• 17393 Citations
  • 61 h-Index
1992 …2019
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Research Output 1992 2019

2003
103 Citations (Scopus)

Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed

Yi, X., Yin, X. M. & Dong, Z., May 9 2003, In : Journal of Biological Chemistry. 278, 19, p. 16992-16999 8 p.

Research output: Contribution to journalArticle

Oligomerization
Apoptosis
Membranes
Mitochondrial Membranes
Cytochromes c
18 Citations (Scopus)

Postmitochondrial regulation of apoptosis by bicarbonate

Dong, Z., Wang, J. & Zhong, Q., Aug 15 2003, In : Experimental Cell Research. 288, 2, p. 301-312 12 p.

Research output: Contribution to journalArticle

Bicarbonates
Apoptosis
Cytochromes c
Caspases
Chloride-Bicarbonate Antiporters
15 Citations (Scopus)

Role for recombinant γ-glutamyltransferase from Treponema denticola in glutathione metabolism

Chu, L., Xu, X., Dong, Z., Cappelli, D. & Ebersole, J. L., Jan 1 2003, In : Infection and Immunity. 71, 1, p. 335-342 8 p.

Research output: Contribution to journalArticle

Treponema denticola
Glutathione
Bacteria
Pyruvic Acid
Ammonia
2002
32 Citations (Scopus)

Gene promoter of apoptosis inhibitory protein IAP2: Identification of enhancer elements and activation by severe hypoxia

Dong, Z., Nishiyama, J., Yi, X., Venkatachalam, M. A., Denton, M., Gu, S., Li, S. & Qiang, M., Jun 1 2002, In : Biochemical Journal. 364, 2, p. 413-421 9 p.

Research output: Contribution to journalArticle

Inhibitor of Apoptosis Proteins
Genes
Chemical activation
Apoptosis
Rats
35 Citations (Scopus)

Role of glutathione metabolism of Treponema denticola in bacterial growth and virulence expression

Chu, L., Dong, Z., Xu, X., Cochran, D. L. & Ebersole, J. L., Mar 4 2002, In : Infection and Immunity. 70, 3, p. 1113-1120 8 p.

Research output: Contribution to journalArticle

Treponema denticola
Glutathione
Virulence
Periodontal Pocket
cysteinylglycine
2001
265 Citations (Scopus)

Bcl-2 Prevents Bax Oligomerization in the Mitochondrial Outer Membrane

Mikhailov, V., Mikhailova, M., Pulkrabek, D. J., Dong, Z., Venkatachalam, M. A. & Saikumar, P., Jan 25 2001, In : Journal of Biological Chemistry. 276, 21, p. 18361-18374 14 p.

Research output: Contribution to journalArticle

Oligomerization
Mitochondrial Membranes
Immunoprecipitation
Mitochondria
Adenosine Triphosphate
28 Citations (Scopus)

cDNA cloning and promoter analysis of rat caspase-9

Nishiyama, J., Yi, X., Venkatachalam, M. A. & Dong, Z., Nov 15 2001, In : Biochemical Journal. 360, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

Caspase 9
Cloning
Rats
Organism Cloning
Complementary DNA
31 Citations (Scopus)

Protection of ATP-depleted cells by impermeant strychnine derivatives: Implications for glycine cytoprotection

Dong, Z., Venkatachalam, M. A., Weinberg, J. M., Saikumar, P. & Patel, Y., Jan 1 2001, In : American Journal of Pathology. 158, 3, p. 1021-1028 8 p.

Research output: Contribution to journalArticle

Strychnine
Cytoprotection
Glycine
Adenosine Triphosphate
Fluorescein
129 Citations (Scopus)

Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia: HIF-1-independent mechanisms

Dong, Z., Venkatachalam, M. A., Wang, J., Patel, Y., Saikumar, P., Semenza, G. L., Force, T. & Nishiyama, J., Jun 1 2001, In : Journal of Biological Chemistry. 276, 22, p. 18702-18709 8 p.

Research output: Contribution to journalArticle

Inhibitor of Apoptosis Proteins
Up-Regulation
Genes
Apoptosis
Transcription
2000
68 Citations (Scopus)

Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury

Weinberg, J. M., Venkatachalam, M. A., Roeser, N. F., Saikumar, P., Dong, Z., Senter, R. A. & Nissim, I., Dec 7 2000, In : American Journal of Physiology - Renal Physiology. 279, 5 48-5

Research output: Contribution to journalArticle

Anaerobiosis
Succinic Acid
Citric Acid Cycle
Aspartic Acid
Wounds and Injuries
55 Citations (Scopus)

Heme oxygenase-1 in tissue pathology: The Yin and Yang

Dong, Z., Lavrovsky, Y., Venkatachalam, M. A. & Roy, A. K., Jan 1 2000, In : American Journal of Pathology. 156, 5, p. 1485-1488 4 p.

Research output: Contribution to journalComment/debate

Yin-Yang
Heme Oxygenase-1
Pathology
67 Citations (Scopus)

Serine protease inhibitors suppress cytochrome c-mediated caspase-9 activation and apoptosis during hypoxia-reoxygenation

Dong, Z., Saikumar, P., Patel, Y., Weinberg, J. M. & Venkatachalam, M. A., May 1 2000, In : Biochemical Journal. 347, 3, p. 669-677 9 p.

