural stem cell extracellular vesicles improve recovery in a porcine model of ischemic stroke

Webb, R. L., Kaiser, E. E., Jurgielewicz, B. J., Spellicy, S., Scoville, S. L., Thompson, T. A., Swetenburg, R. L., Hess, D. C., West, F. D. & Stice, S. L., Jan 1 2018, In : Stroke. 49, 5, p. 1248-1256 9 p.

Research output: Contribution to journalArticle

Open Access
Neural Stem Cells
Swine
Middle Cerebral Artery Infarction
Stroke
Gait
13 Citations (Scopus)

Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model

Webb, R. L., Kaiser, E. E., Scoville, S. L., Thompson, T. A., Fatima, S., Pandya, C. D., Sriram, K., Swetenburg, R. L., Vaibhav, K., Arbab, A. S., Baban, B., Dhandapani, K. M., Hess, D. C., Hoda, MD. N. & Stice, S. L., Oct 1 2018, In : Translational Stroke Research. 9, 5, p. 530-539 10 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stroke
Rodentia
Mesenchymal Stromal Cells
Extracellular Vesicles
4 Citations (Scopus)

Remote ischemic post-conditioning promotes hematoma resolution via AMPK-dependent immune regulation

Vaibhav, K., Braun, M., Khan, M. B., Fatima, S., Saad, N., Shankar, A., Khan, Z. T., Harris, R. B., Yang, Q., Huo, Y., Arbab, A. S., Giri, S., Alleyne, C. H., Vender, J. R., Hess, D. C., Baban, B., Hoda, MD. N. & Dhandapani, K. M., Oct 1 2018, In : The Journal of experimental medicine. 215, 10, p. 2636-2654 19 p.

Research output: Contribution to journalArticle

Ischemic Postconditioning
AMP-Activated Protein Kinases
Hematoma
Extremities
Cerebral Hemorrhage
5 Citations (Scopus)

Selective activation of cannabinoid receptor-2 reduces neuroinflammation after traumatic brain injury via alternative macrophage polarization

Braun, M., Khan, Z. T., Khan, M. B., Kumar, M., Ward, A., Achyut, B. R., Arbab, A. S., Hess, D. C., Hoda, MD. N., Baban, B., Dhandapani, K. M. & Vaibhav, K., Feb 1 2018, In : Brain, Behavior, and Immunity. 68, p. 224-237 14 p.

Research output: Contribution to journalArticle

Cannabinoid Receptors
Macrophages
Endocannabinoids
Cerebrovascular Circulation
Anti-Inflammatory Agents
2017
3 Citations (Scopus)

Collaterals 2016: Translating the collaterome around the globe

for the Collaterals 2016 Consortium, Jan 1 2017, In : International Journal of Stroke. 12, 4, p. 338-342 5 p.

Research output: Contribution to journalArticle

Stroke
Videoconferencing
Collateral Circulation
Precision Medicine
Triage
21 Citations (Scopus)

Induced Pluripotent Stem Cell-Derived Neural Stem Cell Therapy Enhances Recovery in an Ischemic Stroke Pig Model

Baker, E. W., Platt, S. R., Lau, V. W., Grace, H. E., Holmes, S. P., Wang, L., Duberstein, K. J., Howerth, E. W., Kinder, H. A., Stice, S. L., Hess, D. C., Mao, H. & West, F. D., Dec 1 2017, In : Scientific Reports. 7, 1, 10075.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Neural Stem Cells
Cell- and Tissue-Based Therapy
Swine
Stroke
12 Citations (Scopus)

Minocycline in acute cerebral hemorrhage an early phase randomized trial

Fouda, A. Y., Newsome, A. S., Spellicy, S., Waller, J. L., Zhi, W., Hess, D. C., Ergul, A., Edwards, D. J., Fagan, S. C. & Switzer, J. A., Oct 1 2017, In : Stroke. 48, 10, p. 2885-2887 3 p.

Research output: Contribution to journalArticle

Minocycline
Cerebral Hemorrhage
Half-Life
Anti-Inflammatory Agents
Pharmacokinetics
64 Citations (Scopus)

Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial

Hess, D. C., Wechsler, L. R., Clark, W. M., Savitz, S. I., Ford, G. A., Chiu, D., Yavagal, D. R., Uchino, K., Liebeskind, D. S., Auchus, A. P., Sen, S., Sila, C. A., Vest, J. D. & Mays, R. W., May 1 2017, In : The Lancet Neurology. 16, 5, p. 360-368 9 p.

