David C Hess

EVP, Med Affairs & Dean, MCG

  • 10585 Citations
  • 57 h-Index
1989 …2019
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Research Output 1989 2019

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Review article
2018
1 Citation (Scopus)

Stem Cell Therapy in Cerebrovascular Disease

Nahhas, M. I. & Hess, D. C., Nov 1 2018, In : Current Treatment Options in Neurology. 20, 11, 49.

Research output: Contribution to journalReview article

Cerebrovascular Disorders
Cell- and Tissue-Based Therapy
Stem Cells
Clinical Trials
Stroke
2015
43 Citations (Scopus)

Remote ischaemic conditioning-a new paradigm of self-protection in the brain

Hess, D. C., Blauenfeldt, R. A., Andersen, G., Hougaard, K. D., Hoda, MD. N., Ding, Y. & Ji, X., Dec 1 2015, In : Nature Reviews Neurology. 11, 12, p. 698-710 13 p.

Research output: Contribution to journalReview article

Brain
Stroke
Clinical Trials
Intracranial Arteriosclerosis
Economic Inflation
2013
53 Citations (Scopus)

Remote limb preconditioning and postconditioning: Will it translate into a promising treatment for acute stroke?

Hess, D. C., Hoda, MD. N. & Bhatia, K., Apr 1 2013, In : Stroke. 44, 4, p. 1191-1197 7 p.

Research output: Contribution to journalReview article

Cerebrovascular Circulation
Neurological Models
Ischemic Preconditioning
Neurology
Reperfusion Injury
65 Citations (Scopus)

Teleneurology applications: Report of the telemedicine work group of the American Academy of Neurology

Wechsler, L. R., Tsao, J. W., Levine, S. R., Swain-Eng, R. J., Adams, R. J., Demaerschalk, B. M., Hess, D. C., Moro, E., Schwamm, L. H., Steffensen, S., Stern, B. J., Zuckerman, S. J., Bhattacharya, P., Davis, L. E., Yurkiewicz, I. R. & Alphonso, A. L., Feb 12 2013, In : Neurology. 80, 7, p. 670-676 7 p.

Research output: Contribution to journalReview article

Telemedicine
Neurology
Nervous System
Military Medicine
Primary Care Physicians
31 Citations (Scopus)

The history and future of telestroke

Hess, D. C. & Audebert, H. J., Jun 1 2013, In : Nature Reviews Neurology. 9, 6, p. 340-350 11 p.

Research output: Contribution to journalReview article

History
Stroke
Patient Care
Telecommunications
Patient Transfer
2012
35 Citations (Scopus)

Amniotic fluid stem cells: A promising therapeutic resource for cell-based regenerative therapy

Antonucci, I., Pantalone, A., Tetè, S., Salini, V., Borlongan, C. V., Hess, D. C. & Stuppia, L., May 1 2012, In : Current Pharmaceutical Design. 18, 13, p. 1846-1863 18 p.

Research output: Contribution to journalReview article

Amniotic Fluid
Stem Cells
Cell Transplantation
Cell- and Tissue-Based Therapy
Fetal Stem Cells
32 Citations (Scopus)

Clinical experience with three-factor prothrombin complex concentrate to reverse warfarin anticoagulation in intracranial hemorrhage

Switzer, J. A., Rocker, J., Mohorn, P., Waller, J. L., Hughes, D., Bruno, A., Nichols, F. T., Hess, D. C., Natrajan, K. & Fagan, S. C., Sep 1 2012, In : Stroke. 43, 9, p. 2500-2502 3 p.

Research output: Contribution to journalReview article

Intracranial Hemorrhages
Warfarin
Subdural Hematoma
Factor VII
Subarachnoid Hemorrhage
33 Citations (Scopus)

Permeating the blood brain barrier and Abrogating the inflammation in stroke: Implications for stroke therapy

Borlongan, C. V., Glover, L. E., Sanberg, P. R. & Hess, D. C., Oct 22 2012, In : Current Pharmaceutical Design. 18, 25, p. 3670-3676 7 p.