Research output: Contribution to journalArticle

Serine Proteinase Inhibitors
Caspase 9
Caspases
Cytochromes c
Chemical activation
1999
276 Citations (Scopus)

Apoptosis: Definition, mechanisms, and relevance to disease

Saikumar, P., Dong, Z., Mikhailov, V., Denton, M., Weinberg, J. M. & Venkatachalam, M. A., Nov 1999, In : American Journal of Medicine. 107, 5, p. 489-506 18 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-bcl-2
Lymphoproliferative Disorders
Graft Rejection
Virus Diseases
Caspases
1 Citation (Scopus)
Giant Cell Tumor of Bone
Recurrence
Curettage
1998
64 Citations (Scopus)

Development of porous defects in plasma membranes of adenosine triphosphate-depleted madin-darby canine kidney cells and its inhibition by glycine

Dong, Z., Patel, Y., Saikumar, P., Weinberg, J. M. & Venkatachalam, M. A., Jun 1 1998, In : Laboratory Investigation. 78, 6, p. 657-668 12 p.

Research output: Contribution to journalArticle

Madin Darby Canine Kidney Cells
Glycine
Dextrans
Adenosine Triphosphate
Cell Membrane
26 Citations (Scopus)

Intracellular Ca2+ thresholds that determine survival or death of energy-deprived cells

Dong, Z., Saikumar, P., Griess, G. A., Weinberg, J. M. & Venkatachalam, M. A., Jan 1 1998, In : American Journal of Pathology. 152, 1, p. 231-240 10 p.

Research output: Contribution to journalArticle

Adenosine Triphosphate
Glycine
Cell Death
Cell Survival
Cell Membrane
220 Citations (Scopus)

Mechanisms of cell death in hypoxia/reoxygenation injury

Saikumar, P., Dong, Z., Weinberg, J. M. & Venkatachalam, M. A., Jan 1 1998, In : Oncogene. 17, 25, p. 3341-3349 9 p.

Research output: Contribution to journalArticle

Cell Death
Wounds and Injuries
Apoptosis Regulatory Proteins
Caspase Inhibitors
Caspases
242 Citations (Scopus)

Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury

Saikumar, P., Dong, Z., Patel, Y., Hall, K., Hopfer, U., Weinberg, J. M. & Venkatachalam, M. A., Dec 31 1998, In : Oncogene. 17, 26, p. 3401-3415 15 p.

Research output: Contribution to journalArticle

Cytochromes c
Adenosine Triphosphate
Wounds and Injuries
Cell Death
Protein Transport
1997
2 Citations (Scopus)
Dantrolene
Phosphatidylinositols
Anura
Skeletal Muscle
Calcium
207 Citations (Scopus)

Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death: Involvement of serine but not cysteine proteases

Dong, Z., Saikumar, P., Weinberg, J. M. & Venkatachalam, M. A., Nov 1 1997, In : American Journal of Pathology. 151, 5, p. 1205-1213 9 p.

Research output: Contribution to journalArticle

DNA Cleavage
Cysteine Proteases
Serine
DNA Fragmentation
Cell Death
1996
40 Citations (Scopus)

Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels

Venkatachalam, M. A., Weinberg, J. M., Patel, Y., Saikumar, P. & Dong, Z., Jan 1 1996, In : Kidney International. 49, 2, p. 449-460 12 p.

Research output: Contribution to journalArticle

Chloride Channels
Cytoprotection
Glycine
Epithelial Cells
Kidney
2 Citations (Scopus)

Effect of caffeine on phosphoinositide metabolism in frog skeletal muscle

Dong, Z. & Zhu, P. H., Dec 1 1996, In : Chinese Journal of Physiological Sciences. 12, 2, p. 123-128 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Caffeine
Anura
Skeletal Muscle
Inositol
1 Citation (Scopus)

The accumulation of diacylglycerol and activation of protein kinase C induced by high K+ exposure in the frog skeletal muscle

Sun, J. H., Dong, Z. & Zhu, P. H., Dec 1 1996, In : Acta Biochimica et Biophysica Sinica. 28, 5, p. 574-575 2 p.

Research output: Contribution to journalArticle

Diglycerides
Anura
Protein Kinase C
Muscle
Skeletal Muscle
1995

3,4-Diaminopyridine induced hydrolysis of phosphoinositide in cultured neurons from embryo chick forebrain

Dong, Z. & Zhu, P. H., Jan 1 1995, In : Neuropharmacology. 34, 3, p. 297-302 6 p.

Research output: Contribution to journalArticle

Chick Embryo
Prosencephalon
Phosphatidylinositols
Hydrolysis
Neurons
1994
3 Citations (Scopus)

Effects of 3,4-diaminopyridine on myoplasmic calcium and phosphoinositide hydrolysis in frog sartorius muscle fibers

Xu, Z. M., Dong, Z. & Zhu, P. H., Jan 1 1994, In : Acta Pharmacologica Sinica. 15, 2, p. 139-141 3 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Anura
Muscle
Hydrolysis
Calcium
1992
4 Citations (Scopus)

Effect of high K+ exposure on phosphoinositide metabolism in frog skeletal muscle

Dong, Z., Chen, K. Y. & Zhu, P. H., Jan 31 1992, In : Biochemical and Biophysical Research Communications. 182, 2, p. 767-772 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Metabolism
Anura
Labeling
Muscle