Research output: Contribution to journalArticle

Stem Cells
Stroke
Placebos
Safety
National Institutes of Health (U.S.)
58 Citations (Scopus)

Telemedicine quality and outcomes in stroke: A scientific statement for healthcare professionals from the American Heart Association/American Stroke Association

Wechsler, L. R., Demaerschalk, B. M., Schwamm, L. H., Adeoye, O. M., Audebert, H. J., Fanale, C. V., Hess, D. C., Majersik, J. J., Nystrom, K. V., Reeves, M. J., Rosamond, W. D. & Switzer, J. A., Jan 1 2017, In : Stroke. 48, 1, p. e3-e25

Research output: Contribution to journalArticle

Telemedicine
Committee Membership
Stroke
Delivery of Health Care
Credentialing
2016
2 Citations (Scopus)

Addressing Disparities in Stroke Prevention for Atrial Fibrillation: Educational Opportunities

Karcher, R., Berman, A. E., Gross, H., Hess, D. C., Jauch, E. C., Viser, P. E., Solenski, N. J. & Wolf, A. M. D., Jul 1 2016, In : American Journal of Medical Quality. 31, 4, p. 337-348 12 p.

Research output: Contribution to journalArticle

Atrial Fibrillation
Stroke
Anticoagulants
Communication
Cultural Competency
3 Citations (Scopus)

Stroke Treatment Academic Industry Roundtable Recommendations for Individual Data Pooling Analyses in Stroke

STAIR IX Collaborators, Aug 1 2016, In : Stroke. 47, 8, p. 2154-2159 6 p.

Research output: Contribution to journalArticle

Meta-Analysis
Industry
Stroke
Clinical Trials
Authorship
2015
4 Citations (Scopus)

Telestroke: Variations in intravenous thrombolysis by spoke hospitals

Switzer, J. A., Singh, R., Mathiassen, L., Waller, J. L., Adams, R. J. & Hess, D. C., Jan 1 2015, In : Journal of Stroke and Cerebrovascular Diseases. 24, 4, p. 739-744 6 p.

Research output: Contribution to journalArticle

Tissue Plasminogen Activator
Stroke
Hospital Emergency Service
Nurses
Health Facility Size
2014
13 Citations (Scopus)
Minocycline
Stroke
Cerebrovascular Circulation
Tissue Plasminogen Activator
Therapeutics
59 Citations (Scopus)

A double-blind placebo-controlled clinical evaluation of MultiStem for the treatment of ischemic stroke

Hess, D. C., Sila, C. A., Furlan, A. J., Wechsler, L. R., Switzer, J. A. & Mays, R. W., Jan 1 2014, In : International Journal of Stroke. 9, 3, p. 381-386 6 p.

Research output: Contribution to journalArticle

Stroke
Placebos
Therapeutics
Neurological Models
Clinical Trials
20 Citations (Scopus)

Development and characterization of a Yucatan miniature biomedical pig permanent middle cerebral artery occlusion stroke model

Platt, S. R., Holmes, S. P., Howerth, E. W., Duberstein, K. J. J., Dove, C. R., Kinder, H. A., Wyatt, E. L., Linville, A. V., Lau, V. W., Stice, S. L., Hill, W. D., Hess, D. C. & West, F. D., Mar 23 2014, In : Experimental and Translational Stroke Medicine. 6, 1, 5.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Swine
Stroke
Brain
Animal Models
20 Citations (Scopus)

Gait analysis in a pre- and post-ischemic stroke biomedical pig model

Duberstein, K. J., Platt, S. R., Holmes, S. P., Dove, C. R., Howerth, E. W., Kent, M., Stice, S. L., Hill, W. D., Hess, D. C. & West, F. D., Feb 10 2014, In : Physiology and Behavior. 125, p. 8-16 9 p.

Research output: Contribution to journalArticle

Gait
Swine
Stroke
Middle Cerebral Artery Infarction
Hindlimb
45 Citations (Scopus)

Rapamycin up-regulation of autophagy reduces infarct size and improves outcomes in both permanent MCAL, and embolic MCAO, murine models of stroke

Buckley, K. M., Hess, D. L., Sazonova, I. Y., Periyasamy Thandavan, S., Barrett, J. R., Kirks, R., Grace, H., Kondrikova, G., Johnson, M. H., Hess, D. C., Schoenlein, P. V., Hoda, MD. N. & Hill, W. D., Jun 21 2014, In : Experimental and Translational Stroke Medicine. 6, 1, 8.