Research output: Contribution to journalReview article

Blood-Brain Barrier
Stroke
Inflammation
Cell- and Tissue-Based Therapy
NF-kappa B
2011
176 Citations (Scopus)

Stem Cell Therapy as an Emerging Paradigm for Stroke (STEPS) II

Savitz, S. I., Chopp, M., Deans, R., Carmichael, S. T., Phinney, D., Wechsler, L., Aronowski, J., Bednar, M., Boltze, J., Borlongan, C., Chase, T., Corbett, D., Cox, C. S., Cramer, S., Fischkoff, S., Frank, J., Greenberg, D., Hess, D., Hong, K., Koga, M. & 15 others, Jones, T., Keating, A., Kokaia, Z., Mays, R., Mora, K., Pittenger, M., Sanberg, P., Schallert, T., Sinden, J., Snyder, E., Steinberg, G., Victor, S., Willing, A., Yankee, E. & Yavagal, D., Mar 1 2011, In : Stroke. 42, 3, p. 825-829 5 p.

Research output: Contribution to journalReview article

Cell- and Tissue-Based Therapy
Stem Cells
Stroke
Industry
National Institutes of Health (U.S.)
128 Citations (Scopus)

Stroke treatment academic industry roundtable (STAIR) recommendations for maximizing the use of intravenous thrombolytics and expanding treatment options with intra-arterial and neuroprotective therapies

Albers, G. W., Goldstein, L. B., Hess, D. C., Wechsler, L. R., Furie, K. L., Gorelick, P. B., Hurn, P., Liebeskind, D. S., Nogueira, R. G. & Saver, J. L., Sep 1 2011, In : Stroke. 42, 9, p. 2645-2650 6 p.

Research output: Contribution to journalReview article

Industry
Stroke
Therapeutics
Reperfusion
Thrombolytic Therapy
20 Citations (Scopus)

Treatment of fever after stroke: Conflicting evidence

Wrotek, S. E., Kozak, W. E., Hess, D. C. & Fagan, S. C., Nov 1 2011, In : Pharmacotherapy. 31, 11, p. 1085-1091 7 p.

Research output: Contribution to journalReview article

Fever
Stroke
Body Temperature
Therapeutics
Patient Harm
2010
4 Citations (Scopus)
Drug Repositioning
Minocycline
Tissue Plasminogen Activator
Cerebral Hemorrhage
Stroke
15 Citations (Scopus)

Repurposing an old drug to improve the use and safety of tissue plasminogen activator for acute ischemic stroke: Minocycline

Hess, D. C. & Fagan, S. C., Jul 1 2010, In : Pharmacotherapy. 30, 7 PART 2, p. 55S-61S

Research output: Contribution to journalReview article

Drug Repositioning
Minocycline
Tissue Plasminogen Activator
Stroke
Cerebral Hemorrhage
105 Citations (Scopus)

Toward cell therapy using placenta-derived cells: Disease mechanisms, cell biology, preclinical studies, and regulatory aspects at the round table

Parolini, O., Alviano, F., Bergwerf, I., Boraschi, D., De Bari, C., De Waele, P., Dominici, M., Evangelista, M., Falk, W., Hennerbichler, S., Hess, D. C., Lanzoni, G., Liu, B., Marongiu, F., McGuckin, C., Mohr, S., Nolli, M. L., Ofir, R., Ponsaerts, P., Romagnoli, L. & 10 others, Solomon, A., Soncini, M., Strom, S., Surbek, D., Venkatachalam, S., Wolbank, S., Zeisberger, S., Zeitlin, A., Zisch, A. & Borlongan, C. V., Feb 1 2010, In : Stem Cells and Development. 19, 2, p. 143-154 12 p.

Research output: Contribution to journalReview article

Cell- and Tissue-Based Therapy
Placenta
Cell Biology
Stem Cells
Regenerative Medicine
2009
66 Citations (Scopus)

Amnion: A potent graft source for cell therapy in stroke

Seong, J. Y., Soncini, M., Kaneko, Y., Hess, D. C., Parolini, O. & Borlongan, C. V., Jun 16 2009, In : Cell Transplantation. 18, 2, p. 111-118 8 p.

Research output: Contribution to journalReview article

Amnion
Cell- and Tissue-Based Therapy
Stem cells
Grafts
Stroke
26 Citations (Scopus)

Systemic delivery of umbilical cord blood cells for stroke therapy: A review

Yu, G., Borlongan, C. V., Stahl, C. E., Hess, D. C., Ou, Y., Kaneko, Y., Yu, S. J., Yang, T., Fang, L. & Xie, X., Feb 20 2009, In : Restorative Neurology and Neuroscience. 27, 1, p. 41-54 14 p.

Research output: Contribution to journalReview article

Cell- and Tissue-Based Therapy
Fetal Blood
Blood Cells
Stroke
Transplantation
26 Citations (Scopus)

Telestroke 10 years later - 'telestroke 2.0'

Switzer, J. A., Levine, S. R. & Hess, D. C., Sep 1 2009, In : Cerebrovascular Diseases. 28, 4, p. 323-330 8 p.