Research output: Contribution to journalArticle

Autophagy
Middle Cerebral Artery
Sirolimus
Ligation
Up-Regulation
22 Citations (Scopus)

Remote Ischemic Perconditioning is Effective After Embolic Stroke in Ovariectomized Female Mice

Hoda, MD. N., Bhatia, K., Hafez, S. S., Johnson, M. H., Siddiqui, S., Ergul, A., Zaidi, S. K., Fagan, S. C. & Hess, D. C., Aug 1 2014, In : Translational Stroke Research. 5, 4, p. 484-490 7 p.

Research output: Contribution to journalArticle

Stroke
Tissue Plasminogen Activator
Cerebrovascular Circulation
Infarction
Hemorrhage
41 Citations (Scopus)

Remote Ischemic Postconditioning: Harnessing Endogenous Protection in a Murine Model of Vascular Cognitive Impairment

Khan, M. B., Hoda, MD. N., Vaibhav, K., Giri, S., Wang, L., Waller, J. L., Ergul, A., Dhandapani, K. M., Fagan, S. C. & Hess, D. C., Jan 1 2014, In : Translational Stroke Research. 6, 1, p. 69-77 9 p.

Research output: Contribution to journalArticle

Ischemic Postconditioning
Carotid Stenosis
Cerebrovascular Circulation
Blood Vessels
Cognition
2013
21 Citations (Scopus)

Minocycline repurposing in critical illness: Focus on stroke

Liao, T. V., Forehand, C. C., Hess, D. C. & Fagan, S. C., Nov 25 2013, In : Current Topics in Medicinal Chemistry. 13, 18, p. 2283-2290 8 p.

Research output: Contribution to journalArticle

Minocycline
Critical Illness
Stroke
Vascular System Injuries
Thrombolytic Therapy
Basilar Artery
Angiography
Tomography
Dysarthria
Vertigo
8 Citations (Scopus)

Simplified modified Rankin Scale questionnaire correlates with stroke severity

Bruno, A., Close, B., Switzer, J. A., Hess, D. C., Gross, H., Nichols, F. T. & Akinwuntan, A. E., Aug 1 2013, In : Clinical Rehabilitation. 27, 8, p. 724-727 4 p.

Research output: Contribution to journalArticle

Stroke
National Institutes of Health (U.S.)
Registries
Surveys and Questionnaires
Hospital Departments
10 Citations (Scopus)

Timeliness of intravenous thrombolysis via telestroke in Georgia

Bruno, A., Lanning, K. M., Gross, H., Hess, D. C., Nichols, F. T. & Switzer, J. A., Sep 1 2013, In : Stroke. 44, 9, p. 2620-2622 3 p.

Research output: Contribution to journalArticle

Hospital Emergency Service
Stroke
Referral and Consultation
Communication
Head
2012
43 Citations (Scopus)

A simple, assumption-free, and clinically interpretable approach for analysis of modified Rankin outcomes

Howard, G., Waller, J. L., Voeks, J. H., Howard, V. J., Jauch, E. C., Lees, K. R., Nichols, F. T., Rahlfs, V. W. & Hess, D. C., Mar 1 2012, In : Stroke. 43, 3, p. 664-669 6 p.

Research output: Contribution to journalArticle

Nonparametric Statistics
Investigational Therapies
Therapeutics
Random Allocation
Stroke
2 Citations (Scopus)

Impact of primary stroke center certification on location of acute ischemic stroke care in Georgia

Switzer, J. A., Akinwuntan, A. E., Waller, J. L., Nichols, F. T., Hess, D. C. & Bruno, A., May 1 2012, In : Stroke. 43, 5, p. 1415-1417 3 p.

Research output: Contribution to journalArticle

Certification
Stroke
16 Citations (Scopus)

Minocycline Prevents IL-6 Increase after Acute Ischemic Stroke

Switzer, J. A., Sikora, A., Ergul, A., Waller, J. L., Hess, D. C. & Fagan, S. C., Sep 1 2012, In : Translational Stroke Research. 3, 3, p. 364-368 5 p.

Research output: Contribution to journalArticle

Minocycline
Interleukin-6
Stroke
Nervous System
Anti-Inflammatory Agents
62 Citations (Scopus)

Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke

Hoda, MD. N., Siddiqui, S., Herberg, S., Periyasamy Thandavan, S., Bhatia, K., Hafez, S. S., Johnson, M. H., Hill, W. D., Ergul, A., Fagan, S. C. & Hess, D. C., Oct 1 2012, In : Stroke. 43, 10, p. 2794-2799 6 p.

Research output: Contribution to journalArticle

Tissue Plasminogen Activator
Stroke
Plasminogen Activators
Middle Cerebral Artery Infarction
Cerebrovascular Circulation
2011
10 Citations (Scopus)

Cell therapy for ischaemic stroke

Hess, D. C. & Hill, W. D., Apr 1 2011, In : Cell Proliferation. 44, SUPPL. 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Cell Transplantation
Cell- and Tissue-Based Therapy
Animal Models
Stroke
Clinical Trials
15 Citations (Scopus)
Dibucaine
neocortex
Neocortex
Depolarization
Rodentia

Impact of systems of care and blood pressure management on stroke outcomes

Shulkin, D. J., Jewell, K. E., Alexandrov, A. W., Bernard, D. B., Brophy, G. M., Hess, D. C., Kohlbrenner, J., Martin-Schild, S., Mayer, S. A., Peacock, W. F., Qureshi, A. I., Sung, G. Y. & Lyles, A., Dec 1 2011, In : Population Health Management. 14, 6, p. 267-275 9 p.

Research output: Contribution to journalArticle

Stroke
Blood Pressure
Tissue Plasminogen Activator
Quality of Health Care
Triage
66 Citations (Scopus)

Matrix metalloproteinase-9 in an exploratory trial of intravenous minocycline for acute ischemic stroke

Switzer, J. A., Hess, D. C., Ergul, A., Waller, J. L., MacHado, L. S., Portik-Dobos, V., Pettigrew, L. C., Clark, W. M. & Fagan, S. C., Sep 1 2011, In : Stroke. 42, 9, p. 2633-2635 3 p.

Research output: Contribution to journalArticle

Minocycline
Matrix Metalloproteinase 9
Stroke
Plasminogen Activators
Thrombolytic Therapy
57 Citations (Scopus)

Minocycline Development for Acute Ischemic Stroke

Fagan, S. C., Cronic, L. E. & Hess, D. C., Jun 1 2011, In : Translational Stroke Research. 2, 2, p. 202-208 7 p.

Research output: Contribution to journalArticle

Minocycline
Stroke
Clinical Trials
Neuroprotective Agents
Tissue Plasminogen Activator
4 Citations (Scopus)

Recent advances in basic and translational stroke research

Boltze, J., Kranz, A., Wagner, D. C., Reymann, K., Reiser, G. & Hess, D. C., Feb 1 2011, In : Expert Review of Neurotherapeutics. 11, 2, p. 199-202 4 p.

Research output: Contribution to journalArticle

Translational Medical Research
Stroke
Cell- and Tissue-Based Therapy
Regeneration
Research
41 Citations (Scopus)

Sex-independent neuroprotection with minocycline after experimental thromboembolic stroke

Hoda, MD. N., Li, W., Ahmad, A., Ogbi, S., Zemskova, M. A., Johnson, M. H., Ergul, A., Hill, W. D., Hess, D. C. & Sazonova, I. Y., Dec 16 2011, In : Experimental and Translational Stroke Medicine. 3, 1, 16.

Research output: Contribution to journalArticle

Minocycline
Stroke
Matrix Metalloproteinases
Cerebrovascular Circulation
Neuroprotection
89 Citations (Scopus)

Simplified modified rankin scale questionnaire: Reproducibility over the telephone and validation with quality of life

Bruno, A., Akinwuntan, A. E., Lin, C., Close, B., Davis, K., Baute, V., Aryal, T., Brooks, D., Hess, D. C., Switzer, J. A. & Nichols, F. T., Aug 1 2011, In : Stroke. 42, 8, p. 2276-2279 4 p.

Research output: Contribution to journalArticle

Telephone
Quality of Life
Stroke
Neurology
Reproducibility of Results
13 Citations (Scopus)
Aircraft
Telemedicine
Stroke
X Ray Tomography
Therapeutics
2 Citations (Scopus)

Wisdom and determination in the ongoing pursuit of the ever-elusive neuroprotective agent

Howard, G., Hess, D. C. & Howard, V. J., Jun 1 2011, In : Stroke. 42, 6, p. 1505-1506 2 p.

Research output: Contribution to journalArticle

Neuroprotective Agents
Stroke
2010
38 Citations (Scopus)

A telestroke network enhances recruitment into acute stroke clinical trials

Switzer, J. A., Hall, C. E., Close, B., Nichols, F. T., Gross, H., Bruno, A. & Hess, D. C., Mar 1 2010, In : Stroke. 41, 3, p. 566-569 4 p.