Research output: Contribution to journalReview article

Stroke
Occupational Health Physicians
Teleradiology
Videoconferencing
Physicians
2008
82 Citations (Scopus)

Cell-based therapy in ischemic stroke

Hess, D. C. & Borlongan, C. V., Aug 1 2008, In : Expert Review of Neurotherapeutics. 8, 8, p. 1193-1201 9 p.

Research output: Contribution to journalReview article

Cell- and Tissue-Based Therapy
Stroke
Brain Injuries
Transplantation
Bone Marrow
15 Citations (Scopus)

Development of regional programs to speed treatment of stroke

Switzer, J. A. & Hess, D. C., Jan 1 2008, In : Current Neurology and Neuroscience Reports. 8, 1, p. 35-42 8 p.

Research output: Contribution to journalReview article

Program Development
Stroke
Thrombolytic Therapy
Therapeutics
Community Hospital
67 Citations (Scopus)

Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke

Hara, K., Yasuhara, T., Maki, M., Matsukawa, N., Masuda, T., Yu, S. J., Ali, M., Yu, G., Xu, L., Kim, S. U., Hess, D. C. & Borlongan, C. V., Jul 1 2008, In : Progress in Neurobiology. 85, 3, p. 318-334 17 p.

Research output: Contribution to journalReview article

Teratocarcinoma
Stem Cells
Transplantation
Stroke
Cell Line
72 Citations (Scopus)

Rural-urban differences in acute stroke management practices: A modifiable disparity

Leira, E. C., Hess, D. C., Torner, J. C. & Adams, H. P., Jul 1 2008, In : Archives of Neurology. 65, 7, p. 887-891 5 p.

Research output: Contribution to journalReview article

Practice Management
Stroke
Tertiary Healthcare
Emergency Medical Technicians
Patient Transfer
2007
1 Citation (Scopus)

Carotid stenosis: Endarterectomy or angioplasty and stenting?

Switzer, J. A. & Hess, D. C., Nov 1 2007, In : Current Treatment Options in Neurology. 9, 6, p. 451-462 12 p.

Research output: Contribution to journalReview article

Carotid Endarterectomy
Carotid Stenosis
Angioplasty
Pathologic Constriction
Endarterectomy
2006
17 Citations (Scopus)

Gene therapy, cell transplantation and stroke

Borlongan, C. V., Fournier, C., Stahl, C. E., Yu, G., Xu, L., Matsukawa, N., Newman, M., Yasuhara, T., Hara, K., Hess, D. C. & Sanberg, P. R., Feb 23 2006, In : Frontiers in Bioscience. 11, 1 P.889-1198, p. 1090-1100 11 p.

Research output: Contribution to journalReview article

Gene therapy
Cell Transplantation
Grafts
Genetic Therapy
Stroke
151 Citations (Scopus)

Pathophysiology and treatment of stroke in sickle-cell disease: present and future

Switzer, J. A., Hess, D. C., Nichols, F. T. & Adams, R. J., Jun 1 2006, In : Lancet Neurology. 5, 6, p. 501-512 12 p.

Research output: Contribution to journalReview article

Sickle Cell Anemia
Stroke
Therapeutics
Arteries
Erythrocyte Transfusion
26 Citations (Scopus)

Statins in stroke: Prevention, protection and recovery

Switzer, J. A. & Hess, D. C., Feb 1 2006, In : Expert Review of Neurotherapeutics. 6, 2, p. 195-202 8 p.

Research output: Contribution to journalReview article

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Stroke
Cholesterol
Coronary Artery Disease
Cause of Death
1 Citation (Scopus)

Statin therapy for coronary heart disease and its effect on stroke

Switzer, J. A. & Hess, D. C., Jul 1 2006, In : Current Atherosclerosis Reports. 8, 4, p. 337-342 6 p.

Research output: Contribution to journalReview article

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Coronary Disease
Stroke
Cholesterol
Therapeutics
2005

Multiple sclerosis: New help, new hope

Hess, D. C. & Hughes, M. D., Sep 1 2005, In : Consultant. 45, 10, p. 1144-1148 5 p.

Research output: Contribution to journalReview article

Multiple Sclerosis
Interferons
Disease Progression
Adrenal Cortex Hormones
Recurrence

Multiple sclerosis: When to suspect - Keys to diagnosis

Hess, D. C. & Hughes, M. D., Jul 1 2005, In : Consultant. 45, 8, p. 844-852 9 p.