Research output: Contribution to journalArticle

Telemedicine
Stroke
Clinical Trials
Referral and Consultation
Pharmaceutical Preparations
24 Citations (Scopus)

Development of an allogeneic adherent stem cell therapy for treatment of ischemic stroke

Mays, R. W., Borlongan, C. V., Yasuhara, T., Hara, K., Maki, M., Carroll, J. E., Deans, R. J. & Hess, D. C., Jan 1 2010, In : Journal of Experimental Stroke and Translational Medicine. 3, 1, p. 34-46 13 p.

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
Stem Cells
Stroke
Wounds and Injuries
Therapeutics
75 Citations (Scopus)

Improving modified rankin scale assessment with a simplified questionnaire

Bruno, A., Shah, N., Lin, C., Close, B., Hess, D. C., Davis, K., Baute, V., Switzer, J. A., Waller, J. L. & Nichols, F. T., May 1 2010, In : Stroke. 41, 5, p. 1048-1050 3 p.

Research output: Contribution to journalArticle

Stroke
Ambulatory Care Facilities
Outcome Assessment (Health Care)
Interviews
Surveys and Questionnaires
144 Citations (Scopus)

Minocycline to Improve Neurologic Outcome in Stroke (MINOS): A dose-finding study

Fagan, S. C., Waller, J. L., Nichols, F. T., Edwards, D. J., Pettigrew, L. C., Clark, W. M., Hall, C. E., Switzer, J. A., Ergul, A. & Hess, D. C., Oct 1 2010, In : Stroke. 41, 10, p. 2283-2287 5 p.

Research output: Contribution to journalArticle

Minocycline
Nervous System
Stroke
Tissue Plasminogen Activator
Half-Life
8 Citations (Scopus)

Peri-hemorrhagic degeneration accompanies stereotaxic collagenase-mediated cortical hemorrhage in mouse

Masuda, T., Maki, M., Hara, K., Yasuhara, T., Matsukawa, N., Yu, S., Bae, E. C., Tajiri, N., Chheda, S. H., Solomita, M. A., Weinbren, N., Kaneko, Y., Kirov, S. A., Hess, D. C., Hida, H. & Borlongan, C. V., Oct 8 2010, In : Brain Research. 1355, p. 228-239 12 p.

Research output: Contribution to journalArticle

Collagenases
Hemorrhage
Cerebral Hemorrhage
Wounds and Injuries
Neurons
2009
3 Citations (Scopus)

Anomaly in aortic arch alters pathological outcome of transient global ischemia in Rhesus macaques

Hara, K., Yasuhara, T., Maki, M., Matsukawa, N., Yu, G., Xu, L., Tambrallo, L., Rodriguez, N. A., Stern, D. M., Yamashima, T., Buccafusco, J. J., Kawase, T., Hess, D. C. & Borlongan, C. V., Aug 25 2009, In : Brain Research. 1286, p. 185-191 7 p.

Research output: Contribution to journalArticle

Macaca mulatta
Thoracic Aorta
Ischemia
Arteries
Brachiocephalic Trunk
74 Citations (Scopus)
Hospital Emergency Service
Stroke
Thrombolytic Therapy
Tissue Plasminogen Activator
Rural Population
73 Citations (Scopus)

Minocycline and tissue-type plasminogen activator for stroke: assessment of interaction potential.

Machado, L. S., Sazonova, I. Y., Kozak, A., Wiley, D. C., El-Remessy, A. B., Ergul, A., Hess, D. C., Waller, J. L. & Fagan, S. C., Jan 1 2009, In : Stroke; a journal of cerebral circulation. 40, 9, p. 3028-3033 6 p.

Research output: Contribution to journalArticle

Minocycline
Tissue Plasminogen Activator
Plasminogen Activators
Stroke
Hemorrhage
93 Citations (Scopus)

Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke

Matsukawa, N., Yasuhara, T., Hara, K., Xu, L., Maki, M., Yu, G., Kaneko, Y., Ojika, K., Hess, D. C. & Borlongan, C. V., Oct 6 2009, In : BMC Neuroscience. 10, 1 p., 1471.

Research output: Contribution to journalArticle

Minocycline
Stroke
Cell Death
Neurological Models
Therapeutics
2008

Carotid endarterectomy - An evidence-based review: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology

Chaturvedi, S., Bruno, A., Feasby, T., Holloway, R., Benavente, O., Cohen, S. N., Cote, R., Hess, D. C., Saver, J., Spence, J. D., Stern, B. & Wilterdink, J., Feb 1 2008, In : CONTINUUM Lifelong Learning in Neurology. 14, 1, p. 197-204 8 p.

Research output: Contribution to journalArticle

Biomedical Technology Assessment
Carotid Endarterectomy
Pathologic Constriction
Endarterectomy
Stroke