Research output: Contribution to journalReview article

Multiple Sclerosis
Oligoclonal Bands
Diplopia
Paresis
Neurologic Manifestations
4 Citations (Scopus)

Statins and stroke prevention

Shaltoni, H. M., Yatsu, F. M. & Hess, D. C., Jan 1 2005, In : Current Atherosclerosis Reports. 7, 4, p. 313-318 6 p.

Research output: Contribution to journalReview article

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Stroke
Coronary Artery Disease
Cholesterol
Atherosclerosis
33 Citations (Scopus)

Tactics for vascular protection after acute ischemic stroke

Fagan, S. C., Hess, D. C., Machado, L. S., Hohnadel, E. J., Pollock, D. M. & Ergul, A., Mar 1 2005, In : Pharmacotherapy. 25, 3, p. 387-395 9 p.

Research output: Contribution to journalReview article

Blood Vessels
Stroke
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Thiazolidinediones
Minocycline
10 Citations (Scopus)

Transplantation of carotid body cells in the treatment of neurological disorders

Yu, G., Fournier, C., Hess, D. C. & Borlongan, C. V., Jan 1 2005, In : Neuroscience and Biobehavioral Reviews. 28, 8, p. 803-810 8 p.

Research output: Contribution to journalReview article

Carotid Body
Nervous System Diseases
Transplantation
Therapeutics
Stroke
2004
28 Citations (Scopus)

Do bone marrow cells generate neurons?

Hess, D. C., Hill, W. D., Carroll, J. E. & Borlongan, C. V., Apr 1 2004, In : Archives of Neurology. 61, 4, p. 483-485 3 p.

Research output: Contribution to journalReview article

Bone Marrow Cells
Neurons
Cardiac Myocytes
Muscle Cells
Hepatocytes
4 Citations (Scopus)

Healing a broken heart with stem cells

Stern, D. M., Hess, D. C. & Borlongan, C. V., Dec 1 2004, In : Cell Transplantation. 13, 7-8, p. 725-727 3 p.

Research output: Contribution to journalReview article

Stem cells
Stem Cells
Cell Transplantation
Cell- and Tissue-Based Therapy
Myocardial Infarction
202 Citations (Scopus)

Targets for vascular protection after acute ischemic stroke

Fagan, S. C., Hess, D. C., Hohnadel, E. J., Pollock, D. M. & Ergul, A., Sep 1 2004, In : Stroke. 35, 9, p. 2220-2225 6 p.

Research output: Contribution to journalReview article

Blood Vessels
Stroke
Pathologic Processes
Cerebral Arteries
Vascular System Injuries
2000
107 Citations (Scopus)

HMG-CoA reductase inhibitors (statins): A promising approach to stroke prevention

Hess, D. C., Demchuk, A. M., Brass, L. M. & Yatsu, F. M., Feb 22 2000, In : Neurology. 54, 4, p. 790-796 7 p.

Research output: Contribution to journalReview article

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Stroke
Coronary Artery Disease
Pravastatin
Simvastatin
39 Citations (Scopus)

Is nuclear factor-κB a good treatment target in brain ischemia/reperfusion injury?

Carroll, J. E., Hess, D. C., Howard, E. F. & Hill, W. D., Jun 26 2000, In : NeuroReport. 11, 9

Research output: Contribution to journalReview article

Reperfusion Injury
Brain Ischemia
Genes
Metalloproteases
Cyclooxygenase 2

New help, new hope

Hess, D. C., May 1 2000, In : Consultant. 40, 6, p. 1085-1094 10 p.

Research output: Contribution to journalReview article

Multiple Sclerosis
Relapsing-Remitting Multiple Sclerosis
Diplopia
Interferon-beta
Paresis
1993
22 Citations (Scopus)

Coronary artery disease, myocardial infarction, and brain embolism

Hess, D. C., D'Cruz, I. A., Adams, R. J. & Nichols, F. T., Jan 1 1993, In : Neurologic Clinics. 11, 2, p. 399-417 19 p.

Research output: Contribution to journalReview article

Intracranial Embolism
Coronary Artery Disease
Stroke
Myocardial Infarction
Anistreplase
1991
13 Citations (Scopus)

Sickle cell anemia and other hemoglobinopathies

Hess, D. C., Adams, R. J. & Nichols, F. T., Jan 1 1991, In : Seminars in Neurology. 11, 4, p. 314-328 15 p.

Research output: Contribution to journalReview article

Hemoglobinopathies
Sickle Cell Anemia